Pseudo-Dipeptide Bearing α,α -Difluoromethyl Ketone Moiety as Electrophilic Warhead with Activity against CoronavirusesArticle Published on 2021-01-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] A549 activity Antiviral Bearing bind binding carried Cell cells comparable coronavirus cysteine proteases cytotoxicity difluoromethyl ketone distress docking evaluated fibroblast HCoV-229E human coronavirus human coronaviruses human embryonic lung in silico analysis indicated inhibit ketone M pro moiety Molecular dynamics simulation New nucleophilic performed protease SARS-CoV-2 SARS-CoV-2 Mpro similarity transfer viral cytopathic effect viral replication warhead [DOI] 10.3390/ijms22031398 PMC 바로가기 [Article Type] Article
Drug Repurposing: Dipeptidyl Peptidase IV (DPP4) Inhibitors as Potential Agents to Treat SARS-CoV-2 (2019-nCoV) InfectionArticle Published on 2021-01-082022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] 2019-nCoV acute respiratory distress addition agent Antiviral agents approach beta coronavirus caused Compliance computational modeling Computational study Coronavirus-2 cysteine protease cysteine proteases Dipeptidyl peptidase 4 dipeptidyl peptidase IV inhibitors distribution DPP4 drug Drug repurposing Efficacy inhibit inhibitor inhibitors of SARS-CoV-2 investigated M pro MERS-CoV MERS-CoV CLpro molecular docking outbreak pandemic Patient peptidase Potential profiles reduced SAR-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 Mpro dimer SARS-CoV-2 Mpro protomer serine proteases small molecule drug stability syndrome Therapies Treatment type-2 diabete type-2 diabetes Vaccine viable treatment [DOI] 10.3390/ph14010044 PMC 바로가기 [Article Type] Article
Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infectionTMPRSS2와 카텝신 B/L을 함께 표적으로 삼는 것은 SARS-CoV-2 감염에 대해 상승적일 수 있습니다Research Article Published on 2020-12-082022-08-13 Journal: PLoS Computational Biology [Category] Biochemistry, COVID-19, SARS, [키워드] ‘repurposing’ drugs achievement activate Activation blockade blocking blocking virus entry cathepsin Cathepsin B/L Cell cell lines cell population levels cell types cells clinical trials combination therapies combination therapy corresponding protease expression level COVID-19 COVID-19 pandemic cysteine cysteine protease cysteine proteases deployability dose-dependent manner drug drug combination drug combinations drugs targeting Effect Efficacy Efficiency effort entry of SARS-CoV-2 Evidence expression level facilitate help highlighting host protease host proteases host serine protease IMPROVE in vitro in vitro data in vivo independent independent entry pathway inhibitor inhibitors involved mathematical mathematical model minimal toxicities pathway Pathways potential treatment option predict predicted Prevent protease Proteases required SARS-CoV entry SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Serine Single Cell Spike protein synergistic Synergistic drug combination Synergistic drug combinations synergy target cell target cells targeting the cell tissue tropism TMPRSS2 toxicities Treatment triggered virus entry [DOI] 10.1371/journal.pcbi.1008461 PMC 바로가기 [Article Type] Research Article
Peptidyl Fluoromethyl Ketones and Their Applications in Medicinal ChemistryReview Published on 2020-09-032022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] application backbone can be used Cancer caspase cathepsin Chemistry Compound cysteine proteases disease Diseases enzymatic inhibitors Enzymes fluorinated peptides inhibit inhibitor insertion ketone modify pathogenic peptidyl fluoromethyl ketones physicochemical property probe protease Proteases proteolytic activity reactivity resulting SARS-CoV Mpro Serine serine proteases Treatment viral infections [DOI] 10.3390/molecules25174031 PMC 바로가기 [Article Type] Review
Deubiquitinating Enzymes in Coronaviruses and Possible Therapeutic Opportunities for COVID-19Review Published on 2020-05-152022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] activity acute respiratory syndrome affecting antiviral therapy clinical trial Consensus coronavirus coronavirus disease coronavirus epidemics Coronavirus infections COVID-19 COVID-19 therapy cysteine proteases drugs DUBs enzyme evaluated expressed function host cell host’s immune response immune response IMPROVE in vitro Infection inhibitor innate immune response intrinsic ISG15 majority Modification multifunctional opportunity outbreak pandemic Papain-like protease Pathogenesis pathway patient survival Pleiotropic effects PLP PLP inhibitors polypeptides Prevent protease Protein Proteins regulate Regulatory required responsible SARS SARS-CoV2 second Spread stability target proteins therapeutic strategy treat Treatment ubiquitin Viral pneumonia viral replication [DOI] 10.3390/ijms21103492 PMC 바로가기 [Article Type] Review
Exploring Leishmania infantum cathepsin as a new molecular marker for phylogenetic relationships and visceral leishmaniasis diagnosisResearch Article Published on 2019-10-282023-05-31 Journal: BMC Infectious Diseases [Category] Fulltext, [키워드] Leishmania (Leishmania) infantum Cathepsin L-like cysteine proteases Molecular diagnosis [DOI] 10.1186/s12879-019-4463-8 PMC 바로가기 [Article Type] Research Article
Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitorsOriginal Article Published on 2017-01-222022-10-30 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] Coronavirus, [키워드] Broussonetia papyrifera 3CL pro Analysis binding constant Broussonetia candidate Compound coronavirus cysteine proteases feature inhibitor inhibitory activity Interaction investigated kinetic Papain-like protease polyphenol protease Protease inhibitor responsible SARS [DOI] 10.1080/14756366.2016.1265519 PMC 바로가기 [Article Type] Original Article
Efficient expression systems for cysteine proteases of malaria parasites: too good to be true?article Published on 2013-04-302024-09-01 Journal: Bioengineered [Category] 말라리아, [키워드] auto-induction codon optimization cysteine proteases efficient expression systems Escherichia coli malaria parasites Pichia pastoris [Article Type] article