AID and APOBECs as Multifaceted Intrinsic Virus-Restricting Factors: Emerging Concepts in the Light of COVID-19AID와 APOBEC를 다면적 고유 바이러스 제한 요인으로: COVID-19에 비추어 볼 때 새로운 개념Immunology Published on 2021-07-012022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, [키워드] AID AID/APOBECs gene expression signature anatomical antibody production Antiviral antiviral response APOBEC APOBEC4 APOBECs Apolipoprotein B catalytic cell type cell types concept Coronaviruses COVID-19 cytidine Cytidine deaminase cytosine determinant Dissection DNA and RNA driving enzyme expression family members focus gene signature Germinal center highlight Host humoral immune response intrinsic LIGHT lymphoid lymphoid structures master regulator mechanism memory B cells mRNA plasma plethora polymorphism Reactions SARS-CoV-2 Structure subunit the patient uracil variety virus viruses [DOI] 10.3389/fimmu.2021.690416 PMC 바로가기 [Article Type] Immunology
High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2SARS-CoV-2에 대한 돼지 당-인간화 다클론항체의 높은 중화 효능Article Published on 2021-06-012022-09-12 Journal: European Journal of Immunology [Category] MERS, SARS, 진단, [키워드] accumulating acute respiratory syndrome allergy animal anti-SARS-CoV-2 Antibody Response Antibody-dependent enhancement assays binding Concentration convalescent plasma coronavirus coronavirus disease COVID-19 cytidine cytopathic Dilution domain Epitopes exacerbated Fc receptors fraction GGTA1 good manufacturing practices heterologous antibody Human human cell hyperimmune response IgG immunized Infection Inflammatory response inhibited Interaction mAbs monoclonal antibody multiple antigen neutralized Neutralizing neutralizing antibody pig polyclonal polyclonal antibodies polyclonal antibody purified Receptor binding domain SARS-CoV-2 serum sickness spike [DOI] 10.1002/eji.202049072 PMC 바로가기 [Article Type] Article
Profiling Ribonucleotide and Deoxyribonucleotide Pools Perturbed by Remdesivir in Human Bronchial Epithelial CellsPharmacology Published on 2021-05-042022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Activation acute respiratory syndrome addition Affect antiviral efficacy BEAS-2B BEAS-2B cell bronchial caused cell cycle arrest cellular click chemistry Concentration coronavirus coronavirus disease COVID-19 COVID-19 therapy cytidine Deoxyribonucleotide DNA DNA replication Effect Efficacy ENhance exacerbating hospitalized patient host cells Human implication increase in Infection inhibit inhibition of CTP synthase inhibition of RNA and DNA synthesis limit moderate monophosphate nucleotide nucleotides perturbation of nucleotide pools pool precursor Profiling purine RDV Remdesivir Replication resulting ribonucleotide ribonucleotides RNA SARS-CoV-2 survival rate Transcription Treatment Variation viral nucleic acids Viral RNA virus replication were measured [DOI] 10.3389/fphar.2021.647280 PMC 바로가기 [Article Type] Pharmacology
Coronavirus replication–transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit530 Published on 2021-02-092022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] activity acute respiratory syndrome antiviral drug arterivirus Cell culture cellular complex conserved Coronaviridae coronavirus Coronavirus replication Critical cytidine dependent on domain Evidence family Coronaviridae functional generate HCoV-229E homolog Hypothesis in vitro Interaction Ion M pro marker monophosphate mutant N terminus N-terminal Nidovirale nidovirus NiRAN Nsp12 nsp12 protein Nsp9 Nsps nucleotide nucleotidyltransferase observation polyprotein protease Protein proteolytic provide RdRps released Replication reported residue RNA polymerase RNA synthesis RNA viruses RNA-dependent RNA polymerase selective sequence shown Significance subunit suggested transfer transferase activity virus virus replication Vital [DOI] 10.1073/pnas.2022310118 PMC 바로가기 [Article Type] 530
Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic풍진 바이러스의 과돌연변이된 게놈과 COVID-19 전염병 동안 축적된 SARS-CoV-2 게놈의 돌연변이 스펙트럼 간의 유사성Research Article Published on 2020-10-022022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘, [키워드] accumulated accumulation Analysis APOBEC cytidine deaminase change characteristic COVID-19 pandemic cytidine Cytidine deaminase dataset Each enrichment event genomes genomic RNA human population hypermutated genome hypermutated genomes hypermutation individual isolate lead motif Mutation mutation mechanism mutation mechanisms mutational spectrum new SARS-CoV-2 pathological condition positive predicted preference Propagation reported RNA secondary structure RNA virus rubella rubella vaccine rubella vaccine virus rubella virus SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 mutation SARS-CoV-2 viruses SARS-CoV2 secondary structure sequenced similarity single base substitution single base substitutions single subject strand genomic RNA subclass substitutions suggested the SARS-CoV-2 virus virus isolate viruses [DOI] 10.1371/journal.pone.0237689 PMC 바로가기 [Article Type] Research Article
Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell cultureLetter Published on 2020-06-022022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] 2019-nCoV alkaloid Antiviral Antiviral compound Antiviral effect antiviral therapy approved broad-spectrum antiviral Cell culture China Combination Compound concentrations cytidine examined gemcitabine inhibit inhibited Novel coronavirus nucleosides outbreak SARS-CoV-2 SARS-COV-2 infection suppressed tested treat Vero-E6 cell viral disease viral infection Viral pneumonia viral replication virus [DOI] 10.1080/22221751.2020.1772676 PMC 바로가기 [Article Type] Letter
The divergence between SARS-CoV-2 and RaTG13 might be overestimated due to the extensive RNA modificationShort Communication Published on 2020-03-242022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] acute respiratory syndrome claimed contributed coronavirus cytidine Deamination Divergence explained hosts material methodology overestimate Phylogeny RaTG13 RNA modification SARS-CoV-2 SARS-related coronaviruses sequence Spread synonymous synonymous substitution [DOI] 10.2217/fvl-2020-0066 PMC 바로가기 [Article Type] Short Communication
Genome-wide identification of short 2′,3′-cyclic phosphate-containing RNAs and their regulation in aging짧은 2',3'-사이클릭 인산염 함유 RNA의 게놈 전체 식별 및 노화 조절Research Article Published on 2019-11-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulated adapter ligation adenosine advent aging Analysis biogenesis can not capture characterized cleavage cytidine cytoplasmic Degradation Determination effort event Evolution expressed expression expression level expression levels functional hidden identify ligation reaction mRNAs ncRNAs next-generation sequencing technology non-coding RNA Non-coding RNAs pathway phosphate physiological produced random reduction regulated Regulation remained ribonuclease RNA RNA molecule RNA molecules RNA-Seq RNAs rRNAs sequence standard RNA tissues Transcriptome tRNAs [DOI] 10.1371/journal.pgen.1008469 PMC 바로가기 [Article Type] Research Article
Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis PneumoniaHIV-1 질병 진행 및 기포자폐렴에서 APOBEC3F 유전자 변이의 역할Research Article Published on 2016-03-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95% CI acquisition Affect AIDS allele Americans antiviral activity APOBEC3 cytidine deaminase APOBEC3F APOBEC3G association cohorts collaboration cytidine cytidine deaminases Degradation degrade demonstrated disease Disease progression ENCODE epidemiological European Evidence Factor Frequency gene family Genetic genetic association Genetic variant genetic variants Genomics Haplotype hazard HIV HIV disease HIV-1 host susceptibility Human in vitro in vitro experiments in vivo intrinsic modify modulate Pathogenesis pathway performed Pneumonia progression Protein Proteins provide reduced relative resistance factors resolved role significantly lower SNP validation study variant Viral viral infectivity Viral load [DOI] 10.1371/journal.pgen.1005921 PMC 바로가기 [Article Type] Research Article