cytokine expression – Page 2 – Communicable Diseases Research

Will Auranofin Become a Golden New Treatment Against COVID-19?

Auranofin은 COVID-19에 대한 황금 신약이 될 것입니까?

Review

Published on 2021-09-222022-09-11
Journal: Frontiers in Immunology [Category] SARS, 변종, 신약개발,

SARS-CoV-2 Coronavirus Spike Protein-Induced Apoptosis, Inflammatory, and Oxidative Stress Responses in THP-1-Like-Macrophages: Potential Role of Angiotensin-Converting Enzyme Inhibitor (Perindopril)

Immunology

Published on 2021-09-202022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, SARS,

[키워드] ACE ACE2 activated Activation Analysis analyzed angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor Apoptosis binding Blood Cell cells changed circulation component conditioned media coronavirus CoV cytokine expression Effect Effects Endothelial cell entry of SARS-CoV-2 expression glycoprotein HUVEC cells increase in Inflammation Inflammatory marker inhibitor intracellular calcium intracellular cytokine involved Local Macrophage macrophage polarization macrophages MCP-1 MHC-II modulation monocyte/macrophages mononuclear cell oxidative stress pathway PBMC PBMCs Perindopril Peripheral blood phenotype Potential proinflammatory Proteins Proteomic analysis purified receptors reduced regulated response role ROS S protein SARS-CoV-2 sensitivity significantly increased spike Spike protein stimulated Stimulation systemically the S protein THP-1 TNFα treating Treatment upregulation Vascular viability was used
[DOI] 10.3389/fimmu.2021.728896 PMC 바로가기 [Article Type] Immunology

Combination of mesenchymal stem cells and nicorandil: an emerging therapeutic challenge against COVID-19 infection-induced multiple organ dysfunction

Commentary

Published on 2021-07-152022-10-29
Journal: Stem Cell Research & Therapy [Category] COVID-19, SARS,

Variable Induction of Pro-Inflammatory Cytokines by Commercial SARS CoV-2 Spike Protein Reagents: Potential Impacts of LPS on In Vitro Modeling and Pathogenic Mechanisms In Vivo

Article

Published on 2021-07-142022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19,

[키워드] ACE2 activity acute respiratory syndrome addition angiotensin-converting enzyme 2 antibody binding blockade blocked clinical outcomes commensal bacteria coronavirus correlated COVID-19 cytokine cytokine expression cytokine production endotoxin exhibited host cell immune responses Impact in vitro induce inducer induction Infection inflammatory cytokine production inhibited inhibitor Interaction Like LPS mechanism MERS Middle East modeling mononuclear cell mucosal tissue Neutralizing pathogenic pathway PBMC Peripheral blood Potential Proinflammatory cytokine promote reagent reagents reported respiratory SARS CoV-2 soluble ACE2 spike Spike protein variable
[DOI] 10.3390/ijms22147540 PMC 바로가기 [Article Type] Article

RIG-I-Like Receptor-Mediated Recognition of Viral Genomic RNA of Severe Acute Respiratory Syndrome Coronavirus-2 and Viral Escape From the Host Innate Immune Responses

중증 급성 호흡기 증후군 코로나바이러스-2의 바이러스 게놈 RNA의 RIG-I 유사 수용체 매개 인식 및 숙주 선천 면역 반응으로부터의 바이러스 탈출

Immunology

Published on 2021-06-252022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antiviral responses caused CCL5 coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 cytokine cytokine expression cytoplasmic destabilized epithelial cell epithelial cells escape expression fragment of genomic RNA Host host response human cells IFN-β immune responses in some induce infected cells inhibited Innate innate immune response innate immune responses Innate immunity Interaction involved IP-10 knockout MAVS MDA5 mechanism mRNA expression pandemic Particle Phosphorylation Protein Recognition recognize Region required respiratory response RIG-I RIG-I-like receptor RIG-I-like receptors RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell SARS-CoV-2-infected cells Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 TBK1 total RNA total RNAs transfection Trigger Type I IFN type I interferon Viral viral double-stranded RNA viral escape Viral RNA was reduced
[DOI] 10.3389/fimmu.2021.700926 PMC 바로가기 [Article Type] Immunology

Cytokine signatures of end organ injury in COVID-19

Article

Published on 2021-06-152022-10-04
Journal: Scientific Reports [Category] MERS, 바이오마커, 진단,

[키워드] activated AKI ARDS Autopsy chemokines cohort patient cohort study Control controls coronavirus disease 19 correlated cortical COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine expression demonstrated Diffuse alveolar damage disease driven by dysregulated Evidence examined glomerular histopathological examination hospital Hospitalized hospitalized patient hospitalized patients IL-13 immune pathways Immunity immunologic response Increasing Infectious diseases inflammatory cell infiltration Inflammatory cytokine kidney Kidney injury lung lymphocyte infiltration Macrophage Mortality negative controls New York City nine offer organ injury pathogenesis of COVID-19 predicted producing respiratory severity shown specimen stromal cell subsequent T cell T-cell Translational research Treatment strategies upregulation were measured with COVID-19
[DOI] 10.1038/s41598-021-91859-z PMC 바로가기 [Article Type] Article

Pathogenesis and Management of COVID-19

Review

Published on 2021-05-212022-10-30
Journal: Journal of Xenobiotics [Category] COVID-19,

Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection

강력한 SARS-CoV-2-특이 T 세포 면역은 1차 감염 후 6개월 동안 유지됩니다.

Article

Published on 2021-05-012022-09-12
Journal: Nature Immunology [Category] Fulltext, SARS, 진단,

COVID-19 in Immunosuppressed Children

Pediatrics

Published on 2021-04-292022-10-31
Journal: Frontiers in Pediatrics [Category] COVID-19,

[키워드] adaptive Autoimmune disease bat Cancer children clinical study competent coronavirus disease COVID-19 cytokine expression effective response element feature General population global pandemic hosts Hypothesis Immune-mediated Immunocompromised Immunosuppression Immunosuppressive medication Immunosuppressive treatment increased risk Infection Inflammasome innate immune system Innate immunity interferon kidney transplant liver transplant Manifestations mechanism mice multiorgan injury outcome over-inflammation pathogen clearance Patient pediatric phenotype populations pro-inflammatory signaling receiving reservoirs response rheumatologic diseases SARS-CoV-2 SARS-COV-2 infection SARS–CoV−2 severe COVID-19 Spread the disease the SARS-CoV-2 Tolerance Treatment type I viral clearance
[DOI] 10.3389/fped.2021.629240 PMC 바로가기 [Article Type] Pediatrics

Evidence of the pathogenic HERV-W envelope expression in T lymphocytes in association with the respiratory outcome of COVID-19 patients

COVID-19 환자의 호흡기 결과와 관련된 T 림프구의 병원성 HERV-W 외피 발현의 증거

Article

Published on 2021-04-012022-09-11
Journal: EBioMedicine [Category] Coronavirus, 바이오마커, 치료제,

[키워드] activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed Analysis association Biomarker Blood blood cell Blood cells blood sample Blood samples Clinical characteristics Clinical research Clinical signs coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 patient COVID-19 patients cytokine expression cytokine levels Cytokine storm Disease progression Effects effort Env evaluate evaluated evidence of Exhaustion expressed expression feature flow cytometry healthy donor healthy donors HERV HERV-W. human endogenous retroviruses HERVs highlighting Hospitalization human endogenous retroviruses identify immunopathological Infection infectious agent infectious agents Inflammation Inflammatory marker inflammatory markers leukocyte leukocytes lymphocyte management manuscript marker outcome pathogenic Patient Patient management Pneumonia predict progression of disease promote Protein Quantitative recent finding recent findings reflect Research respiratory Respiratory outcome retrovirus reverse transcriptase reverse transcriptase PCR SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity T lymphocyte T-cell differentiation T-cell exhaustion the disease Therapeutic approach therapeutic intervention
[DOI] 10.1016/j.ebiom.2021.103341 PMC 바로가기 [Article Type] Article