The role of A-to-I RNA editing in infections by RNA viruses: Possible implications for SARS-CoV-2 infectionRNA 바이러스 감염에서 A-to-I RNA 편집의 역할: SARS-CoV-2 감염에 대한 가능한 의미Review Published on 2021-05-012022-09-11 Journal: Clinical immunology (Orlando, Fla.) [Category] SARS, 변종, 치료법, [키워드] A-to-I RNA editing ADAR adenosine Affect APOBEC biological process cytosine cytosolic receptor cytosolic receptors Deamination double-stranded RNA double-stranded RNAs Effect enzyme events Evidence forms Future Host Host immune response implication Infection infections Innate innate immune response Innate immunity Inosine majority mapped Mutation mutations nucleotide patients with COVID-19 proliferation recent Recognition RNA RNA virus RNA viruses SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection shown single nucleotide Spike protein Substitution the spike protein uracil viral infections Viral protein viral replication [DOI] 10.1016/j.clim.2021.108699 PMC 바로가기 [Article Type] Review
Reducing SARS-CoV-2 pathological protein activity with small moleculesReview Paper Published on 2021-04-052022-10-29 Journal: Journal of Pharmaceutical Analysis [Category] COVID-19, [키워드] Abstract acting anti-SARS-CoV-2 APOBEC approach candidate coronavirus SARS-CoV-2 COVID-19 COVID-19 outbreak Curcumin cytosine Deamination disease Diseases drug drugs effective Epidemic Health Human Image indicated Infection inhibit molecular natural natural products nucleic acid Pathogens Protein Proteins reduce Replication SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RNA small molecule Strategy target the SARS-CoV-2 the SARS-CoV-2 genome therapeutic approaches Therapeutic nucleotides Treatment viral genome viral infection virus [DOI] 10.1016/j.jpha.2021.03.012 PMC 바로가기 [Article Type] Review Paper
Potential APOBEC-mediated RNA editing of the genomes of SARS-CoV-2 and other coronaviruses and its impact on their longer term evolutionArticle Published on 2021-04-012022-10-28 Journal: Virology [Category] COVID-19, MERS, SARS, [키워드] Amino acid antiviral activity APOBEC base changes in coronavirus coronavirus genomes Coronaviruses COVID-19 pandemic Cytidine deaminase cytosine determine directional DNA viruses Evidence Evolution Genome genomic hallmark herpesvirus homoplasy Innate immunity knowledge mammalian cell member Occurrence other coronavirus other coronaviruses Potential reported RNA RNA virus SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 sequence sequence sustained variant Viral proteins Virus evolution [DOI] 10.1016/j.virol.2020.12.018 PMC 바로가기 [Article Type] Article
Short sequence motif dynamics in the SARS-CoV-2 genome suggest a role for cytosine deamination in CpG reductionLetter to the Editor Published on 2021-03-252022-10-30 Journal: Journal of Molecular Cell Biology [Category] COVID-19, SARS, [키워드] CpG cytosine Deamination genome biology Genome evolution motif reduction sequence the SARS-CoV-2 genome Virus evolution virus‒host interaction [DOI] 10.1093/jmcb/mjab011 PMC 바로가기 [Article Type] Letter to the Editor
Identification and characterization of a silent mutation in RNA binding domain of N protein coding gene from SARS-CoV-2Comparative Study Published on 2021-01-062022-10-27 Journal: BMC Research Notes [Category] COVID-19, [키워드] acute respiratory syndrome addition Base excision repair binding domain changed China Chinese coding gene coding sequence COVID-19 cytosine DNA DNA sequence human immunity human-to-human transmission identification IMPROVE Iran leucine Missense mutation mutated Mutation N protein nucleocapsid objective Occurrence pathogenicity proline repair mechanism Result resulting risk RNA RNA binding domain RNA sequence SARS-CoV-2 silent single nucleotide TDG thymine Thymine DNA glycosylase (TDG) Transcription uracil Viral RNA Zinc [DOI] 10.1186/s13104-020-05439-x PMC 바로가기 [Article Type] Comparative Study
Identification and characterization of a silent mutation in RNA binding domain of N protein coding gene from SARS-CoV-2Comparative Study Published on 2021-01-062022-10-27 Journal: BMC Research Notes [Category] Coronavirus, COVID-19, [키워드] acute respiratory syndrome addition Base excision repair binding domain changed China Chinese coding gene coding sequence COVID-19 cytosine DNA DNA sequence human immunity human-to-human transmission identification IMPROVE Iran leucine Missense mutation mutated Mutation N protein nucleocapsid objective Occurrence pathogenicity proline repair mechanism Result resulting risk RNA RNA binding domain RNA sequence SARS-CoV-2 silent single nucleotide TDG thymine Thymine DNA glycosylase (TDG) Transcription uracil Viral RNA Zinc [DOI] 10.1186/s13104-020-05439-x PMC 바로가기 [Article Type] Comparative Study
Identification and characterization of a silent mutation in RNA binding domain of N protein coding gene from SARS-CoV-2SARS-CoV-2의 N 단백질 코딩 유전자의 RNA 결합 도메인에서 침묵 돌연변이의 식별 및 특성화Comparative Study Published on 2021-01-062022-09-10 Journal: BMC Research Notes [Category] 변종, 유전자 메커니즘, 치료기술, 치료법, [키워드] acute respiratory syndrome addition affinity Base excision repair binding domain changed China Chinese coding gene coding sequence COVID-19 cytosine DNA DNA sequence DNA sequences human body human immunity human-to-human transmission identification IMPROVE Iran leucine Missense mutation mutated Mutation N protein nucleocapsid nucleotide objective Occurrence pathogenicity proline repair mechanism respiratory Result resulting risk RNA RNA binding domain RNA sequence RNA sequences SARS-CoV-2 Severe acute respiratory syndrome silent single nucleotide TDG thymine Thymine DNA glycosylase (TDG) Transcription uracil Viral Viral RNA Zinc [DOI] 10.1186/s13104-020-05439-x PMC 바로가기 [Article Type] Comparative Study
Deaminase-Independent Mode of Antiretroviral Action in Human and Mouse APOBEC3 ProteinsReview Published on 2020-12-122022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Action antiretroviral Antiviral APOBEC3 APOBEC3G Apolipoprotein B catalytic characterized combating cytosine deaminase-independent antiretroviral function enzyme function HIV-1 Human immature innate immune system Innate immunity intrinsic involved knowledge mode molecular mechanism molecular mechanisms mouse mRNA pathway Protein Replication restriction factor retrotransposons single-stranded DNA suppress tumorigenesis uracil virus [DOI] 10.3390/microorganisms8121976 PMC 바로가기 [Article Type] Review
A path towards SARS-CoV-2 attenuation: metabolic pressure on CTP synthesis rules the virus evolutionResearch Article Published on 2020-10-302022-10-31 Journal: Genome Biology and Evolution [Category] COVID-19, MERS, SARS, [키워드] ABCE1 Antiviral ATP build coded consequence COVID-19 pandemic Critical cytidine triphosphate cytoophidia cytosine de novo enveloped RNA virus enzyme Evolution Genome glycosylation highlight Host Human genome innate antiviral immunity Intermediary metabolism Maxwell’s demon metabolite nsp1 nucleotide pathogenicity phosphoribosyltransferase precursor Protein queuine recombination event Replication required RNA genome SARS-CoV-2 sequence transcript transfer RNA translate unique uracil uridine triphosphate UTP viral envelope Viral protein Viral proteins virus virus genome [DOI] 10.1093/gbe/evaa229 PMC 바로가기 [Article Type] Research Article
Point mutation bias in SARS-CoV-2 variants results in increased ability to stimulate inflammatory responsesArticle Published on 2020-10-202022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome Affect cell line coronavirus Cytokines cytosine downstream enzyme Enzymes Factor gene mutation genomes guanine Host IL-6 immunology Impact induce Infection Inflammatory cytokine Inflammatory response mutated Mutation mutations Pathogenesis Point Point mutation prevalent Proofreading resulting RNA RNA viruses SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence severe pneumonia specificity ssRNA stimulate TNF-α upstream uracil variants of SARS-CoV-2 virus worldwide pandemic Wuhan [DOI] 10.1038/s41598-020-74843-x PMC 바로가기 [Article Type] Article