Are Host Defense Peptides and Their Derivatives Ready to be Part of the Treatment of the Next Coronavirus Pandemic?Review Published on 2021-09-162024-09-02 Journal: Archivum immunologiae et therapiae experimentalis [Category] 대상포진, [키워드] antimicrobial peptides Cathelicidin coronavirus defensin Host defense peptides Treatment [DOI] 10.1007/s00005-021-00630-9 PMC 바로가기 [Article Type] Review
A Fungal Defensin Targets the SARS−CoV−2 Spike Receptor−Binding DomainArticle Published on 2021-07-122022-10-30 Journal: Journal of Fungi [Category] COVID-19, [키워드] ACE2 antiviral agent antiviral drug approaches binding affinity Combination coronavirus coronavirus 2 defensin dermatophytic fungus domain drugs elicited enzyme exhibited fungal high affinity highlight host cell human ACE2 hydrogen bond network hydrophobic interacting residue Interaction interactions micasin Microsporum canis motif Point mutation predicted Prevent Protein RBD RBD binder RBM resource respiratory SARS−CoV−2 significantly spike target viral entry [DOI] 10.3390/jof7070553 PMC 바로가기 [Article Type] Article
Antimicrobial Peptides and Physical Activity: A Great Hope against COVID 19Review Published on 2021-06-302022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] accompanied adaptive immune responses addition adjuvants Alter AMP AMPs antimicrobial antimicrobial peptide antiviral properties antiviral property Cathelicidin chemokine Chemokine receptor chemokine receptors Complete coronavirus disease COVID 19 COVID-19 COVID-19 pathogenesis defensin derivative disrupting effective example healthy Hope Host immune increase in information Interaction Isolation mechanism microorganisms modulate physical activity potential therapy public health receptor receptors serum shown Support therapy TLRs Toll-like receptor Treatment Vaccine virus [DOI] 10.3390/microorganisms9071415 PMC 바로가기 [Article Type] Review
Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral EntryArticle Published on 2021-06-262022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] activities acute infection acute respiratory syndrome anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity antimicrobial peptides Antiviral antiviral activity binding blocked blocking Cell contribute COVID-19 disease Critical defensin Defensins Effect epithelial cells exhibited expressing Factor form hACE2 had no HNP1 Human Immunity Infection inhibited Innate innate immune intestinal investigated linear Lung epithelial cells MERS Middle East neutrophil outcomes Paneth cells peptide peptides Post-infection precursor protective effect provided Pseudotyped virus replication-competent SARS-CoV-2 reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike proteins SARS-CoV-2 variants severity spike receptor-binding domain syndrome the disease viral entry viral infection virion virus virus titer β-defensin [DOI] 10.3390/v13071246 PMC 바로가기 [Article Type] Article
Brilacidin Demonstrates Inhibition of SARS-CoV-2 in Cell CultureBrilacidin, 세포 배양에서 SARS-CoV-2 억제 입증Article Published on 2021-02-092022-09-10 Journal: Viruses [Category] MERS, 치료기술, 치료제, [키워드] acute respiratory syndrome coronavirus AMPs antimicrobial peptide antimicrobial peptides Antiviral antiviral activity biological properties biological property brilacidin Calu Calu-3 captures causative agent Cell culture cell line Clinical use coronavirus coronavirus 2 coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 disease Critical de novo death defensin demonstrated entry inhibition Evidence host defense human lung Increasing inhibit SARS-CoV-2 inhibition manuscript morbidity and mortality peptides peptidomimetic reduce referred to Remdesivir respiratory SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 small molecule strain synergistic therapeutic intervention therapeutic options These data treat Vero Viral viral entry virus [DOI] 10.3390/v13020271 PMC 바로가기 [Article Type] Article
Aminoglycosides can be a better choice over macrolides in COVID-19 regimen: Plausible mechanism for repurposing strategy아미노글리코사이드는 COVID-19 요법에서 마크로라이드보다 더 나은 선택이 될 수 있습니다: 용도 변경 전략을 위한 그럴듯한 메커니즘Article Published on 2020-11-012022-08-31 Journal: Medical Hypotheses [Category] SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] Aminoglycoside Andrographis antiviral activity Azithromycin clarithromycin COVID-19 COVID-19 pandemic defensin Defensins ENhance enhancer Immunity Innate Innate immunity lack mechanism microbes regimen reported repurposing Repurposing strategy. respiratory respiratory infection respiratory infections [DOI] 10.1016/j.mehy.2020.109984 PMC 바로가기 [Article Type] Article
Conjugation of Human β-Defensin 2 to Spike Protein Receptor-Binding Domain Induces Antigen-Specific Protective Immunity against Middle East Respiratory Syndrome Coronavirus Infection in Human Dipeptidyl Peptidase 4 Transgenic MiceArticle Published on 2020-11-012022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Activation acute respiratory symptoms Adaptive immune response addition adjuvant administration antibody Antigen can be used candidate vaccine cause conjugation defensin Dipeptidyl peptidase 4 domain dose effective Endoplasmic reticulum ENhance enhancing the immunogenicity HBD Human human β-defensin 2 immune response immunization intramuscular intranasal investigated lack lung Medical countermeasures MERS-CoV MERS-CoV infection mice Middle East mucosal IgA response peptidase provided pulmonary fibrosis required respiratory respiratory syndrome coronavirus S RBD Safe Signaling spike Spike protein Stress subunit suppressed vaccination Vaccine vaccine candidate viral infection [DOI] 10.3390/vaccines8040635 PMC 바로가기 [Article Type] Article
Innate Immunity and Influenza A Virus Pathogenesis: Lessons for COVID-19Cellular and Infection Microbiology Published on 2020-10-222022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] adverse effect adverse outcome airways disease antimicrobial peptide bacterial superinfection changes in comparison complex COVID 19 COVID-19 Cytokine storm defensin effort evaluate Evidence excessive inflammatory response Factor help Host IAV Infection inflammatory lung injury Inflammatory response Influenza influenza A virus inhibiting inhibitor Innate innate immune response Innate immunity knowledge lesson LL-37 Monocytes morbidity Mortality neutrophil pandemic positive Protein reactive Research SARS-CoV SARS-CoV virus Surfactant protein D treat viral replication virus [DOI] 10.3389/fcimb.2020.563850 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Antibacterial activity of a Tribolium castaneum defensin in an in vitro infection model of Streptococcus pneumoniaeStreptococcus pneumoniae의 인 비트로 감염 모델에서 Tribolium castaneum 방어 단백질의 항균 활성Research Paper Published on 2019-11-022024-07-31 Journal: Virulence [Category] 폐렴구균 감염증, [키워드] Antibiotic resistance antimicrobial peptides defensin Inflammation insect macrophages Streptococcus pneumoniae [DOI] 10.1080/21505594.2019.1685150 PMC 바로가기 [Article Type] Research Paper
Trichophyton tonsurans-induced kerion celsi with decreased defensin expression and paradoxically increased interleukin-17A productionArticle Published on 2019-09-302024-08-30 Journal: The Journal of Dermatology [Category] 백선증, [키워드] defensin dermatophytosis interleukin-17 Kerion Celsi Trichophyton tonsurans PMC 바로가기