A one-step platform for screening high-efficient and minimal off-target CRISPR/Cas13 crRNAs to eradicate SARS-CoV-2 virus for treatment of COVID-19 patientsCOVID-19 환자 치료를 위해 SARS-CoV-2 바이러스를 근절하기 위해 고효율 및 최소 표적 외 CRISPR/Cas13 crRNA를 스크리닝하기 위한 1단계 플랫폼Article Published on 2022-02-012022-09-11 Journal: Medical Hypotheses [Category] COVID19(2023년), SARS, 변종, 신약개발, 진단, 치료기술, 치료법, 치료제, [키워드] ACE2 ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Algorithm angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral applied caused cleavage clustered regularly interspaced short palindromic repeats coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19, Coronavirus disease 2019 CRISPR CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats CRISPR/Cas13 Degradation degrade develop diagnostics disease Effect effective enzyme foundation Gene Expression identify Nuclease Palindromic platform positive-sense Protein provide Replication respiratory Respiratory illness RNA RNA genome RNA viruses RNA-Seq SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 scRNA-seq scRNA-seq, Single-cell RNA-seq. severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single-cell RNA-seq Spread SRAS-CoV-2 target targeting Therapeutics treat Treatment Type viral genome viral mRNA viral mRNAs Viral RNA virus elimination [DOI] 10.1016/j.mehy.2021.110754 PMC 바로가기 [Article Type] Article
PROTAC targeted protein degraders: the past is prologue Reviews Published on 2022-01-182022-10-05 Journal: Nature Reviews Drug Discovery [Category] 신약개발, 치료제, [키워드] Cancer clinical development Degradation degrade disease-causing oncology Precision Protein provided reported review Small molecules target target protein therapeutic ubiquitin ligase [DOI] 10.1038/s41573-021-00371-6 [Article Type] Reviews
Neutrophil Extracellular Traps (NETs) and Covid-19: A new frontiers for therapeutic modalityArticle Published on 2022-01-062022-11-01 Journal: International immunopharmacology [Category] COVID-19, MERS, SARS, [키워드] Activation acute lung injury acute respiratory distress acute respiratory distress syndrome ALI, ARDS ARDS arginine caused cell membrane chromosomal DNA collateral tissue Complication complications Coronavirus disease 2019 COVID-19 Cytokine storm degrade drug Effect enzyme exaggerated immune response gasdermin D Histones hyperinflammation identify Immuno-thrombosis Infection Infectious disease infiltration inflammatory reaction Injury invading pathogens involved macrophage activation syndrome mitigate NET NETs Neutrophil elastase Neutrophil extracellular trap Neutrophil extracellular traps neutrophil recruitment nuclear protein organ pathogenesis of SARS-CoV-2 Patient patients Release Respiratory Coronavirus respiratory viral infection SARS-CoV-2 SARS-COV-2 infection severe SARS-CoV-2 sustained syndrome therapeutic therapy [DOI] 10.1016/j.intimp.2021.108516 PMC 바로가기 [Article Type] Article
Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19COVID-19에서 ARDS의 발병에 대한 안지오텐신 전환 효소 2(ACE2)Review Published on 2021-12-222022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 expression acute lung injuries acute respiratory distress acute respiratory distress syndrome addition angiotensin Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 Apelin ARDS aspiration bradykinin carboxypeptidase caused cell entry coronavirus COVID-19 COVID-19 pathogenesis COVID-19 patients Critical degrade downregulate Efficacy emergence enzymatic activity enzyme exhibit form higher affinity higher infectivity Infection Interaction Mutation neutralize Neutralizing antibodies Novel coronavirus pandemic Pathogenesis pathology pneumonias Protective Protein receptor Receptor-binding domain recombinant ACE2 Renin – Angiotensin – Aldosterone System respiratory distress resulting SARS Coronavirus SARS coronaviruses SARS-CoV-2 SARS-CoV-2 receptor Sepsis similarity spike Spike protein syndrome the epidemic the receptor-binding domain the SARS-CoV-2 the Spike Transmissibility treating COVID-19 Vaccine variant variants Viral [DOI] 10.3389/fimmu.2021.732690 PMC 바로가기 [Article Type] Review
Mechanism of Blood–Heart-Barrier Leakage: Implications for COVID-19 Induced Cardiovascular Injury혈액-심장 장벽 누출의 메커니즘: COVID-19로 인한 심혈관 손상에 대한 시사점Article Published on 2021-12-172022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] Activation acute respiratory syndrome alteration arising Blood cardiac function cardiac hypertrophy cardiovascular cause cause of death complications of COVID-19 congestive heart failure Corona virus COVID-19 COVID-19 viral myocarditis creatinine kinase isoforms death degrade Deleterious demonstrated determine dysfunction ECHO echocardiography endocardium endothelial Endothelium FITC gamut hallmark HCQ heart failure Hydroxychloroquine induced inhibit interstitium Laboratory leakage Manifestations matrix metalloproteinase matrix metalloproteinases mechanism Mfn2 mice Mitochondria mitochondrial mouse myocarditis novel corona virus Novel coronavirus phenotype Previous studies previous study respiratory Result resulting robust SARS-CoV-2 Severe acute respiratory syndrome shown Signaling subjects synchronous tissue tissue remodeling treated Treatment uncoupling variant viral myocarditis was measured were measured [DOI] 10.3390/ijms222413546 PMC 바로가기 [Article Type] Article
Specificity and sensitivity of an RNA targeting type III CRISPR complex coupled with a NucC endonuclease effectorAcademicSubjects/SCI00010 Published on 2021-12-162022-10-31 Journal: Nucleic Acids Research [Category] COVID-19, SARS, [키워드] activated activating Activation amplification binding complex CRISPR degrade dependent on detect DNA DNase domain ENCODE extrinsic generate guide RNA Immunity in vivo lack limit of detection locus Nuclease nucleic acid nucleotide position plate reader resulting RNA RNA secondary structure robust sensitivity sequence specificity stimulate subunit the SARS-CoV-2 virus Type type III variety Vibrio [DOI] 10.1093/nar/gkab1190 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Potential Use of CRISPR/Cas13 Machinery in Understanding Virus–Host InteractionMicrobiology Published on 2021-11-262022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acquisition approaches Cas13 Cas9 class component CRISPR-Cas Degradation degrade diagnostics DNA effector elements Features Genetic identify immune system Interaction modulate Nuclease nucleases nucleic acid offer Palindromic phage plasmids Potential Prokaryote Protein Proteins recognizing Repeat Research RNA RNA interference RNA-labeling sequence spacer subsequent understanding variant Viral RNA Virological virus diagnosis virus interference virus resistance [DOI] 10.3389/fmicb.2021.743580 PMC 바로가기 [Article Type] Microbiology
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injuryACE2-유사 카르복시펩티다제 B38-CAP는 SARS-CoV-2로 유발된 폐 손상으로부터 보호합니다Article Published on 2021-11-232022-09-12 Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 expression acting acute lung injury alleviate angiotensin Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal models carboxypeptidase cardiovascular disease cell entry COVID-19 patients decoy degrade downregulate downregulated edema Elevation endogenous enzymatic activity enzyme Evidence human ACE2 IMPROVE in vivo Infection inhibit inhibit SARS-CoV-2 lung lung edema Lung injury Lung pathology Lungs not neutralize Pathologies pathology peptides PROTECT Protective Protein receptor recombinant Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected hamster SARS-CoV-2-infected hamsters significantly soluble ACE2 spike Symptom therapeutic strategy transgenic mice Treatment virus [DOI] 10.1038/s41467-021-27097-8 PMC 바로가기 [Article Type] Article
SARS‐CoV‐2 targeting by RNAi and host complement inhibition: A two‐pronged subterfuge for COVID‐19 treatmentRNAi에 의한 SARS-CoV-2 표적화 및 숙주 보체 억제: COVID-19 치료를 위한 두 갈래의 속임수Review Published on 2021-10-132022-09-10 Journal: Immunity, Inflammation and Disease [Category] 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach C3a clinical manifestation clinical manifestations complement Complement inhibitor component conjunction coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 patients curtail cytokine Cytokine storm degrade detrimental Disease progression disease progression and severity downstream effective Evidence exacerbate gene regulation processes globe Host immune responses infections information inhibitor knowledge lack less Local mitigate molecules ORF Perspective preventive measure preventive measures progression Proinflammatory cytokine protective immunity Replication required respiratory Result RNA interference RNAi robust SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus severity Spread suppress symptomatic and asymptomatic systemic immune response systemic immune responses the cytokine storm transcript transmissible variant Treatment vaccinate Vaccine variants Viral viral spread viral/retroviral virus [DOI] 10.1002/iid3.549 PMC 바로가기 [Article Type] Review
Graphene‐Based Technologies for Tackling COVID‐19 and Future PandemicsPerspective Published on 2021-09-162022-10-28 Journal: Advanced Functional Materials [Category] COVID-19, [키워드] 2D materials biosensors can be used continuous monitoring COVID‐19 COVID‐19 symptoms COVID‐19 degrade develop Efficiency electrical ENhance filtration functional Future Graphene highlight infected patients Infectious disease infectious viruses Isolation mechanism pandemic Pandemics Personal protective equipment platform Spread technology Viral diseases virus viruses wearables [DOI] 10.1002/adfm.202107407 PMC 바로가기 [Article Type] Perspective