D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation
Accelerated Communication
[키워드] 3DVA, three-dimensional variability analysis
ACE2, angiotensin converting enzyme 2
Alter
approach
binding
Characteristics
cold-induced unfolding
conformational
conjugate
COVID-19 pandemic
Cryo-electron microscopy
CTF, contrast transfer function
D614G
D614G mutation
demonstrated
denaturation
differential scanning fluorimetry
dominant
DSC, differential scanning calorimetry
DSF, differential scanning fluorimetry
ENhance
exceptional
exhibited
host receptor
mechanism
Microscopy
molecular basis
Multiple
Mutation
NSEM, negative staining electron microscopy analysis
physiological
protein stability
RBD, receptor-binding domain
RBDs
RBM, receptor-binding motif
Receptor-binding domain
SARS-CoV-2
SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2
significantly
Spike protein
stability
staining
the SARS-CoV-2
the spike protein
thermal stability
Thermodynamics
Vaccine development
variant
viral fitness
Viral protein
virus
WT, wild type
[DOI] 10.1016/j.jbc.2021.101238 PMC 바로가기 [Article Type] Accelerated Communication
[DOI] 10.1016/j.jbc.2021.101238 PMC 바로가기 [Article Type] Accelerated Communication