Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management: Could These Be Effective Antivirals for COVID-19 Treatment?COVID-19 관리를 위한 Artemisia 추출물 및 Artemisinin 기반 항말라리아제: 이것이 COVID-19 치료에 효과적인 항바이러스제일 수 있습니까?Review Published on 2022-06-142022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] active against acts acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Anti-inflammatory effects Antiviral Artemisia Artemisinin artemisinins combination therapies coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 demonstrated derivative derivatives Drug repurposing drug repurposing. Effect Effectiveness Evidence exhibit Extract IL-6 Infection Inflammation inhibiting interleukin-6 Invasion lung damage malaria other diseases oxidative stress pandemic positive reducing Replication SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 shown Symptoms the SARS-CoV-2 treat Treatment [DOI] 10.3390/molecules27123828 PMC 바로가기 [Article Type] Review
Synthesis and Antiviral Properties against SARS-CoV-2 of Epoxybenzooxocino[4,3- b]Pyridine DerivativesEpoxybenzooxocino[4,3-b]Pyridine 유도체의 SARS-CoV-2에 대한 합성 및 항바이러스 특성Article Published on 2022-06-092022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral activity approved drug cell cultures clinically comparable compounds COVID-19 pandemic demonstrated derivative derivatives described drugs epoxybenzooxocinopyridine derivatives. half-maximal effective concentration inhibit property Replication SARS-CoV-2 SARS-CoV-2 virus Seven suppress synthesis tested the SARS-CoV-2 virus therapeutic [DOI] 10.3390/molecules27123701 PMC 바로가기 [Article Type] Article
Synthesis of Dihydrobenzofuro[3,2-b]chromenes as Potential 3CLpro Inhibitors of SARS-CoV-2: A Molecular Docking and Molecular Dynamics StudySARS-CoV-2의 잠재적인 3CLpro 억제제로서의 디하이드로벤조푸로[3,2-b]크로멘 합성: 분자 도킹 및 분자 역학 연구Article Published on 2022-04-202022-09-11 Journal: ChemMedChem [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro 3CLpro inhibitors acute respiratory syndrome acute respiratory syndrome coronavirus approach Bioactivity bioinformatics caused chymotrypsin Clustering analysis Compound Control coronavirus Coronavirus replication COVID-19 cysteine cysteine protease derivatives drug target Dynamics enzyme flavonoid flavonoids fused fused flavonoids Health in-silico Infection inhibitor inhibitor N3 inhibitors life cycle MERS-CoV methodology Middle East Middle East respiratory syndrome Coronavirus molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulation. molecular interaction pandemic Potential Protein raised respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus synthesis therapeutic Toxicity unavailability viral life cycle [DOI] 10.1002/cmdc.202100782 PMC 바로가기 [Article Type] Article
Clofazimine derivatives as potent broad-spectrum antiviral agents with dual-target mechanism이중 표적 기전을 가진 강력한 광범위 항바이러스제로서의 클로파지민 유도체Article Published on 2022-04-152022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral activity antiviral agent Antiviral effect binding broad-spectrum Candidates Clofazimine Clofazimine analogues comparable Compound derivative derivatives evaluated inhibit inhibited lead mechanism membrane fusion nsp13 Protein provided rabies Rabies virus Raby S protein SARS-CoV-2 Structure–activity relationship. [DOI] 10.1016/j.ejmech.2022.114209 PMC 바로가기 [Article Type] Article
Pegcetacoplan for paroxysmal nocturnal hemoglobinuriaResearch article Published on 2022-03-292022-10-05 Journal: Blood [Category] 비임상, [키워드] Anemia approach clinical study complement Complement inhibitor derivatives effective Hemolysis inhibit inhibitor paroxysmal nocturnal hemoglobinuria Patient resulting Sequencing symptomatic Treatment [DOI] 10.1182/blood.2021014868 [Article Type] Research article
In Silico Analysis and Synthesis of Nafamostat Derivatives and Evaluation of Their Anti-SARS-CoV-2 ActivityBrief Report Published on 2022-02-142022-10-28 Journal: Viruses [Category] COVID-19, COVID19(2023년), SARS, [키워드] activity acute respiratory syndrome Analysis anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity anti-SARS-CoV-2 agent Antiviral effect binding binding affinity camostat contribute coronavirus covalent bond COVID-19 CPE Cytopathic effect derivative derivatives element expected greater inhibition interact investigated molecular nafamostat predicted reported SARS-CoV-2 shown significantly synthesis TMPRSS2 TMPRSS2 inhibitor transmembrane serine protease unique weakened [DOI] 10.3390/v14020389 PMC 바로가기 [Article Type] Brief Report
Synthesis of chiral sulfinate esters by asymmetric condensation Research Published on 2022-02-142022-10-05 Journal: Nature [Category] 치료제, [키워드] alcohol approach asymmetric Candidates derivatives drug drugs expand functional group groups initial pharmacokinetic pharmacophores physicochemical resulting Structure synthesis unique viability [DOI] 10.1038/s41586-022-04524-4 [Article Type] Research
Isolation and In Silico Anti-SARS-CoV-2 Papain-Like Protease Potentialities of Two Rare 2-Phenoxychromone Derivatives from Artemisia spp.Article Published on 2022-02-112022-10-30 Journal: Molecules [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Artemisia commutate 2-phenoxychromones addition ADMET being binding binding energy carried co-crystallized conducted COVID-19 COVID-19 Papain-Like Protease derivative derivatives drugs eight Enzymes exhibiting in silico indicated investigated Ligand MD simulations molecular molecular docking Molecular docking study molecular fingerprints PDB PLP potentiality SARS-CoV-2 Seven similarity Simulation study thermodynamic Toxicity [DOI] 10.3390/molecules27041216 PMC 바로가기 [Article Type] Article
Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global DemandPlant Science Published on 2022-02-072022-10-31 Journal: Frontiers in Plant Science [Category] COVID-19, [키워드] Artemisia annua Activation anti-SARS-CoV-2 ART Artemisinin boost cancers clinical study combating compounds COVID-19 COVID-19 pandemic Demand derivatives different disease Effect effective human ACE2 human cells IKK Increased Inflammation Interaction interfere Like malaria NF-κB signaling option pathway positive receptors SARS-CoV-2 SARS-COV-2 infection sesquiterpene lactone Symptom these compound transcriptional activity Treatment viral endocytosis viral infections viral spike protein [DOI] 10.3389/fpls.2022.780257 PMC 바로가기 [Article Type] Plant Science
Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CL pro inhibitors for treating COVID-19COVID-19 치료를 위한 SARS-CoV-2 3CL pro 억제제로서의 9,10-디히드로페난트렌 유도체 발견Article Published on 2022-01-152022-09-11 Journal: European journal of medicinal chemistry [Category] 신약개발, 치료제, [키워드] 3CL pro 9,10-Dihydrophenanthrenes acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition binding mode binding modes caused chymotrypsin Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cysteine cysteine protease derivative derivatives docking drug target enzyme Epidemic gastrointestinal tract human liver Human plasma in viral inhibit SARS-CoV-2 inhibition activity inhibitor investigated Protein Replication SARS-CoV-2 SARS-CoV-2 3CL(pro) severe acute respiratory syndrome Coronavirus Spread stability Structure-activity relationships. target tested the SARS-CoV-2 treating COVID-19 viral replication [DOI] 10.1016/j.ejmech.2021.114030 PMC 바로가기 [Article Type] Article