SARS-CoV-2 infection of human-induced pluripotent stem cells-derived lung lineage cells evokes inflammatory and chemosensory responses by targeting mitochondrial pathways인간 유도 만능 줄기 세포 유래 폐 계통 세포의 SARS-CoV-2 감염은 미토콘드리아 경로를 표적으로 하여 염증 및 화학 감각 반응을 유발합니다Article Published on 2022-07-012022-09-12 Journal: Journal of cellular physiology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated acute respiratory syndrome addition Affect airway alveolar alveolar cells Antiviral Apoptosis caused Cell cells chemosensory chemosensory response complexes Consequences coronavirus COVID-19 COVID-19 disease COVID-19 patients Defense developmental distal dysregulation epithelial HMOX1 IL-13 IL-6 immune responses in viral in vitro Increased induced pluripotent stem cells INF-γ infected cell Inflammatory Inflammatory response Lineage lung lung epithelial Lung epithelial cells Lung injury lung tissue maturation mechanism metabolic processe mitochondrial mitochondrial damage. pathway precursor Proinflammatory cytokine proximal replicated response resulting robust ROS ROS production SARS-CoV-2 SARS-COV-2 infection spatiotemporal therapeutic drug TNF-α transcriptomics Transport upregulated upregulation [DOI] 10.1002/jcp.30755 PMC 바로가기 [Article Type] Article
Insertion-and-Deletion Mutations between the Genomes of SARS-CoV, SARS-CoV-2, and Bat Coronavirus RaTG13SARS-CoV, SARS-CoV-2 및 박쥐 코로나바이러스 RaTG13의 게놈 간의 삽입 및 삭제 돌연변이Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 base bases bat bat coronavirus RaTG13 Complete coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) developmental distribution FIVE Frame gene sequence Genome genome sequence Genome sequences genomes Inconclusive INDEL indels insertion insertion-and-deletion mutation mechanism MOST Mutation mutation rate mutations Noncoding region nonstructural protein 3 Open reading frame ORF ORF8 ORF8 gene ORF8 genes Point mutation point mutations protein 3 RaTG13 replaced REPLACED BY replacement S1 domain SARS-CoV SARS-CoV-2 SARS-CoV-2 genome sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus (SARS-CoV) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike protein the SARS-CoV-2 genome the spike protein viral genome virus [DOI] 10.1128/spectrum.00716-22 PMC 바로가기 [Article Type] Article
Onasemnogene abeparvovec for presymptomatic infants with two copies of SMN2 at risk for spinal muscular atrophy type 1: the Phase III SPR1NT trial Research Published on 2022-06-172022-10-05 Journal: Nature Medicine [Category] 변종, 유전자 메커니즘, 임상, [키워드] biallelic children Clinical research Cohort develop developmental effective Efficacy and safety enrolled expected Final highlighting Infant investigator multicenter muscular Mutation Neuromuscular Newborn phase presymptomatic Respiratory Support risk Serious Adverse Event single-arm study SMN1 SMN2 survived treated Treatment Trial urgency Ventilation WHO [DOI] 10.1038/s41591-022-01866-4 [Article Type] Research
Onasemnogene abeparvovec for presymptomatic infants with three copies of SMN2 at risk for spinal muscular atrophy: the Phase III SPR1NT trial Research Published on 2022-06-172022-10-05 Journal: Nature Medicine [Category] 변종, 유전자 메커니즘, 임상, 진단, [키워드] biallelic children Deletion develop developmental effective Efficacy and safety Infant Intervention investigated investigator MOST multicenter muscular Mutation phase presymptomatic required Respiratory Support risk Serious Adverse Event single-arm trial SMN1 SMN2 Support survived symptom onset treated Trial urgency Ventilation WHO [DOI] 10.1038/s41591-022-01867-3 [Article Type] Research
Variant to function mapping at single-cell resolution through network propagation Research Published on 2022-06-062022-10-05 Journal: Nature biotechnology [Category] 유전자 메커니즘, [키워드] Algorithm Analysis approach association Blood causal variant cell types cellular Combination COVID-19 developmental epigenomic Genetic variation help Hematopoiesis human genetic variation identify Inference leukemia lymphocyte mechanism monocyte network propagation overcome provide risk single-cell single-cell genomic Stage subset trajectory [DOI] 10.1038/s41587-022-01341-y [Article Type] Research
Health literacy and fear among Iranian medical students due to COVID-19: An observational studyObservational Study Published on 2022-05-012022-10-05 Journal: Brain and Behavior [Category] COVID19(2023년), SARS, 임상, [키워드] age analyzed assist conducted coronavirus disease correlation COVID-19 cross-sectional developmental education emotional fear female Gender Health health literacy IMPROVE Iran male males medical student negative correlation not significant pandemic participant positive reduce Research response significantly SPSS software Sustainable Development Goals Treatment [DOI] 10.1002/brb3.2586 PMC 바로가기 [Article Type] Observational Study
COVID-19 and the promise of small molecule therapeutics: Are there lessons to be learnt?COVID-19와 소분자 치료제의 약속: 배워야 할 교훈이 있습니까?Review Published on 2022-05-012022-09-11 Journal: Pharmacological research [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant therapy Antiviral antiviral agent Antiviral agents antivirals Baricitinib Baricitinib (PubChem CID: 44205240) Chloroquine Chloroquine (PubChem CID: 2719) coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical developmental Dexamethasone Dexamethasone (PubChem CID: 5743) drug Drug discovery effective Endemic Healthcare professional healthcare professionals Hydroxychloroquine Hydroxychloroquine (PubChem CID: 3652) Inclusion Ivermectin Ivermectin (PubChem CID: 6321424) limitation Lopinavir Lopinavir (PubChem CID: 92727) molnupiravir Molnupiravir (Pubchem CID: 145996610) Nirmatrelvir Nirmatrelvir (PubChem CID: 155903259) pandemic provided PubChem Remdesivir Remdesivir (PubChem CID: 121304016) researcher Retrospective analysis Ritonavir Ritonavir (PubChem CID: 392622) SARS-CoV-2 severe acute respiratory syndrome Coronavirus small molecule Small molecule therapeutics. standstill tested the disease therapy Treatment treatment of COVID-19 while with COVID-19 [DOI] 10.1016/j.phrs.2022.106201 PMC 바로가기 [Article Type] Review
Undetectable viral RNA in follicular fluid, cumulus cells, and endometrial tissue samples in SARS-CoV-2-positive womenSARS-CoV-2 양성 여성의 난포액, 난운 세포 및 자궁내막 조직 샘플에서 검출할 수 없는 바이러스 RNAObservational Study Published on 2022-04-012022-09-11 Journal: Fertility and sterility [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] 48 hours Adequate affecting analyzed ART assisted reproductive technology can not caution cells clinical Clinical outcome clinical outcomes conception counseling cumulus cells cycle Cycle threshold values developmental Embryo embryo transfer endometrium English fertilization follicular Follicular fluid hospital human embryo. in vitro In vitro fertilization infected with SARS-CoV-2 Inflammatory injection Intracytoplasmic sperm injection lesion observational study Oocyte outcome para parameter parameters Patient positive Primary outcome Prospective prospectivo registration number reproductive Reproductive technology Research Retrieval risk RT-PCR Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 viral RNA secondary outcome single-center small sample size Spanish Tertiary threshold value tissue sample TRA transfer Trial registration undetectable Viral RNA women [DOI] 10.1016/j.fertnstert.2021.12.032 PMC 바로가기 [Article Type] Observational Study
A double-blind randomized controlled trial investigating a time-lapse algorithm for selecting Day 5 blastocysts for transferRandomized Controlled Trial Published on 2022-04-012022-10-05 Journal: Human reproduction (Oxford, England) [Category] 임상, [키워드] 1:1 95% CI addition Affect Algorithm Analysis applied blastocyst blind Can changed Characteristics clinics control group Coronavirus disease-19 correlation Culture culture media Date Day developmental double-blind Embryo embryo selection employment evaluated event Evidence Final FIVE good quality Government highest implication IMPROVE Intervention intervention group investigated IVF limit mean difference Morphological morphology Most patient multicenter Patient performed Pregnancy Pregnancy rate primary clinical outcome Primary outcome Prognosis proportion randomization Randomized Randomized controlled trial randomized patient recruitment Sample size selected significantly single embryo transfer statistically significant difference study group study groups study period subgroup analysis Support supported Swedish the patient time-lapse. transfer transferred Treatment Trial two groups viability was performed were blinded [DOI] 10.1093/humrep/deac020 PMC 바로가기 [Article Type] Randomized Controlled Trial
Persistence of Naturally Acquired and Functional SARS-CoV-2 Antibodies in Blood Donors One Year after Infection감염 1년 후 헌혈자의 자연적으로 획득되고 기능적인 SARS-CoV-2 항체의 지속성Article Published on 2022-03-182022-09-11 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] AB0 blood groups Acquired Affect age anti-N antibodies anti-N antibody anti-S antibody antibodies antibody antibody levels antibody production Awareness Blood blood donation blood donor Blood donors Blood Group Cohort Course COVID-19 COVID-19-related symptom declining developmental disease course Europe evaluated FIVE functional groups healthy immune response in vitro individual Infection investigated long-COVID Naturally nine participant produced SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection Seroprevalence Sex significantly lower spike-protein the disease the viral nucleocapsid vaccination Vaccination Status Viral Year [DOI] 10.3390/v14030637 PMC 바로가기 [Article Type] Article