disease pathogenesis – Page 2 – Communicable Diseases Research

A Game of Infection – Song of Respiratory Viruses and Interferons

감염의 게임 - 호흡기 바이러스와 인터페론의 노래

Review

Published on 2022-06-292022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 치료제,

Cell deaths: Involvement in the pathogenesis and intervention therapy of COVID-19

세포 사멸: COVID-19의 병인 및 중재 요법에 대한 참여

Review

Published on 2022-06-132022-09-11
Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 임상, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Apoptosis autophagy caused Cell cell death coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease disease pathogenesis Effective strategies effective strategy Ferroptosis homeostasis Host Increasing indicated Infection Interaction Intervention involved Involvement knowledge lack mechanism necroptosis NETosis Occurrence pandemic Pathogenesis pathogenicity pathology present Prevent progression pyroptosis SARS-CoV-2 severe acute respiratory syndrome Coronavirus Therapies therapy treat virus infection
[DOI] 10.1038/s41392-022-01043-6 PMC 바로가기 [Article Type] Review

Machine learning of COVID-19 clinical data identifies population structures with therapeutic potential

Research article

Published on 2022-05-312022-10-05
Journal: iScience [Category] 변종, 임상,

[키워드] Algorithms Analysis approach bioinformatics clinical Clinical data clinical feature clinical variables Cluster Clustering Clusters Cohort COVID-19 dataset datasets defined disease pathogenesis GMM heterogeneous hospital identify information integration Interaction Laboratory machine Medical informatics mortality rates outcome pandemic Patient patient subgroup patients with COVID-19 Predictive prognostic reduction second wave Structure subgroup therapeutic interventions therapeutic potential to define Treatment UMAP Uniform validation cohort variable variables Viral microbiology was used with COVID-19
[DOI] 10.1016/j.isci.2022.104480 [Article Type] Research article

Newly Emerged Antiviral Strategies for SARS-CoV-2: From Deciphering Viral Protein Structural Function to the Development of Vaccines, Antibodies, and Small Molecules

SARS-CoV-2에 대한 새로 등장한 항바이러스 전략: 바이러스 단백질 구조 기능 해독에서 백신, 항체 및 소분자 개발까지

Review

Published on 2022-05-292022-09-11
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody antibody cocktail antibody treatment Antiviral caused chemical compounds clustered regularly interspaced short palindromic repeats compounds contribute coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 infection CRISPR development disease pathogenesis DNA dual exploration focus function functional Health Health crisis host cells inactive Infection inhibitors life cycle molecule monoclonal antibodies monoclonal antibody mRNA nonstructural proteins palindromic repeat Particles peptide-based Protein protein-based vaccine Protein-based vaccines Proteins provide research findings respiratory RNA vaccines SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 genome severe acute respiratory syndrome Coronavirus single-stranded Strategy structural proteins structure-function systematic review target targeted therapy targets the SARS-CoV-2 genome therapeutic option Therapeutic strategies therapy Treatment Vaccine Vaccine development Vaccines Viral viral life cycle Viral protein Viral proteins viral replication virus
[DOI] 10.3390/ijms23116083 PMC 바로가기 [Article Type] Review

Cytokines from Bench to Bedside: A Retrospective Study Identifies a Definite Panel of Biomarkers to Early Assess the Risk of Negative Outcome in COVID-19 Patients

벤치에서 병상까지 사이토카인: 코로나19 환자에서 음성 결과의 위험을 조기에 평가하기 위한 확실한 바이오마커 패널을 확인하는 후향적 연구

Observational Study

Published on 2022-04-272022-09-11
Journal: International Journal of Molecular Sciences [Category] 바이오마커, 임상,

[키워드] affected age anti-inflammatory response Bench best Biomarker Biomarkers C-reactive protein conducted correlations COVID-19 COVID-19 patient COVID-19 patients CRP cut-off cytokine Cytokines death Definite disease pathogenesis Endothelial dysfunction explain Extensive help Hospital admission Hospitalized identify IL-10 IL-1β IL-6 IL-8 immunoparalysis interferon interferon-γ interleukin interleukin 6 Intervention intubation IP10 majority marker mortality rate MR-proADM negative observational study orotracheal intubation outcome Panel Patient performed Predictive Predictive value proadrenomedullin Prognosis representing retrospective risk severe patients sIL2Rα. Stage statistical analysis synergy systemic inflammation tested TNFα variable worse prognosis
[DOI] 10.3390/ijms23094830 PMC 바로가기 [Article Type] Observational Study

Viral Mimicry of Interleukin-17A by SARS-CoV-2 ORF8

SARS-CoV-2 ORF8에 의한 인터루킨-17A의 바이러스 모방

Article

Published on 2022-04-262022-09-11
Journal: mBio [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus binding blood monocyte blood monocytes clinical presentation Clinical presentations Coagulation contribute coronavirus COVID-19 COVID-19 pathogenesis cytokine deleted disease disease pathogenesis dysregulation fibrosis Frame Gene Expression glycoprotein Host IL-17 IL-17A induce infected with SARS-CoV-2 Infection Inflammation Inflammatory response Inflammatory responses interleukin Mild milder infection mimicry molecular molecular mechanism Monocytes myriad Open reading frame ORF8 ORF8 protein outcome outcomes pathway potential therapeutic target Protein receptor reduced reveal robust SARS-CoV-2 SARS-CoV-2 variants secreted severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe inflammation Signaling significantly Transcriptome transcriptome analysis Trigger triggering upregulated variant viral IL-17. with mild disease
[DOI] 10.1128/mbio.00402-22 PMC 바로가기 [Article Type] Article

Trained Immunity: An Overview and the Impact on COVID-19

Immunology

Published on 2022-02-172022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, COVID19(2023년), MERS, SARS,

[키워드] activate alleviate approach B-glucan Bacillus BCG cell type cells clinical study clinical trials component Corona COVID-19 COVID-19 crisis COVID-19 pandemic develop disease pathogenesis effective greater Health immune immune protection immune response immune system Immunity Impact in vitro in vivo Infection Infectious disease innate immune cell innate immune system Innate immunity involved LPS mechanism monocyte Monocytes natural killer natural killer (NK) non-specific Pathogens pathway potential therapeutic target Protective respiratory SARS-CoV-2 SARS-COV-2 infection signaling pathway therapeutic target trained immunity understanding
[DOI] 10.3389/fimmu.2022.837524 PMC 바로가기 [Article Type] Immunology

Emerging Role of Platelet-Endothelium Interactions in the Pathogenesis of Severe SARS-CoV-2 Infection-Associated Myocardial Injury

중증 SARS-CoV-2 감염 관련 심근 손상의 발병에서 혈소판-내피 상호작용의 새로운 역할

Review

Published on 2022-02-042022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 치료법,

[키워드] Abnormalities ACE2 ACE2 receptor activated Activation activation of platelets Acute cardiac injury acute infection acute myocardial injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition angiotensin angiotensin-converting enzyme 2 arrhythmia calcium calcium-binding proteins cardiac complication Cardiac complications cardiac disorders cardiac injury cardiovascular cardiovascular complication cardiovascular complications cardiovascular disease cardiovascular dysfunction Clinical course Clinical outcome Coagulation contribute corona virus disease (COVID-19) coronavirus defined described disease disease pathogenesis driven by dysfunction endothelial Endotheliitis event fatal complication hypercoagulability include Infection Inflammation Interaction mechanism morbidity and mortality MOST Myocardial myocardial injury nucleocapsid nucleocapsid (N) protein occur oxygen pandemic Patient Platelet platelet activation Platelets potential mechanism potential mechanisms Prevalence Proteins respiratory risk factor Risk factors role SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 virus Sepsis severe acute respiratory syndrome Coronavirus severe disease significantly Spike protein systemic inflammation the SARS-CoV-2 virus triggering turn Vascular endothelium Viral viral spike protein virus
[DOI] 10.3389/fimmu.2022.776861 PMC 바로가기 [Article Type] Review

Detailed comparison of anatomy and airflow dynamics in human and cynomolgus monkey nasal cavity

Research article

Published on 2022-02-012022-10-05
Journal: Computers in biology and medicine [Category] 비임상,

Impairing RAGE signaling promotes survival and limits disease pathogenesis following SARS-CoV-2 infection in mice

RAGE 신호 전달 장애는 생쥐에서 SARS-CoV-2 감염 후 생존을 촉진하고 질병 발병을 제한합니다

Research Article

Published on 2022-01-252022-09-10
Journal: JCI Insight [Category] 유전자 메커니즘, 진단,

[키워드] CD45 Cell cell death Cellular and molecular mechanisms contribute Critical defined disease pathogenesis driving Efficacy end products endothelial event hyperplasia immunology IMPROVE Infection Infectious disease Inflammation initiated Innate immunity interstitial pneumonia limit lung Lung injury Lungs mediator metabolic mice molecular molecular mechanism morbidity mouse model necrotic necrotic cell death outcome oxygen oxygen saturation Pathogenesis pathology perivascular perivascular inflammation populations promote RAGE receptor receptor for advanced glycation end products replicated SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection Signaling survival therapeutic target Therapeutic treatment tissue injury Treatment triggering Viral viral loads
[DOI] 10.1172/jci.insight.155896 PMC 바로가기 [Article Type] Research Article