Effect of lockdown on digestive system cancer care amongst older patients during the first wave of COVID-19: The CADIGCOVAGE multicentre cohort studyObservational Study Published on 2022-01-012022-10-05 Journal: Digestive and liver disease : official journal of [Category] SARS, 임상, [키워드] age analysed Cancer cancer diagnosis cancers Care Cohort cohort study collected Comorbidities coronavirus disease COVID-19 decrease diagnosed Digestive cancer digestive system disease stage Effect Electronic health records First wave Health healthcare increase in lockdown Mortality mortality rate Most patient multicentre not differ observé older patient older patients pandemic Patient performed proportion Public public health retrospective Sex subgroups the patient treated Treatment [DOI] 10.1016/j.dld.2021.09.017 PMC 바로가기 [Article Type] Observational Study
ENhAncing Lifestyle Behaviors in EndometriaL CancEr (ENABLE): A Pilot Randomized Controlled TrialRandomized Controlled Trial Published on 2022-01-012022-10-05 Journal: Integrative cancer therapies [Category] SARS, 임상, [키워드] adherence age Behavior BMI Cancer concealed Controlled Controlled trial COVID-19 declined disease disease stage eligible patient Endometrial Cancer feasibility Health highest impacted Intervention intervention group majority measure nutrition occurred online questionnaire participant physical physical activity Randomized RCT recruited recruitment Registered retention Serious Adverse Event Support telehealth Treatment Trial usual care usual care alone [DOI] 10.1177/15347354211069885 PMC 바로가기 [Article Type] Randomized Controlled Trial
Amino Acid Metabolism is Significantly Altered at the Time of Admission in Hospital for Severe COVID-19 Patients: Findings from Longitudinal Targeted Metabolomics Analysis중증 COVID-19 환자의 입원 시 아미노산 대사가 크게 변경됨: 종단 표적 대사체학 분석 결과Observation Published on 2021-12-082022-09-10 Journal: Microbiology Spectrum [Category] SARS, 바이오마커, [키워드] acid acute phase addition Altered approach arginine biomarker signature Care citrulline clinical manifestation clinical manifestations Clinical severity complement complementary Course COVID-19 COVID-19 case COVID-19 cases COVID-19 patient COVID-19 patients Defense defense mechanisms Deprivation described disease Disease progression disease stage effective evaluate Evidence evidence of finding fluctuation fluctuations followed by functional Glutamine heterogeneity highlight hospitalized patient Host host defense immune response immune responses Infection inhibited knowledge Kynurenine list longitudinal longitudinal study M2 macrophage polarization Macrophage marker mechanism metabolic pathway metabolic pathways metabolism metabolite metabolites metabolomic metabolomic profiling metabolomic signature metabolomics molecular molecular mechanism molecular mechanisms ornithine outcome Pathogenesis pathogenesis of COVID-19 pathway Pathways Patient Phenylalanine profile SARS-CoV-2 SARS-COV-2 infection serum serum sample serum samples severity the disease time Tryptophan tyrosine Virus-host interactions [DOI] 10.1128/spectrum.00338-21 PMC 바로가기 [Article Type] Observation
Allelic variation in class I HLA determines CD8 + T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2Research Articles Published on 2021-11-182022-11-01 Journal: Science Immunology [Category] COVID-19, [키워드] alleles Antigen applied CD8 Cell condition cross-reactive description determine disease stage epitope Ex vivo feature generate Genotype HLA HLA class I HLA variation immune Immunological memory memory response memory T reactive reactivity recall required SARS-CoV-2 SARS-COV-2 infection sequence significantly single-cell Single-cell transcriptomics specificity T cell T cell phenotype T cell response T cells TCR Variation [DOI] 10.1126/sciimmunol.abk3070 PMC 바로가기 [Article Type] Research Articles
A rapid lateral flow immunoassay strip for detection of SARS‐CoV‐2 antigen using latex microspheresResearch Article Published on 2021-11-062022-10-30 Journal: Journal of Clinical Laboratory Analysis [Category] COVID-19, SARS, [키워드] acute respiratory syndrome addition age analyzed antibody Antigen antigen detection antigens applicability Bacterial infections cause clinical manifestation concealed conditions coronavirus COVID‐19 death decrease Detection limit Diagnosis diagnostic tests Dilution disadvantage disease stage EDC and NHS Efficiency Epidemic evaluated fixed Gender immune IMPROVE lateral flow immunoassay latex microspheres LFIA limit of detection Measures microsphere MOST offer Pneumonia point‐of‐care positive provide quarantine reproducibility Result SARS‐CoV‐2 SARS‐CoV‐2 antigen sensitivity Sensitivity and specificity specificity specimens stability tested the epidemic Vaccine virus visual method was determined was tested was used [DOI] 10.1002/jcla.24091 PMC 바로가기 [Article Type] Research Article
Diagnostic performance of rapid antigen test for COVID-19 and the effect of viral load, sampling time, subject’s clinical and laboratory parameters on test accuracyResearch article Published on 2021-10-012022-10-05 Journal: Journal of infection and public health [Category] SARS, 진단, [키워드] Accuracy Antigen Blood characteristic collected country COVID-19 COVID-19 cases COVID-19 diagnosis determinant determine Diagnosis diagnostic diagnostic test disease stage disease stages ENhance feature Features Healthcare system highest individual Laboratory laboratory parameter National pandemic Patient Predictive quantitative real-time PCR radiological random forest classification rapid antigen test Result RT-qPCR Sample SARS-CoV-2 sensitivity specificity subject’ Support SVM Swab Test transcriptase Viral load was used were used [DOI] 10.1016/j.jiph.2021.06.002 [Article Type] Research article
Assessment of COVID-19 progression on day 5 from symptoms onsetResearch Published on 2021-08-282022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] 95% CI age ALT assessment AUC cardiovascular disease characteristic clinical trial cohort study collected COVID-19 COVID-19 progression CRP defined diabete discrimination Disease progression disease stage disorder Dyspnoea epidemiological facilitate feature fixed heterogeneity homogeneity Hospitalized hospitalized patient hospitalized patients identify In-hospital death laboratory data laboratory parameter LDH majority male Male sex multivariate NLR outcome PaO parameter Patient patients with COVID-19 predict Predictive predictor predicts prognostic model Prospective public health Respiratory failure Result suffered symptoms onset the mean transfer Treatment was performed with COVID-19 [DOI] 10.1186/s12879-021-06596-5 PMC 바로가기 [Article Type] Research
Psychosocial perspectives among cancer patients during the coronavirus disease 2019 ( COVID ‐19) crisis: An observational longitudinal studyObservational Study Published on 2021-08-182022-10-04 Journal: Cancer Reports [Category] COVID19(2023년), MERS, SARS, 임상, [키워드] affecting age Anxiety Breast cancer Cancer Cancer center cancer patient Cancer patients cancer type changes in clinical observations Comorbidities coronavirus disease COVID COVID‐19 curtail Depression disease stage distress elevated evaluate evaluated exhibiting expressed Factor Factors First wave greater higher risk highest hypertension indicated Infection intravenous loneliness Lung disease medical oncology Multivariate analysis pandemic Patient patients Patients with cancer Perspective populations Psychological Psychosocial psychosocial studies Quality of life recruited reduced scale Spearman Spread Support therapy time Treatment was related were assessed [DOI] 10.1002/cnr2.1506 PMC 바로가기 [Article Type] Observational Study
The impact of tocilizumab on respiratory support states transition and clinical outcomes in COVID-19 patients. A Markov model multi-state studyCOVID-19 환자의 호흡 지원 상태 전환 및 임상 결과에 대한 토실리주맙의 영향. 마르코프 모델 다중 상태 연구Observational Study Published on 2021-08-122022-09-12 Journal: PLoS ONE [Category] 임상, 진단, [키워드] 95% CI Analysis approach benefit Clinical outcome clinical trials contributing to COVID pneumonia COVID-19 patients death Decision making disease disease stage Endpoint heterogeneous hospital IMV invasive Invasive mechanical ventilation management Markov Mortality NIV no respiratory support Non-invasive non-invasive ventilation observational study oxygen Oxygen therapy Patient positive Prevalence Probability randomized clinical trial reduced risk Respiratory Support Result sequence Support switching Time to recovery Tocilizumab tocilizumab administration treated was used [DOI] 10.1371/journal.pone.0251378 PMC 바로가기 [Article Type] Observational Study
Prolonged detection of complete viral genomes demonstrated by SARS-CoV-2 sequencing of serial respiratory specimens연속 호흡기 시편의 SARS-COV-2 시퀀싱에 의해 입증 된 완전한 바이러스 게놈의 장기 검출Research Article Published on 2021-08-052022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advanced disease can not clinically Complete confirmed case confirmed cases coronavirus COVID19 patient COVID19 patients demonstrated Diagnosis disease stage early stage gene target Infection initial mapped methodology MONITOR N gene nCoV NGS positive Prevent Prolonged RdRP Real-time PCR reduced required respiratory respiratory sample respiratory specimen SARS-CoV-2 SARS-CoV-2 sequencing sequence Sequencing severe acute respiratory syndrome Coronavirus Spread Stage stages tested the disease the SARS-CoV-2 Transcription triplex Viral viral genome viral sequence viral sequences Viral transmission whole genome [DOI] 10.1371/journal.pone.0255691 PMC 바로가기 [Article Type] Research Article