Peptides of H. sapiens and P. falciparum that are predicted to bind strongly to HLA-A*24:02 and homologous to a SARS-CoV-2 peptideH. sapiens와 P. falciparum의 펩타이드로 HLA-A*24:02에 강하게 결합할 것으로 예측되며 SARS-CoV-2 펩타이드와 유사한 펩타이드Article Published on 2021-09-012024-08-26 Journal: Acta tropica [Category] 말라리아, [키워드] Autoimmunity disease susceptibility human leukocyte antigen molecular mimicry Plasmodium SARS-CoV-2 [DOI] 10.1016/j.actatropica.2021.106013 PMC 바로가기
Genetics Insight for COVID-19 Susceptibility and Severity: A ReviewCOVID-19 감수성 및 심각도에 대한 유전학적 통찰: 검토Review Published on 2021-04-012022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] ABO ACE2 affecting allele alleles association Asymptomatic broad spectrum CCR9 Clinical course clinical manifestation clinical manifestations coronavirus coronavirus disease COVID-19 COVID-19 complication COVID-19 complications COVID-19 severity COVID-19 susceptibility CXCR6 cytokine Cytokine storm disease disease susceptibility expression FCGR2A FYCO1 genetic background Genetic variant genetic variants genetics GWAS HLA HLA-A Host IL17A IL1B IL1R1 IL1RN IL6 Infectious disease Infectious diseases insight inter-individual loci LZTFL1 mechanism outcome pathway Population receptor receptors reported review Risk factors SARS-CoV-2 several variants severity SLC6A20 SNV susceptibility the disease thrombosis thrombosis) TMPRSS2 TNF Variability variant variants Venous thrombosis with COVID-19 XCR1 [DOI] 10.3389/fimmu.2021.622176 PMC 바로가기 [Article Type] Review
Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study남성에서 생명을 위협하는 COVID-19 질병과 Toll 유사 수용체 7 변이의 연관성: 중첩 사례 대조 연구의 결과Short Report Published on 2021-03-022022-09-10 Journal: eLife [Category] SARS, 변종, 유전자 메커니즘, [키워드] affected Analysis applied Asymptomatic case-control study clinical Cohort conditioned contributing to Control COVID-19 Deleterious demonstrated disease disease susceptibility disorder Donor expression profile extreme functional gene funding GEN-COVID Gene Expression Human iceberg IFN impairment initiative investigated Italian LASSO Logistic Regression Analysis life-threatening COVID-19 disease loss-of-function male male participant male participants participant Participants Patient patients phenotype rare variant Rare variants reduction in Regression regression analysis responses SARS-CoV-2 selected Severe case severe COVID-19 subset susceptibility TLR7 toll-like receptor 7 Trial type I variant X-linked [DOI] 10.7554/eLife.67569 PMC 바로가기 [Article Type] Short Report
Host genetic effects in pneumonia폐렴의 숙주 유전적 영향Article Published on 2021-01-072022-09-11 Journal: American Journal of Human Genetics [Category] 변종, [키워드] African association Biobank Cell CFTR conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 hospitalization cystic fibrosis diagnosed disease disease susceptibility Diseases downstream Effect Electronic health record Electronic health records European fibrosis Genetic Genome-wide association study genotyped GWAS GWASs HBB Health health record highlight Host host genetic effect host genome host susceptibility hypoxia Illumina independent individual individuals Infectious disease Infectious diseases lead locus Lung disease Lung function offer p value pandemic performed Pneumonia R3HCC1L Region replicated Respiratory failure rs334 SCD severity severity of COVID-19 sickle cell Sickle cell disease subjects susceptibility UK biobank university variant variants [DOI] 10.1016/j.ajhg.2020.12.010 PMC 바로가기 [Article Type] Article
ABO / Rh-D Blood types and susceptibility to Corona Virus Disease-19 in Peshawar, PakistanOriginal Article Published on 2021-01-012022-10-29 Journal: Pakistan Journal of Medical Sciences [Category] COVID-19, [키워드] 95% CI ABO ABO blood group association Blood blood donor blood type Chi-square confirmed case Corona COVID-19 COVID-19 group cross-sectional determine disease susceptibility less Logistic regression positive proportion Rh blood group SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR susceptibility susceptible was used were used with COVID-19 [DOI] 10.12669/pjms.37.1.3655 PMC 바로가기 [Article Type] Original Article
Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infectionarticle Published on 2020-12-312024-09-01 Journal: Journal of Innate Immunity [Category] 폐렴구균 감염증, [키워드] Common genetic variants complement system disease susceptibility Inflammation single nucleotide polymorphisms Streptococcus pneumoniae [Article Type] article
COVID-19: The Effect of Host Genetic Variations on Host–Virus InteractionsReview Published on 2020-12-102023-06-15 Journal: Journal of Proteome Research [Category] MERS, SARS, [키워드] disease susceptibility exome variants host−virus interactions loss-of-function tolerance protein−protein and RNA−interactions viral entry and innate immunity pathway proteins [DOI] 10.1021/acs.jproteome.0c00637 PMC 바로가기 [Article Type] Review
Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men안드로겐 신호는 SARS-CoV-2 수용체 수준을 조절하고 남성의 심각한 COVID-19 증상과 관련이 있습니다Article Published on 2020-12-032022-09-11 Journal: Cell Stem Cell [Category] Fulltext, MERS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] 5-alpha reductase inhibitors ACE2 ACE2 expression ACE2 regulation Analysis androgen androgen signaling angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 binding Cell cell membrane Clinical data Compound COVID-19 COVID-19 patient COVID-19 risk factors COVID-19 sex bias deep learning demonstrated disease disease severity disease susceptibility Diseases drug drug re-purposing elevated embryonic embryonic stem cell enzyme Genetic variant genetic variants Health Health crisis high content screening hPSC-based disease modeling identify Infection Level lung organoid lung organoids mechanism men occur offer potential treatment option Prostate reduce reduced risk risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection model screening strategy Sex stem cell susceptibility target the cell the disease virtual drug screen. virus [DOI] 10.1016/j.stem.2020.11.009 PMC 바로가기 [Article Type] Article
In search of preventive strategies: novel high-CBD C annabis sativa extracts modulate ACE2 expression in COVID-19 gateway tissues예방 전략 찾기: 새로운 고 CBD C annabis sativa 추출물은 COVID-19 게이트웨이 조직에서 ACE2 발현을 조절합니다Research Paper Published on 2020-11-302022-08-31 Journal: Aging (Albany NY) [Category] SARS, 치료제, [키워드] ACE2 ACE2 expression ACE2 protein ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition airway Alter Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-inflammatory anti-inflammatory properties cannabidiol cannabis caused CBD coronavirus COVID-19 COVID-19 pandemic Critical curtail decrease disease disease spread disease susceptibility down-regulate Effect effective expressed gastrointestinal tract Gene Expression Health Canada help host cells human host Inflammation intestinal tissues kidney lung tissue medical cannabis modulate modulation nasal mucosa prevention strategies Protein receptor reduce mortality regulate required Research respiratory Safe SARS-CoV-2 SARS-CoV-2 entry SARS-CoV2 Serine serine protease serine protease TMPRSS2 severe acute respiratory syndrome Coronavirus Spread susceptibility testes therapeutic therapy tissue tissues TMPRSS2 Viral viral entry while working [DOI] 10.18632/aging.202225 PMC 바로가기 [Article Type] Research Paper
Risk and Protective Factors in the COVID-19 Pandemic: A Rapid Evidence MapPublic Health Published on 2020-11-242022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, [키워드] Abstract affected age and gender Analysis applied benefit children Comorbidity COVID-19 COVID-19 susceptibility demographic disease susceptibility Evidence Factor Factors generate healthcare identify include inclusion criteria knowledge literature screening male Map MOST novel Older outcome outcomes pandemic pregnant women PROTECT Protective protective factor Protective factors protocol Racial Rapid rapid evidence mapping recall reported Research risk Risk factors Spread susceptibility susceptible systematic review was used [DOI] 10.3389/fpubh.2020.582205 PMC 바로가기 [Article Type] Public Health