disease susceptibility – Communicable Diseases Research

Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibility

Research article

Published on 2022-10-012022-10-05
Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 유전자 메커니즘,

Differential Leukocyte Expression of IFITM1 and IFITM3 in Patients with Severe Pandemic Influenza A(H1N1) and COVID-19

중증 유행성 인플루엔자 A(H1N1) 및 COVID-19 환자에서 IFITM1 및 IFITM3의 차등 백혈구 발현

Article

Published on 2022-08-012022-09-11
Journal: Journal of interferon & cytokine research : the of [Category] 바이오마커, 신종인플루엔자,

[키워드] addressed characteristic Clinical characteristics Clinical outcome clinical outcomes Cohort Comparisons coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 disease disease susceptibility downregulation Endosomes evaluated Evidence expression healthy control healthy controls High-dose humans IFITM IFITM1 IFITM3 individual Infection Influenza influenza A influenza A(H1N1) leukocyte leukocytes lung Lungs membrane fusion mice Mortality mRNA expression murine model nucleotide outcome outcomes pandemic pandemic influenza participant Patient Pneumonia Protective Protein respiratory respiratory infections Single nucleotide polymorphism single nucleotide polymorphisms susceptibility transmembrane underlying disease Viral viral respiratory infection viral respiratory infections virus viruses
[DOI] 10.1089/jir.2022.0036 PMC 바로가기 [Article Type] Article

The genetic and evolutionary determinants of COVID-19 susceptibility

COVID-19 감수성의 유전적 및 진화적 결정 요인

Review

Published on 2022-08-012022-09-11
Journal: European Journal of Human Genetics [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제,

A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection

Article

Published on 2022-07-012023-07-08
Journal: Journal of the American Society of Nephrology : JA [Category] COVID19(2023년),

[키워드] acute renal failure angiotensin-converting enzyme 2 COVID-19 disease susceptibility Kidney disease mice renal protection renin angiotensin system SARS-CoV-2 Virology
[DOI] 10.1681/ASN.2021091209

Metabolic Snapshot of Plasma Samples Reveals New Pathways Implicated in SARS-CoV-2 Pathogenesis

Article

Published on 2022-03-042023-07-08
Journal: Journal of Proteome Research [Category] COVID19(2023년),

[키워드] Biomarkers clinical progression COVID-19 disease susceptibility metabolites metabolomics oxidative stress response. SARS-CoV-2
[DOI] 10.1021/acs.jproteome.1c00786

Genetic association of TMPRSS2 rs2070788 polymorphism with COVID-19 case fatality rate among Indian populations

인도 인구 중 COVID-19 사례 사망률과 TMPRSS2 rs2070788 다형성의 유전적 연관성

Article

Published on 2022-03-012022-09-11
Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 바이오마커, 변종, 유전자 메커니즘,

[키워드] ACE2 ACE2 gene ACE2 receptor Analysis analyzed antagonistic approach Asia Asians association Biomarker Case fatality rate causative agent CFR COVID-19 COVID-19 infection COVID-19 susceptibility disease disease susceptibility disparity East engage eQTL analysis expression Fatality rate Frequency G allele Genetic genetic association Genotype Haplotype help Host host cell increased expression India individual information intensity linkage Linkage disequilibrium lung Next-generation sequencing NGS observation pandemic pathogenicity Phylogenetic polymorphism Population populations positive predict priming risk rs2070788. S protein SARS-CoV-2 Serine serine protease severity significantly higher SNP South South Asian susceptibility tested the SARS-CoV-2 TMPRSS2 variant Variation West with COVID-19
[DOI] 10.1016/j.meegid.2022.105206 PMC 바로가기 [Article Type] Article

Three Specific Potential Epitopes That Could Be Recognized by T Cells of Convalescent COVID-19 Patients Were Identified From Spike Protein

회복기 COVID-19 환자의 T 세포가 인식할 수 있는 3개의 특정 잠재적 에피토프가 스파이크 단백질에서 확인되었습니다

Immunology

Published on 2022-01-282022-09-11
Journal: Frontiers in Immunology [Category] 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Amino acid amino acids antibody Antigen Chinese convalescent Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 COVID-19 convalescent patient COVID-19 convalescent patients COVID-19 patient COVID-19 vaccine COVID-19 vaccines cross-reaction detect disease disease susceptibility Efficacy epitope Epitopes flow cytometry Frequency frequency of occurrence Genotype HLA HLA allele HLA alleles Identified IFN-γ Infection information mononuclear cell neutralizing antibody nonspecific Occurrence peptide peptides Peripheral blood positive Potential Prevent provide provided reaction rate Reactions Research respiratory SARS-CoV-2 SARS-CoV-2 S protein screened Seven severe acute respiratory syndrome Coronavirus severity of COVID-19 Specific spike Spike protein subsequent susceptibility T cell T cells T-cell T-cell epitope T-cell epitopes T-cell immunity Vaccine Viral viral infection
[DOI] 10.3389/fimmu.2022.752622 PMC 바로가기 [Article Type] Immunology

The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients

인터페론 람다 3과 4 유전자 단일-뉴클레오티드 다형성 사이의 연관성과 COVID-19 환자의 회복

Research

Published on 2021-11-142022-09-10
Journal: Virology Journal [Category] MERS, SARS, 치료제,

[키워드] 25-hydroxyvitamin D acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 association C-reactive protein caused clinical parameter Clinical parameters coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 infection COVID-19 patient CRP disease disease susceptibility elevated erythrocyte sedimentation erythrocyte sedimentation rate ESR evaluate Factor Frequency Genetic genetic factors Genotype genotyped Host IFNL3 IFNL4 include Infection Interferon lambda Interferon lambda 3 Interferon lambda 4 LDL Logistic regression analysis low-density Low-density lipoprotein multivariate multivariate logistic regression analysis nonsurvivors pandemic Pathogenesis patients PCR polymerase chain polymerase chain reaction polymorphism respiratory Result SARS-CoV-2 SARS-CoV-2 positive patient sedimentation rate Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severity of COVID-19 shown significantly higher single-nucleotide Single-nucleotide polymorphisms SNP SNPs survivor susceptibility Viral Viral load
[DOI] 10.1186/s12985-021-01692-z PMC 바로가기 [Article Type] Research

Leveraging publicly available coronavirus data to identify new therapeutic targets for COVID-19

COVID-19에 대한 새로운 치료 목표를 식별하기 위해 공개적으로 사용 가능한 코로나 바이러스 데이터를 활용

Research Article

Published on 2021-09-292022-09-10
Journal: PLoS ONE [Category] MERS, SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Analysis Antiviral Asymptomatic Bioinformatic bioinformatic analysis Brain coronavirus Coronavirus-2 COVID-19 dataset disease disease susceptibility dysfunction Effects Evidence evidence of facilitate Factor Gut heart Host identify immune immune surveillance include individuals Innate immunity interferon liver long-lasting Loss of Smell lung mechanism MERS-CoV outbreak promotion question representing respiratory responsible SARS-CoV-1 SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus subversion Surveillance susceptibility therapeutic target Variability Vascular Viral viral pathogen viral replication
[DOI] 10.1371/journal.pone.0257965 PMC 바로가기 [Article Type] Research Article

Association of ABO and Rh blood groups with obstetric outcomes in SARS-CoV-2 infected pregnancies: A prospective study with a multivariate analysis

Observational Study

Published on 2021-09-012022-10-05
Journal: European journal of obstetrics, gynecology, and re [Category] SARS, 임상,