Ku Binding on Telomeres Occurs at Sites Distal from the Physical Chromosome Ends텔로미어의 Ku 결합은 물리적 염색체 말단에서 먼 부위에서 발생Research Article Published on 2016-12-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] association bind binding Cancer caused cells chromatin chromosome chromosomes complex difficulty DNA DNA binding DNA break DNA breaks DNA replication double-stranded elements elongation End facilitate finding followed by function generate Genome hallmark independent induce interstitial lead mechanism NHEJ non-homologous occur physical predict Previous studies protein-protein interaction proximal reduce Region repair Replication replication fork reported Site solution telomerase telomere telomeres transition turn yeast [DOI] 10.1371/journal.pgen.1006479 PMC 바로가기 [Article Type] Research Article
Transcription Factors Encoded on Core and Accessory Chromosomes of Fusarium oxysporum Induce Expression of Effector GenesFusarium oxysporum의 코어 및 액세서리 염색체에 인코딩된 전사 인자는 이펙터 유전자의 발현을 유도합니다Research Article Published on 2016-11-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accessory accessory chromosome accessory chromosomes activate autonomous bind binding site chromatin chromatin condensation chromosome chromosomes colonisation connection conserved constitutive promoter core core genome determine DNA binding effector effectors ENCODE Evolution example expression extreme facilitate Factor FTF1 FTF2 fungal fungi Fusarium GC content Gene Expression Genes Genome genomic genomic region homolog homolog FTF2 homologous Host independent induce Infection Interaction investigated maintain motif motifs nine occurred oligonucleotide oligonucleotide arrays outcome overlapping pathogen Pathogenesis pathogenic pathogenicity Pathogens predicted promoters reference strain Region required RNAseq analysis secreted Sge1 specificity strain Strains tomato Transcription transcription factor transcription factor gene transcription factor genes transcription factors transcriptional transcriptionally transfer transferred transposon up-regulated virulence yeast [DOI] 10.1371/journal.pgen.1006401 PMC 바로가기 [Article Type] Research Article
Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex클렙시엘라 폐렴균의 토포이소머라제 IV의 퀴놀론 안정화 절단 복합체 구조 및 관련된 폐렴구균 복합체와의 비교Research Paper Published on 2016-04-012024-07-28 Journal: Acta crystallographica. Section D [Category] 폐렴구균 감염증, [키워드] cleavage complex DNA binding Gram-negative complexes isomerase isomerase–DNA complex levofloxacin protein–DNA–drug complexes quinolone topoisomerase IV topoisomerases X-ray crystallography [DOI] 10.1107/S2059798316001212 PMC 바로가기 [Article Type] Research Paper
Systems Level Analyses Reveal Multiple Regulatory Activities of CodY Controlling Metabolism, Motility and Virulence in Listeria monocytogenes시스템 수준 분석을 통해 Listeria monocytogenes에서 대사, 운동성 및 독성을 제어하는 CodY의 여러 조절 활동이 밝혀졌습니다.Research Article Published on 2016-02-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] actA activate activator activity adaptation Affect Amino acid amino acids Analysis Bacteria bacterial pathogen Bacterial pathogens BCAA bind binding branch CodY condition conditions controlling dependent on DNA DNA binding environmental cues expression facilitate function functions Gene Expression Genes Genome gram Gram-positive bacteria growth Host identify identifying L . monocytogene Level Ligand ligands Listeria Listeria monocytogene Listeria monocytogenes mammalian metabolic genes metabolism modulate motility Multiple multiple pathway multiple pathways observation pathogen Pathogens pathway Pathways performed previous study prfA raised regulated regulator gene Regulatory regulatory network reported repress repressor respond response responses Sequencing Stress stress responses System Target genes thought traits Transcription transcription factor transcription factors virulence virulence gene virulence genes [DOI] 10.1371/journal.pgen.1005870 PMC 바로가기 [Article Type] Research Article
Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-κB SignalingArticle Published on 2015-12-172022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] activity Alpha Analysis Antiviral antiviral response Cell cells coronavirus Degradation dehydrogenase DNA binding downregulated enterovirus examined Exogenous expression G6PD glucose-6-phosphate dehydrogenase GTPase HCoV-229E HSCARG human coronavirus 229E IDH1 increased expression Infection inhibited IκB mechanism MX1 NADPH Necrosis NF-κB NF-κB signaling nicotinamide adenine dinucleotide overexpression phosphate promoter Protein reduced response resulting sensor siRNA suppressed susceptibility susceptible TNF- α upregulated viral gene expression viral infection virus infection [DOI] 10.3390/v7122966 PMC 바로가기 [Article Type] Article
The Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33Article Published on 2015-11-242023-08-30 Journal: International Journal of Molecular Sciences [Category] E형 간염, [키워드] deubiquitinase DNA binding IL-13 IL-33 ubiquitin-specific protease 17 (USP17) [DOI] 10.3390/ijms161126063 PMC 바로가기 [Article Type] Article
The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activityResearch Published on 2014-12-072022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Activation activity blocked chromatin immunoprecipitation complex interaction contribute coronavirus dependent on DNA binding downstream DUB EMSA engage experiment expressing Factors Host identify IFN Infection inhibit inhibited inhibiting inhibition activity innate immune innate immune response Innate immunity interferon IRF3 mechanism Mutagenesis mutant nuclear outcome Pathogenesis pathway Phosphorylation Plasmid PLPro potential mechanism protease Protein regulate regulated Result SARS Coronavirus SARS-CoV Severe acute respiratory syndrome shift shown Signaling Type I IFN type I interferon viral infection [DOI] 10.1186/s12985-014-0209-9 PMC 바로가기 [Article Type] Research
The Nuclear Immune Receptor RPS4 Is Required for RRS1 SLH1 -Dependent Constitutive Defense Activation in Arabidopsis thaliana핵 면역 수용체 RPS4는 Arabidopsis thaliana에서 RRS1 SLH1 -의존적 구성 방어 활성화에 필요합니다Research Article Published on 2014-10-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activate Activation Agrobacterium allele Amino acid Analysis Arabidopsis Arabidopsis thaliana Bacterial C-terminal Cell complex conducted Defense disease DNA binding domain dominant downstream effector effectors ENCODE function Genes Genetic genetic screen growth hypotheses identify Immune receptor immune receptors immune responses Immunity inactive insertion leucine loss-of-function mutation loss-of-function mutations mammalian mechanism motif mutant mutants Mutation NLR NLRs nuclear nucleotide overlap pathogen performed plant plants Protein Pseudomona Pseudomonas R genes receptor Recognition recognize required rescued responses RRS1 secretion Signaling significantly temperature transcribed transcriptional transcriptional activation transcriptional change Trigger triggers type III wild type [DOI] 10.1371/journal.pgen.1004655 PMC 바로가기 [Article Type] Research Article
Combining Quantitative Genetic Footprinting and Trait Enrichment Analysis to Identify Fitness Determinants of a Bacterial Pathogen정량적 유전 발자국과 특성 강화 분석을 결합하여 세균성 병원체의 적합성 결정 요인 식별Research Article Published on 2013-08-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major abundance Affect Algorithm Antibiotic resistance approach approaches array assortment Author Bacterial bacterial gene bacterial genes benefit bioinformatics candidate gene changes in Combination conjunction conserved dataset deep sequencing deleted determinant determinants Determining diagnostic dissect Diversity DNA binding E. coli effective effort enrichment Escherichia Escherichia coli Factor fitness Follow-up analysis Footprinting found Gene Genes Genetic Genome genomes highest highlight homologue homologues Host hypothetical identify increasingly independent Infection infections insertion investigator investigators isolates Meningitis molecular mouse model Mutagenesis mutant novel observation observations pathogen Pathogenesis pathogenic pathogenic strain pathogenic strains Pathogens phenotypic phenotypic variation phylogenetic distribution promote Quantitative reported required Research resource saturated Sepsis Sequencing shown strain Strains suggested therapeutic therapeutic targets Therapies Tn-seq to define trait transcriptional repressor transposon urinary tract infections variant Variation virulence virulence gene widespread zebrafish [DOI] 10.1371/journal.pgen.1003716 PMC 바로가기 [Article Type] Research Article