STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)
STING 효능제 diABZI, PANoptosis 및 DNA 매개 급성 호흡 곤란 증후군(ARDS) 유도
Article
[키워드] Activation
acute lung inflammation
acute respiratory distress
AIM2
airway
amplification
amplifying
Apoptosis
apoptosis induction
ARDS
CASP8
caspase-3
cell death
cGAS
cleavage
complex
contribute
Cytokines
cytoplasm
DDX41
dinucleotide
Disruption
DNA
DNase I
double-stranded
dsDNA
ENhance
epithelial
extracellular DNA
followed by
gasdermin D
IFN
IFN-I
IFNAR1
IL-1β
IL-6
immune response
immune responses
induce
Infection
inflammasomes
Inflammation
Inflammatory
Inflammatory cytokine
Inflammatory cytokines
Inflammatory response
interferon
IRF3
low dose
lung
Lung inflammation
mice
MLKL
necroptosis
NET
NETosis
neutrophilic
neutrophilic response
NF-kB
NF-kB pathway
NLRP3
NLRP3 inflammasome
nucleotide
pathway
Phosphorylation
priming
pro-inflammatory cytokine
pro-inflammatory cytokines
pyroptosis
receptor
RIPK3
SARS-COV-2 infection
severe ARDS
signaling pathway
silica
smoke
stimulator
STING
subsequent
suggested
syndrome
TBK1
therapeutic strategy
TLR9
TNFR1
TNFα
Treatment
triggered
Tumor
tumors
Type I IFN
type I IFN response
type I interferon
upregulation
viral infection
ZBP1
[DOI] 10.1038/s41419-022-04664-5 PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41419-022-04664-5 PMC 바로가기 [Article Type] Article