double-stranded RNA

[키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect airway airways alveolar alveolar epithelial cell bronchial epithelial cell C57BL/6 Calu Calu-3 cell calu-3 cells chronic obstructive chronic obstructive pulmonary disease cigarette smoke Control controls COPD coronavirus coronavirus 2 determined by disease double-stranded RNA dsRNA Effect ELISA entry receptor epithelia epithelial cells evaluated expression of SARS-CoV-2 HBECs human bronchial epithelial cells immunofluorescence immunofluorescence staining immunostaining in vitro In vitro infection in vivo independent Infection inhibited investigated mice mRNA level mRNA levels N protein obstructive pulmonary disease Patient Plaque assay pulmonary disease qPCR receptor ACE2 replicative respiratory Result RT-qPCR SARS-CoV-2 entry receptor SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity staining supplementary material TMPRSS2 Treatment Viral viral replication western blot
[DOI] 10.1186/s12890-021-01639-8 PMC 바로가기 [Article Type] Research