Analysis of Emerging Variants of Turkey Reovirus using Machine LearningProblem Solving Protocol Published on 2024-05-152024-09-05 Journal: Briefings in Bioinformatics [Category] update2024, [키워드] double-stranded RNA machine learning Reovirus analysis reovirus classification [DOI] 10.1093/bib/bbae224 PMC 바로가기 [Article Type] Problem Solving Protocol
Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activityResearch article Published on 2022-08-242022-10-05 Journal: Molecular Therapy. Nucleic Acids [Category] 치료제, [키워드] acute respiratory syndrome antiviral activity antiviral response antiviral therapeutic antiviral therapeutics base base pairs blunt cell lines Characteristics coronavirus coronavirus disease COVID-19 described DNA double-stranded RNA dsRNAs groups highlight Hoogsteen G-G base pairing human lung IFN IFN-I IFN-III immunostimulant immunostimulatory immunostimulatory RNA independent induce Infection Influenza influenza A virus interferon lack lung MERS-CoV Middle East monophosphate motif MT: Oligonucleotides not affect organ on a chip pandemic pathophysiology pathway proinflammatory receptor respiratory syndrome coronavirus respiratory virus RIG-I RNA RNAs SARS-CoV SARS-CoV-2 SARS-COV-2 infection sequence siRNAs terminal hydroxyl Therapies and Applications TLR type I type III interferon unique [DOI] 10.1016/j.omtn.2022.08.031 [Article Type] Research article
SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patientsSARS-CoV-2는 시험관 내 및 COVID-19 환자에서 1차 인간 면역계 세포를 생산적으로 감염시킵니다Article Published on 2022-08-172022-09-11 Journal: Journal of Molecular Cell Biology [Category] SARS, 진단, 치료기술, 치료법, [키워드] accumulating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Apoptosis appear B and T lymphocytes B cells B lymphocyte B lymphocytes CD4+ T lymphocyte Cell circulating leukocytes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cytokine storm disease pathogenesis disease severity double-stranded RNA expressive flow cytometry hallmark Host Human immune system hyperinflammatory state Immune cell immune cells immune dysfunction immunofluorescence analysis implication in vitro indicated infect Infection inflammatory state leukocyte leukocytes lung tissue Lymphocytes lymphocytopenia monocyte Monocytes mononuclear cell mononuclear cells outcome patients PBMC Peripheral blood Peripheral blood mononuclear cell (PBMC) Peripheral blood mononuclear cells Prognosis progression Replication respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro severe acute respiratory syndrome Coronavirus susceptible sustained symptom onset T cell T lymphocytes Viral viral replication Viral RNA virus spread [DOI] 10.1093/jmcb/mjac021 PMC 바로가기 [Article Type] Article
Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine StimulationDiscovery Proteomics 분석을 통해 드라이버 종양유전자가 인터페론-β 자가분비 자극 감소를 통해 항바이러스 방어 경로를 억제한다는 사실이 확인되었습니다.Article Published on 2022-07-012022-09-11 Journal: Molecular & Cellular Proteomics : MCP [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] activated AKT Antiviral approach autocrine BRAF c-MYC Cancer cancer cell line cancer cell lines cancers Cell cell line cellular DDX58 develop double-stranded double-stranded RNA downregulation driven by driving dsRNA EGFR expression functional hallmark HER2 immune evasion Infection interferon KRAS lower expression MEK molecular MYC OAS oncogene oncogenes. oncogenic osteosarcoma Pancreatic cancer phenotypic profiles Protein Proteins proteome provide reduced regulated response RIG-I RNA virus SARS-CoV-2 shown Stimulation susceptibility susceptibility to infection therapeutic treated type 1 interferon [DOI] 10.1016/j.mcpro.2022.100247 PMC 바로가기 [Article Type] Article
Immunofluorescence-Mediated Detection of Respiratory Virus Infections in Human Airway Epithelial CulturesArticle Published on 2022-06-012022-11-15 Journal: Current protocols [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome Air-liquid interface airway airway epithelial cell airway epithelium Analysis antibody basic Cell Cell culture cell tropism cellular coronavirus Culture current death detection determine double-stranded RNA Effect Efficiency epithelial Factor feature Generation Host Human human airway epithelial immortalized cell line immunofluorescence immunofluorescence microscopy in vivo include infect infected cell infected individual Infection Influenza virus LLC Microscopy Mild mucosal epithelium pathogen Periodical phenotype protocol respiratory respiratory tract respiratory virus rhinovirus Spread Symptom target upper respiratory tract viral pathogen virus [DOI] 10.1002/cpz1.453 PMC 바로가기
No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccinationCOVID-19 mRNA 백신 접종 후 태아 결함 또는 항-싱시틴-1 항체 유도의 증거 없음Article Published on 2022-05-242022-09-11 Journal: PLoS Biology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome coronavirus age anti-RBD anti-receptor-binding domain Anti-spike antibody antibody status birth defects circulating Cohort coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mRNA Vaccination crown-rump length detect determine double-stranded RNA early pregnancy elevated ELISA Fertility fetal gestational age growth immunization impacted in utero incidence infertility injection intramuscular investigated lead levels of antibody maternal antibody mice mouse model mRNA mRNA vaccination murine Neonatal no evidence of observé outcomes Placenta placental poly(I:C poly(I:C) polyinosinic-polycytidylic acid Pregnancy Protein public interest reduced respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Stage term TLR3 Topic transfer vaccination Volunteer weight [DOI] 10.1371/journal.pbio.3001506 PMC 바로가기 [Article Type] Article
Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis세포내 및 형태학적 분석을 통한 SARS-CoV-2에 대한 플리티뎁신의 항바이러스 활성 규명Article Published on 2022-04-012022-09-11 Journal: Antiviral Research [Category] Coronavirus, COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] absence Affect Alpha Analysis antitumor agent Antiviral antiviral activity antiviral drugs Antiviral treatment approach biogenesis block caused Cell Complete coronavirus COVID-19 double-stranded RNA dsRNA Efficacy electron electron microscopy elongation factor eukaryotic translation evaluate the effect Extracellular genome replication group host protein infected Vero E6 cells Interaction labeling mechanism mechanism of action Microscopy morphogenesis Morphological morphological analysis New coronavirus new coronavirus SARS-CoV-2 offer organelle pandemic plasma membrane Plitidepsin Post-infection progeny Protein provided SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid shown Structure subcellular Support target TEM transmission electron microscopy treated unique Vero E6 Vero E6 cell VERO E6 cells Vesicle viral infection Viral particles viral replication virion virus viruses [DOI] 10.1016/j.antiviral.2022.105270 PMC 바로가기 [Article Type] Article
Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN408 Published on 2022-02-142022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] 3′ end acute respiratory syndrome analyses antiviral drug attenuate bind binding biochemical assay biochemically cofactor complex coronavirus CoV CoVs crystal structure demonstrated double-stranded RNA drug enzyme exonuclease Exoribonuclease extension function high-resolution structure host immune responses implicated in viral inhibitors Innate immunity mechanism modeling molecular Molecular dynamics simulation molecular dynamics simulations N-terminal nonstructural protein 14 nsp14 nsp14-ExoN nucleotide platform polymerase Proofreading RdRP regulated Replication residue RNA RNA genome RNA primer RNA recombination RNA synthesis RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 replication Significance Structure substrate Support the SARS-CoV-2 Viral protein Viral RNA viral RNA synthesis Viral virulence X-ray crystallography [DOI] 10.1073/pnas.2106379119 PMC 바로가기 [Article Type] 408
Alu RNA Structural Features Modulate Immune Cell Activation and A-to-I Editing of Alu RNAs Is Diminished in Human Inflammatory Bowel DiseaseImmunology Published on 2022-01-202022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, [키워드] A-to-I editing activate Altering Alu Alu RNA Analysis Autoimmune disease biological activity Cell Consequences COVID-19 Deamination Degradation demonstrated diminished disrupt double-stranded RNA dsRNA dsRNAs element form Human human disease include increase inflammatory bowel diseases Influenza inhibit innate immune activation innate immune response Inosine IRF IRF responses leukocyte multiple sclerosis NF-kB NF-kB responses nuclear nucleotide sequence Prevent retrotransposon RIG-I RNA RNA binding proteins RNAs SINE stimulate structure-function therapeutic potential transcriptional activity viral disease widespread [DOI] 10.3389/fimmu.2022.818023 PMC 바로가기 [Article Type] Immunology
Detection of A-to-I RNA Editing in SARS-COV-2SARS-COV-2에서 A-to-I RNA 편집 검출Article Published on 2021-12-232022-09-10 Journal: Genes [Category] SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] ADAR change clinical samples Course COVID-19 patient COVID-19 patients Deamination detection double-stranded RNA events exonic regions experiment Genome human cell line identify innate immune response majority metatranscriptomic modulating nonsynonymous RNA RNA editing RNAseq RNAseq data SARS-CoV-2 SARS-CoV-2 genomes target therapeutic interventions Transcriptome Vero Cell Vero cells Viral viral genome virus–host interaction while [DOI] 10.3390/genes13010041 PMC 바로가기 [Article Type] Article