downregulation – Page 2 – Communicable Diseases Research

Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study

Research article

Published on 2022-08-242022-10-05
Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 진단,

Identification of key molecules in COVID-19 patients significantly correlated with clinical outcomes by analyzing transcriptomic data

Article

Published on 2022-08-222022-11-15
Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료제,

[키워드] Admission Analysis analyzed Antiviral antiviral immune response antiviral immune responses caused clinical feature Clinical outcome clinical outcomes Cluster CMPK2 correlated correlation COVID-19 COVID-19 clusters COVID-19 patient COVID-19 patients CXCL10 D-dimer levels dataset datasets DEGs differentially expressed gene downregulation elevated EPSTI1 expressed expression expression profile Gene expression profiling Genes HERC6 human host cells ICU identification Ifi44 IFI44L IFI6 immune immune regulation intensive care intensive care unit Invasion involved leukocyte mechanical ventilatory support modulate nasopharyngeal OAS1 OAS2 OAS3 OASL outcome reducing RSAD2 SARS-CoV-2 SARS-COV-2 infection SERPING1 severity of COVID-19 significantly tissue transcriptomic data upregulated ventilatory viral loads
[DOI] 10.3389/fimmu.2022.930866 PMC 바로가기

SARS-CoV-2 Brain Regional Detection, Histopathology, Gene Expression, and Immunomodulatory Changes in Decedents with COVID-19

코로나19 사망자의 SARS-CoV-2 뇌 부위 검출, 조직병리학, 유전자 발현 및 면역조절 변화

Article

Published on 2022-08-162022-09-11
Journal: Journal of neuropathology and experimental neurolo [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] Amygdala arising Autopsies Autopsy Blood Brain brains cerebellar cortex change Control COVID-19 COVID-19 cases cytokine Deafferentation detection Differentially expressed genes downregulation Encephalitis fraction Gene Expression Genes Hemorrhagic hemorrhagic encephalitis Histopathology immune immune response indicated involved marker microglia mucosa neuronal Non-COVID-19 olfactory olfactory bulb portal receptor reduced reduction Region Regional RNA polymerase RNA sequence RNA sequences RNA-dependent RNA polymerase RNAseq RT-PCR S gene SARS-CoV-2 SARS-CoV-2 E gene sequence serum Significant subject upregulation viral sequence virus with COVID-19
[DOI] 10.1093/jnen/nlac056 PMC 바로가기 [Article Type] Article

Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patients

Article

Published on 2022-08-112022-11-15
Journal: Frontiers in Immunology [Category] SARS, 치료제,

[키워드] 95% CI adaptive immune responses Angiogenesis antiviral response antiviral responses asymptomatic infection AUROC Biomarker Biomarkers chemokines circulating miRNA clinical condition collected Combination COVID-19 COVID-19 pathogenesis COVID-19 patient DE miRNA death differentially expressed disease disease severity downregulation driven by experiment Genes healthy control heart failure highlighting Hospital admission human cell impairment in vitro induce Inflammation inhibit Innate immunity interferon involved leukocyte life threatening Lung disease Lung epithelial cells Lung fibrosis microRNA Mild miR-4433b-5p miRNA miRNA signature miRNAs moderate modulated Mortality organ damage outcome Patient predicted pro-inflammatory cytokine pro-inflammatory factors provided RNA-sequencing SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity serum serum sample severe COVID-19 severe disease severity Stress subset the cytokine storm upregulation Vascular damage was performed with COVID-19
[DOI] 10.3389/fimmu.2022.968991 PMC 바로가기

DOCK2 is involved in the host genetics and biology of severe COVID-19

Research

Published on 2022-08-082022-10-05
Journal: Nature [Category] SARS, 변종, 유전자 메커니즘,

[키워드] age Analysis Biomarker characterized chromosome Cohort collected conducted controls COVID-19 decreased expression DOCK2 downregulation dysregulated East Asian Europeans expression Factor Genetic Genome-wide association study GWAS highlighting Host host genetics Host immune response identifying individual individuals initial involved Japanese less lung Macrophage Non-classical monocytes oedema pandemic Patient Peripheral blood Pneumonia populations prevalent recruitment responses risk allele RNA-sequencing SARS-COV-2 infection Severe case severe COVID-19 Severe COVID-19 pneumonia severity specimen suppressed therapeutic target type I interferon variant viral loads weight loss younger patients
[DOI] 10.1038/s41586-022-05163-5 [Article Type] Research

Repurposing the antibacterial drugs for inhibition of SARS-CoV2-PLpro using molecular docking, MD simulation and binding energy calculation

분자 도킹, MD 시뮬레이션 및 결합 에너지 계산을 사용하여 SARS-COV2-PLPRO의 억제를위한 항균제를 재사용

Article

Published on 2022-08-012022-08-31
Journal: Molecular diversity [Category] SARS, 신약개발,

[키워드] acetic acid Amino acid amino acids Antibacterial Antibacterial compounds aromatic rings benzofuran best binding energy cleavage collected complex Compound conserved docked downregulating downregulation drug effective effective inhibitor feature filtered function GRL0617 Host hydrophobic hydrophobic interaction immune system indol inhibitor Interaction interferon interferon-stimulated gene IRF3 ISG15 key amino acid key amino acids MD simulation molecular molecular docking molecular dynamics Molecular dynamics simulation non-structural protein novel corona virus Papain Papain-like protease Papain-like protease (PLpro) PLPro produced promoted protease Protein protein-ligand Proteins removal Replication reported repurposing SARS-CoV SARS-CoV-2 SARS-CoV-2 novel corona virus. SARS-CoV2 similarity stability type I interferon Viral viral growth Zinc ZINC database
[DOI] 10.1007/s11030-021-10325-0 PMC 바로가기 [Article Type] Article

Deregulation of ceRNA Networks in Frontal Cortex and Choroid Plexus of Brain during SARS-CoV-2 Infection Aggravates Neurological Manifestations: An Insight from Bulk and Single-Cell Transcriptomic Analyses

SARS-CoV-2 감염 중 뇌의 전두엽 피질 및 맥락총 신경총에서 ceRNA 네트워크의 규제 완화는 신경 증상을 악화시킵니다: 대량 및 단일 세포 전사체 분석의 통찰력

Article

Published on 2022-08-012022-09-11
Journal: Advanced Biology [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] Analysis analyzed Brain cell type cell types choroid Choroid plexus competing competing endogenous RNA network cortex deregulated differentially expressed downregulated downregulation downstream excitatory explain Frontal Gene Expression help Human brain impairment indicated Initially insight landscape lncRNA MALAT1 mapping mechanism MIRLET7BHG miRNA miRNAs mRNA NEAT1 network neurological Neuron neurons NorAD pathway enrichment Plexus reconstructed regulatory circuit RNA RNA-Seq SARS-CoV-2 single-cell RNA-seq STXBP5 STXBP5-AS1 therapeutic Therapeutics transcriptomic upregulated upregulation Variability
[DOI] 10.1002/adbi.202101310 PMC 바로가기 [Article Type] Article

Differential Leukocyte Expression of IFITM1 and IFITM3 in Patients with Severe Pandemic Influenza A(H1N1) and COVID-19

중증 유행성 인플루엔자 A(H1N1) 및 COVID-19 환자에서 IFITM1 및 IFITM3의 차등 백혈구 발현

Article

Published on 2022-08-012022-09-11
Journal: Journal of interferon & cytokine research : the of [Category] 바이오마커, 신종인플루엔자,

[키워드] addressed characteristic Clinical characteristics Clinical outcome clinical outcomes Cohort Comparisons coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 disease disease susceptibility downregulation Endosomes evaluated Evidence expression healthy control healthy controls High-dose humans IFITM IFITM1 IFITM3 individual Infection Influenza influenza A influenza A(H1N1) leukocyte leukocytes lung Lungs membrane fusion mice Mortality mRNA expression murine model nucleotide outcome outcomes pandemic pandemic influenza participant Patient Pneumonia Protective Protein respiratory respiratory infections Single nucleotide polymorphism single nucleotide polymorphisms susceptibility transmembrane underlying disease Viral viral respiratory infection viral respiratory infections virus viruses
[DOI] 10.1089/jir.2022.0036 PMC 바로가기 [Article Type] Article

Exercise-induced myokines downregulates the ACE2 level in bronchial epithelial cells: Implications for SARS-CoV-2 prevention

운동 유도 미오카인은 기관지 상피 세포에서 ACE2 수준을 하향 조절합니다: SARS-CoV-2 예방에 대한 의미

Article

Published on 2022-07-202022-09-11
Journal: PLoS ONE [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] A549 ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal models applied approach approaches Bronchial epithelium cancer cell line Cell Cell culture cell culture study cell line centrifugation condition conditioned media controls COVID-19 pandemic culture system cytokine Cytokines death rate decrease demonstrated downregulate downregulation Effect ELISA ELISAs enzyme enzyme-linked immunosorbent assay epidemiological studies epithelial exercise exposure to expression form generate highlighting human lung immortalized lung cancer marker mass spectroscopy media mitigate modulating mRNA myokine pandemic Part PCR physical activity potential therapeutic target potential therapeutic targets priming protective effect protein level proteomic Proteomic analysis public health pulse Quantitative quantitative real-time PCR Quantitative RT-PCR receptor reduction remained replicated respiratory viruses rigor risk of infection RT-PCR SARS-CoV-2 sensitivity Serine shown Skeletal muscle skeletal muscles stimulated the SARS-CoV-2 TMPRSS2 TMPRSS2 protein transmembrane serine protease transmembrane serine protease 2 treated Treatment vaccination Vaccinations virulent virus was performed while
[DOI] 10.1371/journal.pone.0271303 PMC 바로가기 [Article Type] Article

Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine Stimulation

Discovery Proteomics 분석을 통해 드라이버 종양유전자가 인터페론-β 자가분비 자극 감소를 통해 항바이러스 방어 경로를 억제한다는 사실이 확인되었습니다.

Article

Published on 2022-07-012022-09-11
Journal: Molecular & Cellular Proteomics : MCP [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법,

[키워드] activated AKT Antiviral approach autocrine BRAF c-MYC Cancer cancer cell line cancer cell lines cancers Cell cell line cellular DDX58 develop double-stranded double-stranded RNA downregulation driven by driving dsRNA EGFR expression functional hallmark HER2 immune evasion Infection interferon KRAS lower expression MEK molecular MYC OAS oncogene oncogenes. oncogenic osteosarcoma Pancreatic cancer phenotypic profiles Protein Proteins proteome provide reduced regulated response RIG-I RNA virus SARS-CoV-2 shown Stimulation susceptibility susceptibility to infection therapeutic treated type 1 interferon
[DOI] 10.1016/j.mcpro.2022.100247 PMC 바로가기 [Article Type] Article