Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19Article Published on 2022-09-062022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 진단, [키워드] alarmin antiviral response approach binding blood leukocyte characterized COVID-19 COVID-19 pathogenesis differentially expressed down-regulation driver expression humans Immunity immunopathology JAK-STAT pathway knockout lincRNA lncRNA long noncoding RNA LUCAT1 monocyte Monocytes naïve NF-κB NF-κB-dependent gene noncoding RNA nuclear promote promoter pseudogene PU.1 Release remained RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Single-cell RNA sequencing single-cell RNA-seq Stat1 suggested systemic immune response target Transcription transcription factor transcription factors transcriptional transgene viral infection [DOI] 10.1073/pnas.2120680119 PMC 바로가기
Phylogenomic analysis of the monkeypox virus (MPXV) 2022 outbreak: Emergence of a novel viral lineage?Article Published on 2022-09-012022-11-15 Journal: Travel medicine and infectious disease [Category] 진단, [키워드] affecting Analysis B.1 B.1 lineage characterized clade clinical manifestation community transmission confirmed case COVID-19 pandemic demonstrated determine driver emergence epidemiological Europe Evolution exceptional Factor generate Genome genomic globe help humans include information lineage B.1 measure mitigate Monkeypox Monkeypox virus multifactorial outbreak pathogen performed Phylogenomic analysis public health Region reported resource Spread Surveillance sustained Transmission dynamics unique vaccination virus zoonotic disease [DOI] 10.1016/j.tmaid.2022.102402 PMC 바로가기
Mechanistic insights into global suppressors of protein folding defectsArticle Published on 2022-08-292022-11-16 Journal: PLoS Genetics [Category] SARS, 변종, 유전자 메커니즘, [키워드] accelerate aggregation amino acid substitution bacterial toxin caused characterized Combination crystal structure driver Effects ENhance Evolution examined facilitate functional protein in vitro in vivo inactive increase in Isolation loss-of-function loss-of-function mutations mechanism molecular interaction MOST mutants Mutation Neutral observé parameter Phenotypes promote Protein responsible shown stability suppressor suppressor mutation the SARS-CoV-2 thermodynamic while wildtype [DOI] 10.1371/journal.pgen.1010334 PMC 바로가기
Measuring the impact of social-distancing, testing, and undetected asymptomatic cases on the diffusion of COVID-19사회적 거리두기, 검사, 무증상 감염자가 코로나19 확산에 미치는 영향 측정Article Published on 2022-08-252022-09-11 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] Asymptomatic Asymptomatic case Asymptomatic cases category Characteristics confirmed cases country COVID-19 detection rate determine diffusion driver effective Factors infected case infected cases internal and external social distancing South Korea speed suggested suppress susceptible Taking The United States unique United States [DOI] 10.1371/journal.pone.0273469 PMC 바로가기 [Article Type] Article
Effects of side-effect risk framing strategies on COVID-19 vaccine intentions: a randomized controlled trialRandomized Controlled Trial Published on 2022-08-162022-10-05 Journal: eLife [Category] 임상, [키워드] Adding Affect behavior change change clinical conducted COVID-19 COVID-19 vaccine driver Effect Epidemiology Evidence fear global health Human independent individual Mortality nudges participant population level presenting Randomized controlled trial receive reduce registry risk Risk communication Safe severity Side-effect the United State the vaccine Trial United Kingdom Vaccine Vaccine hesitancy vaccine intention [DOI] 10.7554/eLife.78765 PMC 바로가기 [Article Type] Randomized Controlled Trial
Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions Research Published on 2022-08-152022-10-05 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] bidirectional driver epidemiological Generalizability genomic investigated Jordan Middle East pandemic Regional regions relative contribution risk SARS-CoV-2 SARS-CoV-2 transmission shifting Transmission transmission of SARS-CoV-2 Transport Travel [DOI] 10.1038/s41467-022-32536-1 [Article Type] Research
Drivers of avian habitat use and detection of backyard birds in the Pacific Northwest during COVID-19 pandemic lockdowns Research Published on 2022-08-112022-10-05 Journal: Scientific Reports [Category] 치료기술, [키워드] affected analyzed Bird changes in Community COVID-19 pandemic driver Effect exhibited Human initial intensity Local lockdown lockdown restriction lockdowns platform reduced response stressors Support unique Volunteer [DOI] 10.1038/s41598-022-16406-w [Article Type] Research
COVID-19 pandemic dynamics in South Africa and epidemiological characteristics of three variants of concern (Beta, Delta, and Omicron)남아프리카 공화국의 COVID-19 대유행 역학 및 세 가지 우려 변종(베타, 델타 및 오미크론)의 역학적 특성Article Published on 2022-08-092022-09-11 Journal: eLife [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition African Beta Characteristics coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 pandemic Delta disease driver epidemiological epidemiological data Epidemiology estimate global health help immune immune evasion independent Infection infection rate Model New coronavirus nine None Nonpharmaceutical interventions omicron pandemic parameter public health quantification Reinfection reinfection rate retrospective risk SARS-CoV-2 SARS-CoV-2 transmission severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 South South Africa trajectory Transmissibility vaccination variant variant of concern variants of concern VoC VOCs [DOI] 10.7554/eLife.78933 PMC 바로가기 [Article Type] Article
SARS-CoV-2 RT-PCR positivity in relation to clinical and demographic characteristics in residents of border quarantine centres, Khyber Pakhtunkhwa, Pakistan: a prospective cohort study파키스탄 Khyber Pakhtunkhwa 국경 검역소 거주자의 임상 및 인구 통계학적 특성과 관련된 SARS-CoV-2 RT-PCR 양성: 전향적 코호트 연구Article Published on 2022-08-052022-09-11 Journal: Transactions of the Royal Society of Tropical Medi [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted odds ratio adjusted odds ratios age Analysis association Asymptomatic asymptomatic infection calculate calculated Chain Reaction conducted coronavirus COVID-19 demographic characteristics driver effective groups hazard ratio hazard ratios healthy higher odd higher odds individual individuals Infection International Isolation Kaplan-Meier Kaplan-Meier curve Kaplan-Meier curves less Logistic regression Mantel-Haenszel Measures Older age Pakistan Period period prevalence polymerase chain polymerase chain reaction positive pre-symptomatic Prevalence primary source prospective cohort study quarantine remained reverse transcription SARS-CoV-2 SARS-CoV-2 RT-PCR Sex significantly tested Time-to-event Transmission TTE variants was used were assessed [DOI] 10.1093/trstmh/trac057 PMC 바로가기 [Article Type] Article
Communicating about COVID-19 vaccine development and safetyRandomized Controlled Trial Published on 2022-08-052022-10-05 Journal: PLoS ONE [Category] 임상, [키워드] assigned belief Communicating conducted control group COVID-19 COVID-19 mRNA vaccines COVID-19 vaccine COVID-19 vaccine development driver experiment expressed Factor identify IMPROVE Intention Intervention MOST promote Randomly reduce refusal Research risk significantly tested the vaccine vaccination intentions Vaccine vaccine intentions veteran with COVID-19 [DOI] 10.1371/journal.pone.0272426 PMC 바로가기 [Article Type] Randomized Controlled Trial