Key genetic elements, single and in clusters, underlying geographically dependent SARS-CoV-2 genetic adaptation and their impact on binding affinity for drugs and immune control지리적으로 의존적인 SARS-CoV-2 유전자 적응의 기초가 되는 단일 및 클러스터의 주요 유전 요소 및 약물 및 면역 조절에 대한 결합 친화도에 미치는 영향Article Published on 2021-01-192022-09-11 Journal: Journal of Antimicrobial Chemotherapy [Category] 변종, 치료제, [키워드] (RdRp acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 America amino acids analogues analysed antigenicity Asia B cell best binding affinity chymotrypsin Chymotrypsin-like protease circulation class close monitoring Cluster Clustering Clusters Compound Coronavirus-2 country drug drug susceptibility drugs Effectiveness element elements epitope Epitopes Europe evaluate FDA-approved drug FDA-approved drugs Genetic Hierarchical hierarchical clustering highlighting immune inhibitor modulate modulating Mutation Neutralizing antibodies neutralizing antibody occurred Oceania Penciclovir predicted protease purine purine analogue RdRP RdRp inhibitor Recognition reduced Remdesivir RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 sequence SARS-CoV-2 sequences severe acute respiratory syndrome Coronavirus specific mutation specific mutations stability tenofovir the binding affinity Treatment Vaccine Viral Viral proteins Virtual screening was used were assessed [DOI] 10.1093/jac/dkaa444 PMC 바로가기 [Article Type] Article
Clinico-microbiological profile of Burkholderia cepacia keratitis: a case seriesResearch Published on 2021-01-072024-09-02 Journal: Annals of Clinical Microbiology and Antimicrobials [Category] 대상포진, [키워드] Burkholderia cepacia corneal ulcer drug susceptibility keratitis [DOI] 10.1186/s12941-020-00407-6 PMC 바로가기 [Article Type] Research
Functional neuraminidase inhibitor resistance motifs in avian influenza A(H5Nx) virusesResearch Paper Published on 2020-10-012023-05-22 Journal: Antiviral Research [Category] Fulltext, 조류인플루엔자, [키워드] chickens drug susceptibility influenza viruses neuraminidase inhibitors [DOI] 10.1016/j.antiviral.2020.104886 PMC 바로가기 [Article Type] Research Paper
Advances in Molecular Diagnosis of TuberculosisMinireview Published on 2020-08-052022-10-30 Journal: Journal of Clinical Microbiology [Category] COVID-19, [키워드] Accuracy advance Care clinician country Culture detect diagnostics disease drug resistance drug susceptibility effective evaluated faster gene mutation Health help IMPROVE Laboratory molecular molecular test mycobacterial NAAT Next-generation sequencing nucleic acid amplification Patient phenotypic point-of-care populations receive reported smear microscopy TB patient Treatment Tuberculosis WHO with HIV World Health Organization [DOI] 10.1128/JCM.01582-19 PMC 바로가기 [Article Type] Minireview
Etiologies of diarrhea and drug susceptibility patterns of bacterial isolates among under-five year children in refugee camps in Gambella Region, Ethiopia: a case control study에티오피아 감벨라 지역 난민 캠프에서 5세 미만 아동의 설사 원인 및 세균 분리체의 약물 감수성 패턴: 사례 대조 연구Research Article Published on 2019-11-282024-07-30 Journal: BMC Infectious Diseases [Category] 세균성이질, [키워드] diarrhea drug susceptibility etiologies refugees under-five children [DOI] 10.1186/s12879-019-4599-6 PMC 바로가기 [Article Type] Research Article
Susceptibility of Influenza A, B, C, and D Viruses to Baloxavir 1Article Published on 2019-10-012023-05-31 Journal: Emerging Infectious Diseases [Category] Fulltext, 조류인플루엔자, [키워드] Avian Influenza baloxavir baloxavir marboxil drug susceptibility H7N9 highly pathogenic viruses influenza viruses Pandemic potential respiratory infections United States viruses zoonoses zoonotic influenza [DOI] 10.3201/eid2510.190607 PMC 바로가기
Next generation sequencing of HIV-1 protease in the PIVOT trial of protease inhibitor monotherapy프로테아제 억제제 단독 요법의 PIVOT 시험에서 HIV-1 프로테아제의 차세대 시퀀싱Article Published on 2018-04-012022-09-06 Journal: Journal of Clinical Virology [Category] Communicable Disease, [키워드] Algorithm Antiretroviral therapy clinically Combination combination therapy Coverage described drug drug susceptibility Evidence examined frequencies Frequency frozen plasma Highlights HIV HIV-1 Laboratory leads Local low frequency median time Median viral load methodology monotherapy Mutation mutations next generation sequencing NGS objective Patient patients performed phenotypic plasma sample predict predicted Primary outcome protease Protease inhibitor Public Health England randomisation randomised reported resistance Result Ritonavir Sanger sequencing selected Sequencing Stanford Study design study drug suppressed susceptibility tested the median threshold Trial variant Viral Viral load was performed [DOI] 10.1016/j.jcv.2018.02.003 PMC 바로가기 [Article Type] Article
Tenofovir alafenamide demonstrates broad cross-genotype activity against wild-type HBV clinical isolates and maintains susceptibility to drug-resistant HBV isolates in vitroArticle Published on 2017-03-012023-06-16 Journal: Antiviral Research [Category] B형 간염, [키워드] drug susceptibility HBV genotype HBV resistance tenofovir alafenamide (TAF) [DOI] 10.1016/j.antiviral.2016.12.012
Salmonella species in piglets and weaners from Uganda: Prevalence, antimicrobial resistance and herd-level risk factors우간다의 새끼 돼지와 이유 돼지에서의 살모넬라 종: 유병률, 항균제 내성 및 농장 수준의 위험 요인journal-article Published on 2014-07-012024-07-30 Journal: Preventive Veterinary Medicine [Category] 살모넬라증, [키워드] Diversity drug susceptibility Non-typhi Protective factors. [DOI] 10.1016/j.prevetmed.2014.03.009 [Article Type] journal-article
SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatusSREBP는 인간 곰팡이 병원체 Aspergillus fumigatus에서 트리아졸 약물 및 저산소증 반응을 중재하기 위해 철과 에르고스테롤 항상성을 조정합니다Research Article Published on 2011-12-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] A. fumigatus acquisition activated adaptation Adding addition advance Aspergillus fumigatus Author binding Candida albican Candida albicans caused cellular response class clinically condition conditions Coordinate Critical Cryptococcus neoforman Cryptococcus neoformans decrease dependent on drug drug susceptibility drugs ergosterol eukaryotes found foundation fungal fungal infections fungal pathogen Gene Genetic growth growth defect Health Human hypoxia hypoxic identify immunocompromised condition infections initial involved iron iron homeostasis Iron metabolism led to lethal disease majority mechanism metabolism microenvironment Most patients mRNA mutant mutants pathogenic Pathogens Patient phenotype Protein regulate Regulation regulatory element required response restoration Sterol Support susceptibility susceptible These data transcription factor transcription factors triazole virulence [DOI] 10.1371/journal.pgen.1002374 PMC 바로가기 [Article Type] Research Article