GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8GBPs는 Shigella flexneri의 운동성을 억제하지만, 세균 유비퀴틴 리가제 IpaH9.8에 의해 분해 대상으로 지정됩니다.Article Published on 2017-10-112024-08-21 Journal: Cell Host & Microbe [Category] 세균성이질, [키워드] cell-autonomous immunity E3 ubiquitin ligase effector proteins GBP host-pathogen interaction Innate immunity Ipa9.8 ubiquitin ubiquitin coat [DOI] 10.1016/j.chom.2017.09.007 PMC 바로가기 [Article Type] Article
Comparative Genomics of the Sigatoka Disease Complex on Banana Suggests a Link between Parallel Evolutionary Changes in Pseudocercospora fijiensis and Pseudocercospora eumusae and Increased Virulence on the Banana Host바나나에 대한 Sigatoka 질병 복합체의 비교 유전체학은 Pseudocercospora fijiensis와 Pseudocercospora eumusae의 병렬 진화적 변화와 바나나 숙주의 독성 증가 사이의 연관성을 시사합니다Research Article Published on 2016-08-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition adaptation Analysis analyzed assimilation banana biological process caused cell walls change changes in Comparative Comparative analysis Comparative genomics complementary complex conserved convergent evolution core gene Degradation disease disease control Diversity Dothideomycetes driven by effective effector proteins effectors Evolution evolutionary relationships facilitate facilitated fungi gene count gene families gene family Genes Genome genome architecture genome sequence genomes genomic genomic change Genomics higher efficiency Host host immune system identify increase in Increased indicated involved LTR management metabolic pathway metabolic pathways metabolism Modification pathogen pathogenic Pathogens plant cell profile proliferation Radiation remained sequenced Seven significant difference significant differences speciation Still supported understanding utilization virulence virulent [DOI] 10.1371/journal.pgen.1005904 PMC 바로가기 [Article Type] Research Article
Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity비복제 Toxoplasma gondii Uracil Auxotrophs에 의한 Rhoptry 및 Dense Granule Effector 단백질의 분비는 항종양 면역의 발달을 제어합니다Research Article Published on 2016-07-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogated activate activated acute infection Auxotroph auxotrophic mutants axis CD4 CD8 Cell Nucleus Cell signaling cellular signaling pathway cellular signaling pathways conjunction Control deleted Deletion dendritic cells Dense development effective effective therapy effector effector molecule effector molecules effector protein effector proteins function Granule GTPase GTPases Host host cell host cell nucleus host cell response Host immune response host immune responses host innate immunity host response host responses identify IFN-γ immune responses Immune suppression Immunity independent Infection interferon Invasion latent infection mammalian cell mechanism membrane mice mutant not affect nucleus ovarian cancer parasite pathway Pathways Protein required responses rhoptry Safe secreted secretion shown Signaling solid tumor solid tumors survival T cell T cells target therapeutic These data Toxoplasma gondii transcriptional Trigger Tumor tumor microenvironment tumors type I uracil vaccination vaccine strain virulence [DOI] 10.1371/journal.pgen.1006189 PMC 바로가기 [Article Type] Research Article