Comparative performance data for multiplex SARS-CoV-2 serological assays from a large panel of dried blood spot specimensResearch article Published on 2022-08-282022-10-05 Journal: Heliyon [Category] 유전자 메커니즘, [키워드] Anti-spike Antibody titers assays binding domain Bio-rad Blood Canada collected Comparative convalescent COVID-19 patient COVID-19 COVID-19 pandemic DBS sample Direct Dried blood spots Elecsy evaluated IgG immunoassays individual Infection Mount Sinai MSD multiple antigen multiplex observé Panel protocols RBD resulting Roche SARS-CoV-2 SARS-CoV-2 antibody testing SARS-CoV-2 IgG sensitivity Serological assay serology Serosurvey Serosurveys specificity specimen transmitted university [DOI] 10.1016/j.heliyon.2022.e10270 [Article Type] Research article
Correlation between In Vitro Neutralization Assay and Serological Tests for Protective Antibodies DetectionArticle Published on 2022-08-242022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, 치료기술, [키워드] 2019-nCoV Accuracy alternative method analyses antibodies assays Biosafety Level 3 coefficients correlation detection diagnostics Elecsy ELISA Epidemiological study Epidemiology Euroimmun gold standard highest humoral Humoral immunity IgG immunoassay individual Kappa coefficient Linear regression neutralizing antibody operators outcome Pearson performed plaque reduction neutralization plaque reduction neutralization test (PRNT) positive Predictive PRNT Protective antibody protective immunity reference method ROC ROC Curve Roche S-RBD SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S sensitivity serological serological test serum samples Spearman Spearman coefficient specificity Spread surrogate virus neutralization test (sVNT). sVNT Test virus neutralization test [DOI] 10.3390/ijms23179566 PMC 바로가기
Antibody Response in Immunocompromised Patients After the Administration of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine BNT162b2 or mRNA-1273: A Randomized Controlled Trial중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2) 백신 BNT162b2 또는 mRNA-1273 투여 후 면역저하 환자의 항체 반응: 무작위 대조 시험Randomized Controlled Trial Published on 2022-08-242022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, 진단, [키워드] 1:1 95% confidence interval acute respiratory syndrome addition Antibody Response BNT162b2 Cohort Controlled coronavirus coronavirus 2 Cutoff Efficacy Elecsy first vaccination had no HIV Human immunodeficiency virus immune response immunoassay Immunocompromised patient Immunocompromised patients infections intention-to-treat analysis kidney lung Moderna mRNA-1273 Open-label organ Organ transplant Patient Pfizer-BioNTech platform Platform trial PLWH Prevent primary endpoint proportion Protein Randomized randomized clinical trial Randomized controlled trial Receptor binding domain recipient respiratory response SARS-CoV-2 SARS-CoV-2 spike second vaccination solid organ transplant the antibody response Transplant Vaccine was measured [DOI] 10.1093/cid/ciac169 PMC 바로가기 [Article Type] Randomized Controlled Trial
Development of an in-house quantitative ELISA for the evaluation of different Covid-19 vaccines in humans인간에서 다양한 Covid-19 백신 평가를 위한 사내 정량 ELISA 개발Article Published on 2022-07-042022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] Accuracy anti-RBD antibody approved carried convalescent individual COVID-19 COVID-19 vaccine COVID-19 vaccines development ectodomain Effectiveness Efficacy Efficiency Elecsy ELISA Genscript house Human immune responses in-house ELISA inactivated infected with SARS-CoV-2 mounted mRNA vaccine nucleocapsid Pfizer Pfizer/BioNTech positive Program Protein Quantitative recipient recipients responses Roche RT-PCR SARS-CoV-2 SARS-CoV-2 IgG sensitivity Serological assay serum sample serum samples shown specificity spike the SARS-CoV-2 vaccination Vaccine Vaccines virus [DOI] 10.1038/s41598-022-15378-1 PMC 바로가기 [Article Type] Article
Prognostic Utility of Procalcitonin, Presepsin, and the VACO Index for Predicting 30-day Mortality in Hospitalized COVID-19 Patients입원한 COVID-19 환자의 30일 사망률을 예측하기 위한 Procalcitonin, Presepsin 및 VACO 지수의 예후 유용성Article Published on 2022-07-012022-09-11 Journal: Annals of laboratory medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] 30-Day mortality 95% confidence interval addition age Analysis Biomarker Biomarkers calculated Clinical outcome clinical outcomes Comorbidities coronavirus coronavirus disease COVID-19 COVID-19 patients cut-off value demonstrated Elecsy enrolled Germany hazard ratio hazard ratios health administration hospitalized COVID-19 patient index investigated Japan Kaplan-Meier method Kaplan-Meier survival analysis Kobe Mortality Patient PCT predict prediction Presepsin procalcitonin prognostic Prognostic value ROC Curve Roche Diagnostics Sex significantly survival analysis utility VACO index. veteran was used were measured [DOI] 10.3343/alm.2022.42.4.406 PMC 바로가기 [Article Type] Article
COVID-19 Seroprevalence in ED Health Care Professionals Study: A Cross-Sectional StudyED 의료 전문가 연구의 COVID-19 혈청 유병률: 횡단면 연구Article Published on 2022-07-012022-09-12 Journal: Journal of emergency nursing [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI antibody Antibody test Asymptomatic blood draw blood sample Care clinician COVID-19 COVID-19 antibody COVID-19 infection COVID-19 seroprevalence cross-sectional design Elecsy eligible Health increased risk initial management Nurses outbreak participant Patient patients Physicians professional professionals questionnaire Roche Sample SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 seroprevalence seropositive Seroprevalence study period the SARS-CoV-2 [DOI] 10.1016/j.jen.2022.04.003 PMC 바로가기 [Article Type] Article
Convalescent plasma donors show enhanced cross-reactive neutralizing antibody response to antigenic variants of SARS-CoV-2 following immunization회복기 혈장 기증자는 예방 접종 후 SARS-CoV-2의 항원 변이체에 대한 향상된 교차 반응성 중화 항체 반응을 보여줍니다Article Published on 2022-07-012022-09-11 Journal: Transfusion [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Alpha anti-SARS-CoV-2 anti-spike antibody antibody Antibody neutralization antigenic antigenic variant antigenic variants antigenic variation automated Beta circulating convalescent convalescent plasma COVID-19 cross-reactive Delta determined by Donor dose Effect Elecsy focus geometric mean geometric mean titer GMT GMTs immunization infected with SARS-CoV-2 Live virus microneutralization NAb NAb titers NAbs neutralization neutralization potency neutralization test neutralize Neutralizing antibodies neutralizing antibody Neutralizing antibody response omicron Pfizer plasma Predictive prototype Quantitative reactivity reduction ROC analysis Roche Sample SARS-CoV-2 SARS-CoV-2 strain specificity strain Strains Therapeutic benefit therapy titers treat vaccination Vaccinations vaccine dose Zeneca [DOI] 10.1111/trf.16934 PMC 바로가기 [Article Type] Article
Comparison of extraction-based and elution-based polymerase chain reaction testing, and automated and rapid antigen testing for the diagnosis of severe acute respiratory syndrome coronavirus 2중증급성호흡기증후군 코로나바이러스 2 진단을 위한 추출기반 및 용출기반 중합효소연쇄반응검사와 자동화 및 신속항원검사의 비교Article Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification amplified Antigen antigen detection applied assays automated Chain Reaction clinical sample clinical samples Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Diagnosis diagnostic diagnostic test Dilution dilutions disease Elecsy Elecsys elution extraction Fuji Inc. Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples Novel coronavirus novel coronavirus disease novel coronavirus disease 2019 (COVID-19) Patient PCR PCR assay PCR test performed polymerase chain polymerase chain reaction positive Rapid diagnostic test RDT remained RNA RNA extraction Roche Diagnostics SARS-CoV SARS-CoV-2 SARS-CoV-2 antigen Science severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) System Takara Takara Bio virus [DOI] 10.1002/jmv.27709 PMC 바로가기 [Article Type] Article
Evaluation of the Roche SARS-CoV-2 Rapid Antibody Test in Samples from Vaccinated Individuals예방 접종을 받은 개인의 검체에서 Roche SARS-CoV-2 Rapid Antibody Test의 평가Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] 95% CI 95% confidence interval agreement anti-S antibody antibodies antibody Antibody test Antibody titer Antibody titers BNT162b2 correlated correlation COVID-19 COVID-19 vaccines determine dose Elecsy Elecsys evaluator first dose IgG IgG and IgM immune response Immunity immunoassay individual intensity Moderna mRNA mRNA-1273 natural infection Neutralizing nucleocapsid nucleocapsid protein Pfizer Pfizer-BioNTech point-of-care point-of-care systems postvaccination Quality control Quantitative ranged Rapid rapid antibody test response to vaccination Roche Sample SARS-CoV-2 SARS-COV-2 infection second dose serologic serologic assays serum sample serum samples speed Spike protein stratified Support symptomatic SARS-CoV-2 infection Test the SARS-CoV-2 vaccinated individuals vaccination Vaccines was measured [DOI] 10.1128/spectrum.02709-21 PMC 바로가기 [Article Type] Article
The influence of time on the sensitivity of SARS-CoV-2 serological testingSARS-CoV-2 혈청 검사의 민감도에 대한 시간의 영향Article Published on 2022-06-222022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] 95% CI Abbott anti-SARS-CoV-2 antibodies Antibody titer Antibody titers approach assays best booster vaccination collected Course days post infection demonstrated detect detectable diagnostic diagnostic sensitivity Elecsy evaluated Evidence evidence of follow-up period immune correlate immune correlates infected with SARS-CoV-2 Infection limitation long-lasting median Meso Scale Discovery MSD natural infection Neutralizing no evidence of nucleoprotein occurred Patient performed positive Probability proportion provide Quantitative Roche SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody sensitive sensitivity serological test Serological testing Serological tests shown spike Spike protein Support survival survival time symptom onset the spike protein therapy time-to-event analysis Treatment [DOI] 10.1038/s41598-022-14351-2 PMC 바로가기 [Article Type] Article