Embryonic Origins of Virus-Induced Hearing Loss: Overview of Molecular EtiologyReview Published on 2021-01-062024-09-02 Journal: Viruses [Category] 대상포진, [키워드] auditory system development embryogenesis hearing loss inner ear formation viruses [DOI] 10.3390/v13010071 PMC 바로가기 [Article Type] Review
Neprilysin expression and functions in development, ageing and disease발달, 노화 및 질병에서의 네프릴리신 발현 및 기능Review Published on 2020-12-012022-08-31 Journal: Mechanisms of ageing and development [Category] MERS, SARS, 바이오마커, [키워드] Ageing AICD Alzheimer's disease Alzheimer’s disease amyloid-degrading enzyme angiotensin angiotensin receptor blocker approved Aβ peptide brain development CALLA Cancer CD10 cell proliferation changes in cognitive cognitive behaviour Compound cortex COVID-19 pathogenesis diabetes disease EGCG embryogenesis endopeptidase endopeptidase 24.11 enkephalinase enzyme Epigenetic epigenetic regulation expression foetal development function functions green tea HDACs heart failure hippocampus hypertension hypoxia immune response implicated inhibitor Intensive kidney membrane-bound memory NEP inhibitors olfactory bulbs neprilysin obesity olfactory Organisms Pathogenesis pathological conditions Pathologies peptide pharmacological treatment pharmacological treatments physiological functions prenatal prenatal hypoxia Prevent Preventive medicine Prostate cancer proteolytic receptor blocker Regulation Research Sacubitril striatum striatum. substrate substrates suggested therapeutic target Treatment type-2 diabetes upregulating valsartan [DOI] 10.1016/j.mad.2020.111363 PMC 바로가기 [Article Type] Review
Loss of Xist RNA from the inactive X during B cell development is restored in a dynamic YY1-dependent two-step process in activated B cellsB 세포 발달 동안 비활성 X에서 Xist RNA의 손실은 활성화된 B 세포에서 동적 YY1 종속 2단계 과정으로 복원됩니다.Research Article Published on 2017-10-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Activation adulthood Autoimmune disorders Autoimmunity B cell B cells Cell change chromatin chromosome compensated Critical develop DNA DNA binding domain dosage ectopic expression embryogenesis Epigenetic Ex vivo expression female Genes Genetic heterochromatin Immunity impair inactivation inactive indicate lack Lineage Loss lymphocyte Lymphocytes mechanism Modification modifications pathogenic pattern Recombination regulate regulated restored reveal RNA Stimulation susceptibility transcription factor up-regulation X-linked X-linked gene YY1 Zinc [DOI] 10.1371/journal.pgen.1007050 PMC 바로가기 [Article Type] Research Article
A Dual Role for SOX10 in the Maintenance of the Postnatal Melanocyte Lineage and the Differentiation of Melanocyte Stem Cell Progenitors출생 후 멜라닌 세포 계통의 유지와 멜라닌 세포 줄기 세포 전구체의 분화에서 SOX10의 이중 역할Research Article Published on 2013-07-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adult stem cells appear Author cause Cell cell fate cell type Critical differentiation downregulated downstream driving embryogenesis exacerbate examined Express expression Factor growth hair hair follicle haploinsufficiency idea in vivo increased expression leads Lineage maintain maintenance mechanism Melanocyte melanocytes melanogenesis MITF mitigate Mouse models negative regulation observation overexpression pigment portion precursor Premature prevented progenitor raise regulated Regulation Regulatory role Sox10 STEM stem cell stem cells survival sustained target Transcription transcription factor transcription factors [DOI] 10.1371/journal.pgen.1003644 PMC 바로가기 [Article Type] Research Article
The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6 , a Gene Identified through Mining the DPH1 – DPH5 Interaction Network효모에서 디프타마이드 생합성의 아미드화 단계에는 DPH1 - DPH5 상호작용 네트워크 마이닝을 통해 확인된 유전자인 DPH6이 필요합니다Research Article Published on 2013-02-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate Accuracy adenine adenine nucleotide ADP Affect agent amidase Amino acid approach association ATP Author bind Biosynthesis biosynthetic biosynthetic pathway candidate candidate gene Cell cell growth characterized check Complete completion component components Corynebacterium diphtheriae defined Diphthamide dissociation domain DPH1 Dph5 Dph6 Dph7 eEF2 elongation factor embryogenesis enzyme evade expected failure Final form found generate Genes Genetic genetic interaction genomic growth histidine Identified identify inactivation indicated inhibitor inhibitors initial Interaction involved Like maintain mass spectrometry mice molecular mutant name network nucleotide observation pathogen pathway produced promote Protein protein synthesis Proteins Regulatory required residue response Saccharomyces cerevisiae step target trait translation translational upregulated [DOI] 10.1371/journal.pgen.1003334 PMC 바로가기 [Article Type] Research Article