Biological and Immune Responses to Current Anti-SARS-CoV-2 mRNA Vaccines beyond Anti-Spike Antibody ProductionAnti-Spike 항체 생산을 넘어 현재의 Anti-SARS-CoV-2 mRNA 백신에 대한 생물학적 및 면역 반응Review Published on 2022-05-142022-09-11 Journal: Journal of Immunology Research [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] administration anti-SARS-CoV-2 vaccines anti-spike antibodies antibodies antibody waning antiviral antibodies appear Biological booster carried Cell clinical observation coding current disease distribution effective Efficiency emergence encapsulation Express Factor help immune system Infection injected intramuscularly lack mass vaccination memory B cell memory B cells mRNA not limited oral mucosa pandemic plasma membrane Production PROTECT Protein response RNA molecules RNA virus SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 spike protein spike Spike protein the SARS-CoV-2 the Spike tissue vaccination Vaccine Viral viral variant Viral variants virtue [DOI] 10.1155/2022/4028577 PMC 바로가기 [Article Type] Review
Airway Delivery of Hydrogel-Encapsulated Niclosamide for the Treatment of Inflammatory Airway DiseaseArticle Published on 2022-01-192022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, [키워드] activated administration Affect airway airway epithelial cell airway epithelium anthelminthic applied Asthma asthmatic Calu-3 cells chronic obstructive circumvent CLCA1 clearance comparable Compound COVID-19 delivery disease drugs Effect effective encapsulation Ex vivo examined explained fibrosis glycol human airway epithelial hydrospheres in vitro in vivo Inflammatory inflammatory airway disease Influenza inhibit inhibited inhibitory effect intratracheal instillation Local mice Nanospheres niclosamide pro-inflammatory problems proinflammatory pulmonary disease repurposing respiratory syncytial virus SARS-CoV-2 secretion Side effects TMEM16A TMEM16F Trachea tracheas Treatment viral respiratory infections were assessed while [DOI] 10.3390/ijms23031085 PMC 바로가기 [Article Type] Article
A Dispersion Corrected DFT Investigation of the Inclusion Complexation of Dexamethasone with β-Cyclodextrin and Molecular Docking Study of Its Potential Activity against COVID-19β-Cyclodextrin과 Dexamethasone의 포함 복합체에 대한 분산 수정 DFT 조사 및 COVID-19에 대한 잠재적 활성에 대한 분자 도킹 연구Article Published on 2021-12-152022-09-10 Journal: Molecules [Category] SARS, 치료제, [키워드] β-cyclodextrin 6LU7 active site active sites activity approach AutoDock AutoDock vina binding Bioavailability calculated Cavity characterization complex complexation computation COVID-19 Density functional theory Dexamethasone DFT-D4 dispersion encapsulation ENhance free energy functional hydrogen Hydrogen bond hydrogen bonds inhibitor inhibitory activity Interaction investigated investigation molecular docking Molecular docking study non-covalent interactions PDB PDB ID PDB ID: 6LU7 Potential predicted protease Protease inhibitor Protein reducing SARS CoV-2 Side effects significantly target protein therapeutic activity van der Waal van der Waals interactions was performed [DOI] 10.3390/molecules26247622 PMC 바로가기 [Article Type] Article
Successful Treatment of Acute Myeloid Leukemia with CPX-351 in 2 Patients in the United Kingdom during the COVID-19 PandemicConference abstract Published on 2021-11-232022-10-05 Journal: Blood [Category] 치료법, [키워드] Administered AML appropriate patient approved Asymptomatic benefit blood count Bone marrow change Chemotherapy Comorbidity Complete complications consolidation COVID-19 COVID-19 infection COVID-19 pandemic CPX-351 curative intent Day declined demonstrated Diabetic diagnosed disease download drug history eligible encapsulation Europe fatigue female figure FLT3 group hemoglobin IDH2 Immunocompromised patients Immunosuppression Infection infection rate Intensive IV infusion Jazz male mutated Mutation myeloid myelosuppression nephropathy neutropenic sepsis neutrophil neutrophil count NPM1 occurred pandemic Patient PCR swab Pediatric patient Platelet positive receiving remained risk risk factor Sepsis significantly speaker SRSF2 Symptom synergistic the disease the patient The United States Tolerability treated Treatment Two patient type 2 diabetes United Kingdom White blood cell wild-type working [DOI] 10.1182/blood-2021-146524 [Article Type] Conference abstract
Polymer-Based Nanosystems—A Versatile Delivery ApproachReview Published on 2021-11-112022-10-30 Journal: Materials [Category] COVID-19, [키워드] carrier Concentration Degradation delivery drug clearance drug delivery drugs encapsulation Genes immunomodulatory property inherent linear morphology novel nanocarriers Polymer polymer-based nanoparticles raised reduce stability sustained Targeted delivery Vaccine Vaccine adjuvants vaccine delivery Vaccine development [DOI] 10.3390/ma14226812 PMC 바로가기 [Article Type] Review
Jeopardy of COVID-19: Rechecking the Perks of Phytotherapeutic InterventionsCovid-19의 위태로움 : 식물성 요법의 특전 재발Review Published on 2021-11-102022-08-31 Journal: Molecules [Category] MERS, SARS, 신약개발, [키워드] acute kidney angiotensin angiotensin converting enzyme Angiotensin converting enzyme-2 anti-inflammatory activity antioxidant antiviral activities antiviral activity attachment can be used chemical structures clinical complication clinical status Combination Complication coronavirus disease country COVID-19 deteriorate disease Diseases drug effective encapsulation environmental stress focus Health Health crisis help Immunity implication IMPROVE increase in infected patients Inflammation inhibit Kidney disease knowledge lack Liver disease medicinal plants metabolite neurological Novel coronavirus novel coronavirus disease nutrition oxidative stress pharmacological phytotherapy plant plants Prophylactic protease provide reason reason for Replication respiratory SARS-CoV-2 Serine Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Side effect signaling molecule signaling molecules spike glycoprotein structures therapeutic transmembrane serine protease transmembrane serine protease 2 unique virus viruses worldwide pandemic [DOI] 10.3390/molecules26226783 PMC 바로가기 [Article Type] Review
DNA‐Directed Patterning for Versatile Validation and Characterization of a Lipid‐Based Nanoparticle Model of SARS‐CoV‐2SARS -COV -2의 지질 기반 나노 입자 모델의 다목적 검증 및 특성화를위한 DNA 방향 패터닝Research Article Published on 2021-10-212022-08-31 Journal: Advanced Science [Category] MERS, SARS, 변종, 진단, 치료제, [키워드] a glass ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin applied assays benefit bind binding biological function CD63 Cell characterization complementary oligonucleotide complementary oligonucleotides coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 demonstrated DNA‐directed patterning Efficacy encapsulation enzyme flexible glass hybridized Liposome liposomes mixture Model nanoparticle Neutralizing antibodies neutralizing antibody offer oligonucleotide oligonucleotides Population power Precision Protein Region respiratory SARS‐CoV‐2 SARS‐CoV‐2 spike SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus spike subsequent substrate surface proteins Vaccine validation variants variety virus [DOI] 10.1002/advs.202101166 PMC 바로가기 [Article Type] Research Article
Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunityResearch Article Published on 2021-10-012022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, SARS, [키워드] ACE2, angiotensin-converting enzyme II adverse effect antibody approach BCA, bicinchoninic acid BLI, bioluminescent imaging can be used Cationic lipid CDM, chemically defined media Cell cellular characterized COVID19 CTCS, clarified tissue culture supernatant CVS, concentrated vesicle suspension DOPE, dioleoyl phosphatidylethanolamine dose DOTAP, dioleoyl-3-trimethylammonium propane DTZ, diphenylterazine elicited encapsulation ER, endoplasmic reticulum EV, extracellular vesicle Evidence Exosome Exosomes Extracellular vesicles form functional had no human cell Humoral response HUVEC, human umbilical vein endothelial cell immunogenic induce injection Lipid nanoparticle lipofection LNP LNP, Lipid Nanoparticle long-lasting luciferase expression mice mRNA NTA, nanoparticle tracking analysis nucleocapsid ORF, open reading frame pfPBS, particle-free PBS previous study Protein repeated responses Safe SARS-CoV-2 immunity SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SEC, size-exclusion chromatography Skeletal muscle spike sustained T-cell tested the SARS-CoV-2 tissue Toxicity vitreous fluid [DOI] 10.1016/j.jbc.2021.101266 PMC 바로가기 [Article Type] Research Article
Fluoxetine hydrochloride loaded lipid polymer hybrid nanoparticles showed possible efficiency against SARS-CoV-2 infectionFluoxetine hydrochloride가 탑재된 지질 고분자 하이브리드 나노 입자는 SARS-CoV-2 감염에 대해 가능한 효율성을 보여주었습니다Article Published on 2021-09-252022-09-11 Journal: International journal of pharmaceutics [Category] SARS, 신약개발, [키워드] acute respiratory syndrome coronavirus Affect Anti-inflammatory anticoagulant effects antidepressant Antiviral approach approved drug binding energy cells cellular coronavirus COVID 19 COVID-19 COVID-19 pandemic disease drug Drug repurposing drugs Economy Efficiency encapsulation ENhance fibroblast Fluoxetine Fluoxetine hydrochloride global health Health Human hydrogen Hydrogen bond Interaction Lipid Lipid polymer hybrid lung management molecular docking molecular docking studies Molecular docking study optimization Paroxetine performed Polymer predict protease repurposing respiratory SARS-COV-2 infection SARS-CoV-2 main protease selective Serotonin serotonin reuptake inhibitor severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 SSRIs. suggested therapeutic activity Treatment zeta potential [DOI] 10.1016/j.ijpharm.2021.121023 PMC 바로가기 [Article Type] Article
Development of an mRNA-LNP Vaccine against SARS-CoV-2: Evaluation of Immune Response in Mouse and Rhesus MacaqueArticle Published on 2021-09-102022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] approaches C57BL/6 CAP Characteristics cytotoxicity demonstrated development Efficacy ELISA ELISA assay encapsulation evaluated feature IFN-γ IL-4 immune response immunized mice in vitro in vitro transcription infused injected injection introduced Lipid nanoparticle Liposome LNP macaque marker mice Moderna mouse mRNA mRNA vaccine mRNA-based mRNA-vaccine Neutralizing neutralizing antibody nucleoside analog Pfizer/BioNTech produced response rhesus SARS-CoV-2 secretion Spike protein stability the vaccine Vaccine virus VNT [DOI] 10.3390/vaccines9091007 PMC 바로가기 [Article Type] Article