Comparing COVID-19-related hospitalization rates among individuals with infection-induced and vaccine-induced immunity in Israel이스라엘의 감염 유도 면역과 백신 유도 면역이 있는 개인의 COVID-19 관련 입원율 비교Article Published on 2022-04-222022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] adjusted BNT162b2 booster booster vaccination confounders COVID-19 COVID-19 pandemic COVID-19 vaccine Critical delta variant dose doses Effectiveness ENhance enhancer FIVE Hospitalization Immunity incidence rate individual less population immunity predominant provide reduced subsequent vaccine dose vaccine immunity Vaccine-induced immunity were assessed [DOI] 10.1038/s41467-022-29858-5 PMC 바로가기 [Article Type] Article
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19코비드-19를 가진 고위험, 입원하지 않은 성인을 위한 경구 NirmatrelvirClinical Trial Published on 2022-04-142022-09-11 Journal: The New England Journal of Medicine [Category] COVID19(2023년), SARS, 신약개발, 임상, 진단, 치료제, [키워드] 1:1 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus adjusted Administered adverse event adverse events Analysis assigned conducted Controlled trial coronavirus coronavirus disease Coronavirus disease 2019 death deaths diarrhea double-blind drug dysgeusia enhancer evaluated Final final analysis high risk Hospitalization in vitro incidence inhibitor initiated interim analysis log M pro mean difference milliliter modified intention-to treat modified intention-to-treat Nirmatrelvir occurred onset of symptoms oral Patient patients patients treated Pfizer pharmacokinetic Placebo placebo group progression protease randomization randomized, controlled trial receive Relative risk risk risk reduction Ritonavir Serious Adverse Events severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 symptom onset symptomatic symptomatic COVID-19 the placebo group Treatment treatment period two group two groups Viral load [DOI] 10.1056/NEJMoa2118542 PMC 바로가기 [Article Type] Clinical Trial
Management of drug-drug interactions with nirmatrelvir/ritonavir in patients treated for Covid-19: Guidelines from the French Society of Pharmacology and Therapeutics (SFPT)Research article Published on 2022-04-012022-10-05 Journal: Thérapie [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome Adverse drug reaction Antiviral association clinician Combination complex Contact coronavirus Course cysteine protease draft drug drug monitoring drug-drug interaction Efficacy enhancer enzyme Final French guideline help high risk management Modification modifications MPro National Nirmatrelvir objective Participants patients treated Paxlovid Pfizer Pharmacodynamics pharmacokinetic pharmacokinetics Pharmacology Pragmatic Prevent primary care protease recommendation recommendations Result Ritonavir SARS-CoV-2 secure Society therapeutic therapeutic strategy Therapeutics Treatment [DOI] 10.1016/j.therap.2022.03.005 [Article Type] Research article
Spread of hypervirulent multidrug-resistant ST147 Klebsiella pneumoniae in patients with severe COVID-19: an observational study from Italy, 2020-21Observational Study Published on 2022-03-312022-10-05 Journal: Journal of Antimicrobial Chemotherapy [Category] Coronavirus, 임상, [키워드] Bloodstream infections capsular carried chromosome clinical collected Combination Complete COVID-19 COVID-19 patient COVID-19 patients Diagnosis enhancer ESBL genes encoding high mortality Illumina Miseq Infection infection control isolate Italy Klebsiella pneumoniae majority measure Mortality multidrug-resistant outbreak outcome Patient phenotype Plasmid Prospective rectal reported resistance genes Sequencing strain string test Surveillance susceptibility treated university urinary tract infections Urine Ventilator-associated pneumonia was determined was performed whole genome [DOI] 10.1093/jac/dkab495 PMC 바로가기 [Article Type] Observational Study
Reproductive and developmental safety of nirmatrelvir (PF-07321332), an oral SARS-CoV-2 M pro inhibitor in animal models동물 모델에서 경구용 SARS-CoV-2 M pro 억제제인 니르마트렐비르(PF-07321332)의 생식 및 발달 안전성Article Published on 2022-03-012022-09-11 Journal: Reproductive toxicology (Elmsford, N.Y.) [Category] 치료제, [키워드] administration age animal model Antiviral Clinical studies clinical study clinically coronavirus COVID-19 Critical death developmental during pregnancy Effect Embryo Embryo-Fetal development embryonic embryonic development enhancer evaluated Factor female female fertility Fertility Genetic Genetic toxicity high risk Hospitalization hospitalized patient ICH in viral infected with SARS-CoV-2 information inhibitor lack limit dose M pro male mammalian cells manifestation Nirmatrelvir NMV no effect no effects oral Oral COVID-19 therapy patient population Paxlovid PF-07321332 pharmacokinetic phase Pregnancy Prevent progression protease Protein rabbit RAT Rat. RATs Replication reported reproductive risk Ritonavir SARS-CoV-2 SARS-CoV-2 main protease selective severe disease shown specific protein the SARS-CoV-2 therapeutic option therapeutic target therapy Toxicity viral replication virus [DOI] 10.1016/j.reprotox.2022.01.006 PMC 바로가기 [Article Type] Article
Super interactive promoters provide insight into cell type-specific regulatory networks in blood lineage cell types슈퍼 대화식 프로모터는 혈액 계통 세포 유형에서 세포 유형-특이 적 조절 네트워크에 대한 통찰력을 제공Research Article Published on 2022-01-312022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] analysis Analysis ATAC-seq binding Blood blood cell Blood cells capture CD4 Cell cell type cell types chromatin compendium complex Critical disrupt driven by enhancer enhancers EPHB3 ETS1 explain Express expression level FIVE Follow-up functional Genetic variant GWAS GWAS variant GWAS variants help hematological hypothese identify implication include independent Interaction interactions interactivity Interpretation Lineage locus lymphocyte Lymphocyte count motifs norm overlap Phenotypes PIR Platelet Platelet count promoter promoters provide redundancy Region regions Regulatory regulatory network regulatory region resource strong interactions traits transcription factor transcriptional transcriptional regulation variant variants [DOI] 10.1371/journal.pgen.1009984 PMC 바로가기 [Article Type] Research Article
Ezrin Peptide Therapy from HIV to COVID: Inhibition of Inflammation and Amplification of Adaptive Anti-Viral ImmunityHIV에서 COVID로의 Ezrin Peptide Therapy: 염증 억제 및 적응형 항바이러스 면역의 증폭Review Published on 2021-10-282022-09-10 Journal: International Journal of Molecular Sciences [Category] 치료제, [키워드] accompanied activate adaptive adjuvant adjuvants Administered amino acids Anti-viral immunity antibody antibody titres B cell candidiasis chronic diarrhea Clinical studies clinical study Colon COVID Cytokines derivative diarrhea disappearance disease domain duodenum dysregulation effective ENhance enhancer enhancers Enterocolitis expression ezrin ezrin peptides FIVE gp120 HCV herpes herpes zoster HIV HIV-infected patients homologous HPV Human human respiratory viruses IL-6 immune responses Immunity Inflammation inflammatory complications Inflammatory cytokines Influenza Inhaled inhibition inhibitor inhibitors innate immune response innate immune responses mice Microbiome middle Mild-to-moderate mucosal Mutation normalization opportunistic infection opportunistic Infections outbreak peptide peptides Placebo Prevent produced Protein randomised receptor Registered replicated respiratory respiratory viruses resulting Russia SARS-CoV-2 SARS-COV-2 infection shown stomach synthetic synthetic peptides T cell therapy tissue repair treat Treatment ulceration vaccination Viral viral respiratory virus virus infection viruses Volunteer [DOI] 10.3390/ijms222111688 PMC 바로가기 [Article Type] Review
A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19CTCF 결합을 방해하는 인터루킨-6의 저생산 일배체형은 심각한 COVID-19를 예방합니다Research Article Published on 2021-10-122022-09-10 Journal: mBio [Category] MERS, 변종, [키워드] 95% confidence interval allele Analysis antisense Asia Asian bidirectional transcription carrier carriers Chinese conserved correlated COVID-19 COVID-19 patient COVID-19 severity CTCF defined Disease progression disturbance element Endemic enhancer expression functional genetic polymorphisms Genotype Haplotype Human humans hyperinflammation IL-6 IL-6 blockade IL-6 expression induce Inflammatory responses inflammatory stimuli interleukin-6 intronic SNP intronic SNPs loci locus long noncoding RNA lower risk Mild Neanderthal Odds ratio outcome patients polymorphism Polymorphisms promoter Protective Quantitative reduced severe symptom severe symptoms severity significantly single-nucleotide Single-nucleotide polymorphisms SNP SNPs T allele therapy transcribed Variability variant Viral viral infection with COVID-19 [DOI] 10.1128/mBio.01372-21 PMC 바로가기 [Article Type] Research Article
A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptomeSARS-CoV-2 트랜스라톰 및 트랜스크립톰의 고해상도 시간 지도Article Published on 2021-08-252022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caused coronavirus COVID-19 deaths downstream enhancer evaluate function genomic help High-resolution human cells Human genome identify infecting initiate leader sequence mRNA ORF ORFs provide regulated Regulation respiratory resulting SARS-CoV-2 Sequencing severe acute respiratory syndrome Coronavirus sRNA subgenomic RNA subgenomic RNAs suppressor the SARS-CoV-2 Transcriptome translation translation initiation unique [DOI] 10.1038/s41467-021-25361-5 PMC 바로가기 [Article Type] Article
A Review on the Development of Gold and Silver Nanoparticles-Based Biosensor as a Detection Strategy of Emerging and Pathogenic RNA Virus신흥 및 병원성 RNA 바이러스의 탐지 전략으로 금 및은 나노 입자 기반 바이오 센서의 개발에 대한 검토Review Published on 2021-07-282022-09-10 Journal: Sensors (Basel, Switzerland) [Category] SARS, 치료기술, 치료제, [키워드] Accuracy addition analytical methods antibody Antigen biological activity biosensor Characteristics clinical samples Containment contribute death detection detection system development disease Diseases DNA early diagnosis effective electrochemical biosensing enhancer gold higher risk highly pathogenic human coronaviruses immunological involved knowledge MERS-CoV Nanoparticles nanotechnologies Nanotechnology nucleic acid optical pathogenic plasmonic POC point-of-care probe Protein provide required review RNA RNA viruses robust SARS-CoV SARS-CoV-2 Sensitivity and specificity severe cases silver single-stranded DNA ssDNA Strategy Treatment unique Viral viral disease Viral diseases viral infection viral nucleic acid virtue viruses [DOI] 10.3390/s21155114 PMC 바로가기 [Article Type] Review