Comparative Characterization and Pathogenicity of a Novel Porcine Epidemic Diarrhea Virus (PEDV) with a Naturally Occurring Truncated ORF3 Gene Coinfected with PEDVs Possessing an Intact ORF3 Gene in PigletsArticle Published on 2021-08-072022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] 3′UTR caused characterization China Clinical sign Coinfection Comparative Complete demonstrated diarrhea disease enterocytes epidemic diarrhea exhibited genetic marker Genotype genotypes highest hpi identity inoculated Intact molecular characteristics mortality rate Naturally novel nucleotide ORF3 pathogenicity PEDV Porcine epidemic diarrhea virus Region reported significantly higher strain Vaccine development virulence virus were infected [DOI] 10.3390/v13081562 PMC 바로가기 [Article Type] Article
Differential susceptibility of SARS‐CoV‐2 in animals: Evidence of ACE2 host receptor distribution in companion animals, livestock and wildlife by immunohistochemical characterisation동물에서 SARS-CoV-2의 감수성: 면역조직화학적 특성화에 의한 반려동물, 가축 및 야생동물에서 ACE2 숙주 수용체 분포의 증거Original Article Published on 2021-07-262022-09-10 Journal: Transboundary and emerging diseases [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] absence ACE2 ACE2 expression Acinonyx addition anatomical angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 binding bronchiolar cats cattle characterisation cheetah coronavirus distribution Enterocyte enterocytes enzyme Eptesicus European badger Evidence evidence of felids Felis ferret ferrets gastrointestinal tracts histological Host host cell host cell membrane host receptor host susceptibility humans IHC immunohistochemistry in some indicated information intestine limit lion Lower respiratory tract lung Lungs Mesocricetus microvillus mink mustelids nasal nasal mucosa nasal turbinate Neovison Ovis primates Protein receptor respiratory respiratory and gastrointestinal tracts respiratory tract respiratory tracts SARS Coronavirus SARS coronaviruses SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 serotine bat sheep species susceptibility tiger tissue tissue tropism Trachea Viral viral infection zoonoses [DOI] 10.1111/tbed.14232 PMC 바로가기 [Article Type] Original Article
Targeting the intestinal TMPRSS2 protease to prevent SARS-CoV-2 entry into enterocytes-prospects and challengesReview Published on 2021-05-222023-07-01 Journal: Molecular biology reports [Category] SARS, [키워드] Drug inhibitor enterocytes SARS-CoV-2 serine protease TMPRSS2 [DOI] 10.1007/s11033-021-06390-1 PMC 바로가기 [Article Type] Review
Diarrhea due to SARS-CoV-2-Related Exocrine Pancreatic InsufficiencyCase Report Published on 2021-05-212022-11-01 Journal: Case Reports in Gastrointestinal Medicine [Category] COVID-19, [키워드] ACE-2 ACE-2 receptor Analysis case sery diarrhea Enterocyte enterocytes entry receptor Exocrine expressed fecal Gastrointestinal infected with SARS-CoV-2 Infection Injury mechanism novel coronavirus SARS-CoV-2 pancreatic Pancreatic Insufficiency Patient patients predominant receptor respiratory symptom responsible resulting SARS-CoV-2 SARS-CoV-2-infected patient Symptoms viral invasion [DOI] 10.1155/2021/9920981 PMC 바로가기 [Article Type] Case Report
Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infectionIFN-γ에 대한 상피 반응은 SARS-CoV-2 감염을 촉진합니다Report Published on 2021-03-032022-09-11 Journal: EMBO Molecular Medicine [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 expression Affect agent angiotensin Antiviral cause cell differentiation cellular cellular differentiation characterized Colon colonic COVID‐19 Culture differentiation disease elevated Enterocyte enterocytes epithelial epithelial cell epithelial cells expressed expressing gastrointestinal mucosa IFN‐γ immune response immune responses immunology induce Inducing inefficient infected cells Infection Inflammation Inflammatory response interferon interferon signaling KRT20 maturation mechanism mediator Microbiology, Virology & Host Pathogen Interaction mouse Organoid organoids outcome patients promote promoted receptor Replication respiratory response robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 Severe case severe cases subset susceptibility susceptibility to infection Treatment virus clearance virus production virus replication virus transmission [DOI] 10.15252/emmm.202013191 PMC 바로가기 [Article Type] Report
SARS-CoV-2 Infection and Disease Modelling Using Stem Cell Technology and Organoids줄기 세포 기술 및 오르가노이드를 사용한 SARS-CoV-2 감염 및 질병 모델링Review Published on 2021-02-262022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, 진단, [키워드] ACE2 airway epithelial cells alveolar Apoptosis cardiovascular system Cell cell damage cells Central nervous system Choroid plexus Clinical studies clinical study colonic contribute demonstrated Direct disease Endothelial cell endothelial cells Enterocyte enterocytes epithelial epithelial cells gastrointestinal tract highlighting human host Hypothesis immunological impairing in vitro model indirect effect indirect effects infect infected individuals Inflammation innate immune response intestinal organoid lung lung alveolar lung epithelia mechanism Neurological symptom Neurological symptoms Neuron neurons Organoid organoids organs Pathogenesis pathogenesis of SARS-CoV-2 replicate review SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 pathogenesis STEM stem cell surfactant susceptible systemic inflammatory target technology Trigger triggers tropism type I variance Vascular damage Viral viral damage viral infection virus [DOI] 10.3390/ijms22052356 PMC 바로가기 [Article Type] Review
SARS-CoV-2 and the Gastrointestinal Tract in ChildrenPediatrics Published on 2021-02-222022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] abdominal pain abundantly expressed ACE-2 acute respiratory syndrome angiotensin-converting enzyme-2 anorexia Appendicitis Atypical Care caused Cell change changes in children Clinical practice coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pandemic diagnostic procedures diarrhea disorder enterocytes explain gastroenterology Gastrointestinal gastrointestinal symptoms Gut Health Service Healthcare provision homeostasis IBD include Inflammation Inflammatory bowel disease intestinal lung cells management manifestation mechanism mimicking mucosal nausea pediatric gastroenterology presenting symptom raised receptor reported Respiratory disease risk Safe SARS-CoV-2 the disease tract vomiting [DOI] 10.3389/fped.2021.617980 PMC 바로가기 [Article Type] Pediatrics
Identification of SARS-CoV-2 inhibitors using lung and colonic organoids폐 및 결장 오르가노이드를 이용한 SARS-CoV-2 억제제 식별Article Published on 2021-01-012022-09-11 Journal: Nature [Category] MERS, SARS, 바이오마커, 신약개발, 진단, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alveolar approved Cell cell types cells chemokine chemokines colonic complementary coronavirus COVID-19 COVID-19 therapeutics Disease model disease models drug Drug administration Drug screening enterocytes Entry inhibitor entry inhibitors Express facilitate FDA food hPSC-derived colonic organoid human disease identification identify Imatinib infect inhibited inhibitor lung Manifestations mycophenolic acid Organoid outcome Patient patients with COVID-19 performed pluripotent stem cell quinacrine respiratory respiratory tract robust SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus significantly stem cells These data US Food and Drug Administration valuable resource [DOI] 10.1038/s41586-020-2901-9 PMC 바로가기 [Article Type] Article
Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2-related Disease장 염증은 ACE2 및 TMPRSS2의 발현을 조절하고 SARS-CoV-2 관련 질병의 발병과 잠재적으로 겹칩니다Article Published on 2021-01-012022-09-11 Journal: Gastroenterology [Category] Fulltext, SARS, 비임상, 임상, 진단, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition biologic bowel breath brush border confluence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection defined drug enterocytes expression Gastrointestinal symptom gastrointestinal symptoms generate GI Tract IBD IBD Medications Inflammation Inflammatory bowel disease Intersection intestinal intestinal inflammation intestines large cohort medications molecular network molecular response molecular responses network Network Analyses. Patient receptor Replication respiratory SARS-CoV-2 significantly Stool Support These data TMPRSS2 Treatment treatment of COVID-19 Viral Viral RNA [DOI] 10.1053/j.gastro.2020.09.029 PMC 바로가기 [Article Type] Article
Postoperative Onset and Detection of SARS-CoV-2 in Surgically Resected Specimens From Gastrointestinal Cancer Patients With Pre/Asymptomatic COVID-19전/무증상 COVID-19가 있는 위장암 환자의 수술로 절제된 표본에서 SARS-CoV-2의 수술 후 발병 및 검출Article Published on 2020-12-012022-09-11 Journal: Annals of surgery [Category] SARS, 치료기술, [키워드] Abnormalities abnormality ACE2 All the patient all the patients analyzed cancer patient Case fatality rate Chest computed tomography clinical Clinical course clinical courses Clinical data collected Computed tomography COVID-19 cytoplasm death detect detection Diagnosis elective surgeries Elective surgery enrolled Enterocyte enterocytes epidemiologic feature Evidence evidence of expression Fatality rate feasibility Gastrointestinal high risk highlight implication Infection Limited Macrophage macrophages male median age much higher natural history Onset pandemic Patient patients with COVID-19 postoperative presenting respiratory respiratory symptom respiratory symptoms SARS-CoV-2 specimen specimens surgery Surgical Procedure symptom onset tissue Treatment treatment of COVID-19 tropism of SARS-CoV-2 [DOI] 10.1097/SLA.0000000000004362 PMC 바로가기 [Article Type] Article