envelope protein – Page 2 – Communicable Diseases Research

Antibodies against the SARS-CoV-2 S1-RBD cross-react with dengue virus and hinder dengue pathogenesis

Article

Published on 2022-08-152022-11-15
Journal: Frontiers in Immunology [Category] SARS, 진단,

Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19

멜라토닌: COVID-19의 급성 후유증에서 바이러스 상 분리 및 Epitranscriptomics의 조절

Review

Published on 2022-07-232022-09-11
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료법,

[키워드] Activation acute infection alteration antiviral immune response blockade change changes Concentration COVID-19 DDX3X depolarization derepression distress early infection ENhance envelope protein Epigenetic Evolution G3BP1 Genome genomic Glycolysis GSK-3 herd immunity Host host cell host genome human host immune immune responses Immunity induce Infection influence LINE1 liquid-liquid phase separation m6A maintain manifestation mechanisms melatonin membrane microenvironment mitochondrial modifications morphology nuclear nucleocapsid outcome oxidative oxidative stress PASC phase Prevent pro-inflammatory cytokine promote PROTECT regulate resulting RNA SARS-CoV-2 virus separation sequestration Signaling signaling cascades significantly Stress stress granule stress granules Support suppress switching the SARS-CoV-2 the SARS-CoV-2 virus Transcription transcriptomic viral genome viral persistence viral replication Viral RNA virus
[DOI] 10.3390/ijms23158122 PMC 바로가기 [Article Type] Review

Virtual repurposing of ursodeoxycholate and chenodeoxycholate as lead candidates against SARS-Cov2-Envelope protein: A molecular dynamics investigation

SARS-Cov2-Envelope 단백질에 대한 주요 후보로 우르소데옥시콜레이트 및 케노데옥시콜레이트의 가상 용도 변경: 분자 역학 조사

Article

Published on 2022-07-012022-09-11
Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 신약개발,

[키워드] absence affected Analysis binding blind candidate caused CDC channel Chenodeoxycholate Comparative complexes computational method Contact COVID-19 disrupting docking DPPC drug Drug repurposing envelope protein evaluate facilitated followed by functional generate group H-bonding H-bonds homologue homology hydrophobic inhibitor membrane molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations molecular interaction monomeric observation polar profile residue SARS-Cov2-E sequence identity Structural properties structural property survival trajectory transmembrane region ursodeoxycholate ursodeoxycholate. viral cell was used water water molecule water molecules
[DOI] 10.1080/07391102.2020.1868339 PMC 바로가기 [Article Type] Article

Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains

인도 SARS-CoV-2 균주의 구조 단백질 관련 유전자를 침묵시키는 효과적인 siRNA의 계산 연구 및 설계

Article

Published on 2022-06-012022-09-11
Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 치료법, 치료제,

[키워드] absence acute respiratory disease Ago2 Algorithm animal models antiviral drug antiviral drugs Antiviral treatment binding candidate collected complementary Consensus COVID-19 deaths docking Effect effective envelope protein feature free energy GC content gene silencing Genes Genome Health Organization heat capacity Human Human genome in vitro in vivo India melting temperature membrane protein molecular docking analysis nucleic acid nucleocapsid nucleotide nucleotides outbreak pandemic parameter pathogenic coronavirus pathway Post-transcriptional gene silencing Protein public health Region reported Respiratory disease RNA RNA interference RNAi SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains selected sequence sequenced siRNA siRNA molecule siRNA molecules siRNAs structural protein structural proteins Surface glycoprotein target target gene target mRNA temperature Therapeutic treatment triggered viral pathogenesis WHO World Health Organization
[DOI] 10.1016/j.compbiolchem.2022.107687 PMC 바로가기 [Article Type] Article

A conserved subunit vaccine designed against SARS-CoV-2 variants showed evidence in neutralizing the virus

SARS-CoV-2 변이체에 대해 설계된 보존 소단위 백신은 바이러스를 중화하는 증거를 보여주었습니다

Article

Published on 2022-06-012022-09-11
Journal: Applied Microbiology and Biotechnology [Category] COVID19(2023년), SARS, 변종, 치료기술,

[키워드] addition affinity analyzed antibody approach B-cell response conserved coronavirus coronavirus disease country Coverage COVID-19 Cytopathic effect docking domain Efficiency elicit envelope envelope protein epitope Epitope-based vaccine Epitopes Evidence FIVE genomes glycoprotein highest IgG immunogenic immunoinformatics IMPROVE induce linker lung tissue membrane membrane glycoprotein MHC MHC class MHC class I MHC class II mice molecular molecular docking Multi-epitope vaccine Mutation neutralize Neutralizing Neutralizing antibodies neutralizing antibody novel Novel coronavirus omicron outbreak pandemic peptide peptides Proteins recognize reported required S1 and S2 S2 domain SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 variant SARS-CoV-2 variants selected sequence sequences spike Spike surface glycoprotein, Immunogenic, Neutralizing antibody. Spread step subunit Subunit vaccine Surface glycoprotein surface protein surface proteins T-cell T-cell epitope T-cell epitopes the vaccine Vaccine vaccine construct variant variants variants of SARS-CoV-2 Vero Cell viral surface virus virus replication wild type wild-type virus
[DOI] 10.1007/s00253-022-11988-x PMC 바로가기 [Article Type] Article

Immune profile and responses of a novel dengue DNA vaccine encoding an EDIII-NS1 consensus design based on Indo-African sequences

인도-아프리카 서열을 기반으로 하는 EDIII-NS1 컨센서스 디자인을 암호화하는 새로운 뎅기열 DNA 백신의 면역 프로필 및 반응

Article

Published on 2022-05-042022-09-11
Journal: Molecular therapy : the journal of the American So [Category] MERS, 변종, 진단,

[키워드] antibody Antibody-dependent enhancement Antigen antigens clinical isolates coding sequence Consensus consensus sequence conserved COVID-19 pandemic Dengue dengue surveillance. dengue virus DENV-2 DNA DNA vaccine domain domain III EDIII domain emerging viruses envelope protein epitope Epitopes expand Genotype highlight IgG1 immune immune response immunogenic Immunoglobulin India Indo-African interferon isolate mice neutralizing antibody non-structural protein NS1 protein passive transfer protein expression response sequence Sequencing sera serotype serotype-specific staining Stand Structural analysis Surveillance T cell T cell responses transfer translation vaccination Vaccine vaccine candidate Vaccine design Viral Viral variants virulent viruses whole genome Whole genome sequencing
[DOI] 10.1016/j.ymthe.2022.01.013 PMC 바로가기 [Article Type] Article

Structure and dynamics of the SARS-CoV-2 envelope protein monomer

Article

Published on 2022-05-012023-07-08
Journal: Proteins [Category] COVID19(2023년),

[키워드] envelope protein glycosylation membrane curvature membrane protein molecular dynamics palmitoylation SARS-CoV-2
[DOI] 10.1002/prot.26317

Combined Subcutaneous-Intranasal Immunization With Epitope-Based Antigens Elicits Binding and Neutralizing Antibody Responses in Serum and Mucosae Against PRRSV-2 and SARS-CoV-2

에피토프 기반 항원과 결합된 피하-비강내 면역화는 PRRSV-2 및 SARS-CoV-2에 대한 혈청 및 점막의 결합 및 중화 항체 반응을 유도합니다

Article

Published on 2022-03-312022-09-12
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단,

[키워드] Administered Against animal antibodies antibody Antigen antigens Antiviral approaches asymptomatic infection baculovirus binding binding antibody Combination Combined Concentration conserved elicit emerging and re-emerging viruses envelope protein epitope epitope-based antigens evaluate evaluated expressed fluids generate GP5 Humoral response immunization immunization strategy immunized induce Infection inhibited inoculated Interaction intranasal intranasally investigated Local memory response mucosal mucosal antibodies Mucosal immunization nasal Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody New Prevent produced promoted Protein RBD-ACE2 receptor-binding motif recombinant baculovirus recombinant proteins recombinant proteins. reduce response responses SARS-CoV-2 serum serum antibody serum sample subcutaneously the S protein Transmission vaccinated individuals Vaccine design vaginal swabs virus
[DOI] 10.3389/fimmu.2022.848054 PMC 바로가기 [Article Type] Article

Interactions of Co, Cu, and non-metal phthalocyanines with external structures of SARS-CoV-2 using docking and molecular dynamics

Article

Published on 2022-02-282022-10-04
Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 치료제,

[키워드] Adsorption antagonist approach approaches atomic candidate caused Characteristics characterized Cobalt Computational models Computational neuroscience Computational platforms and environments Contamination contribute copper COVID-19 pandemic deviation docking Dynamics envelope protein Gibbs free energy glycoprotein information inhibitor Interaction lethality rate Ligand macromolecules Masks molecular Molecular docking study molecular dynamics New coronavirus occur predict protease Proteases Protein analysis Protein function predictions provided residue SARS-CoV-2 Software solvent spike Structure structures Virtual drug screening virus were used
[DOI] 10.1038/s41598-022-07396-w PMC 바로가기 [Article Type] Article

DNA Vaccines Expressing the Envelope and Membrane Proteins Provide Partial Protection Against SARS-CoV-2 in Mice

엔벨로프 및 막 단백질을 발현하는 DNA 백신은 생쥐에서 SARS-CoV-2에 대한 부분적 보호를 제공합니다

Article

Published on 2022-02-242022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Against caused cellular Cellular immune response cellular response conserved coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-protective DNA DNA vaccine dose effective Electroporation elicited envelope envelope protein Epitopes humoral Humoral immunity Humoral response immune responses immunisation International Intramuscular injection lung tissue membrane membrane protein mice pandemic Partial protection Protein provided public health emergency respiratory robust SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus Significant structural protein structural proteins T-cell epitope target titre Vaccination strategies Vaccination strategy Vaccine vaccine candidate vaccine candidates Vaccines virus
[DOI] 10.3389/fimmu.2022.827605 PMC 바로가기 [Article Type] Article