Post-Mortem RT-PCR Assay for SARS-CoV-2 RNA in COVID-19 Patients’ Corneal Epithelium, Conjunctival and Nasopharyngeal SwabsArticle Published on 2021-09-202022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory syndrome cadaver clinical collected Conjunctival swab Contamination Corneal corneal scraping coronavirus Coronavirus disease 2019 COVID-19 described Diagnosis disease epithelium examined feature hospital moderate Nasopharyngeal swab Novel coronavirus NPs occur ocular Ocular surface Patient patients performed polymerase chain positive Post-mortem promote real-time reverse transcriptase retrieved RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA severe COVID-19 Structure tested the SARS-CoV-2 tissue virus [DOI] 10.3390/jcm10184256 PMC 바로가기 [Article Type] Article
Epidermal Growth Factor Receptor Expression in the Corneal EpitheliumReview Published on 2021-09-132024-09-02 Journal: Cells [Category] 대상포진, [키워드] Cornea epidermal growth factor receptor (EGFR) epithelium homeostasis wound healing [DOI] 10.3390/cells10092409 PMC 바로가기 [Article Type] Review
The Potential of Lung Epithelium Specific Proteins as Biomarkers for COVID-19-Associated Lung InjuryReview Published on 2021-09-082022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] acute respiratory distress affected Biomarker CC16 Cell clinician conditions coronavirus 2 COVID-19 epithelial cell epithelium Infection Inflammation KL-6 lung abnormality Lung injury manifestation Numerous organ pandemic Patient patients with COVID-19 Potential Potential biomarker Protein reported respiratory Respiratory failure Respiratory system SARS-CoV SARS-CoV-2 serum severity Shortness of breath Specific Surfactant proteins syndrome WHO World Health Organization Wuhan, China [DOI] 10.3390/diagnostics11091643 PMC 바로가기 [Article Type] Review
Endocytosis and Transcytosis of SARS-CoV-2 Across the Intestinal Epithelium and Other Tissue BarriersImmunology Published on 2021-09-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome barrier Betacoronavirus cause characterized complexes coronavirus COVID-19 determine diagnostic dissemination endocytosis epithelium extracellular vesicle gastrointestinal tract Immunoglobulin in vitro intestinal intestinal epithelium intestine intestines mechanism MERS MERS-CoV Microfluidics Middle East Model Other overcome Placenta respiratory tract SARS-CoV SARS-CoV-2 syndrome Therapeutic strategies tissue transcytosis transfer Transmission viral particle virus [DOI] 10.3389/fimmu.2021.636966 PMC 바로가기 [Article Type] Immunology
The structural basis of accelerated host cell entry by SARS-CoV-2†SARS-CoV-2에 의한 가속화된 숙주 세포 진입의 구조적 기초†Article Published on 2021-09-012022-09-11 Journal: The Febs Journal [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] accelerate accelerated ACE-2 ACE2-RBD acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme Antiviral strategies antiviral strategy base C-terminal domain causative agent cell entry cellular entry cleavage site conserved Contact contagious contribute coronavirus Coronavirus disease 2019 COVID-19 disease domain effective entry receptor enzyme epithelial epithelium exhibit explain faster Features flat furin furin protease HCoVs high-affinity binding host cell human coronavirus hypothese Interaction leads Mutation N-terminal domain notable NTD other proteases pandemic pandemic coronavirus Proteases Protein protein-protein interaction RBD receptor Receptor-binding domain respiratory respiratory epithelia S protein S1 subunit SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sialic acid sialic acid-binding domain. Spike protein subunit the receptor-binding domain the S protein the S1 subunit the spike protein Tight binding turn Viral viral RBD viral S viral spike [DOI] 10.1111/febs.15651 PMC 바로가기 [Article Type] Article
Transcriptomic Signatures of Airway Epithelium Infected With SARS-CoV-2: A Balance Between Anti-infection and Virus LoadCell and Developmental Biology Published on 2021-08-232022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] Analysis ARDS balance Bioinformatics analysis bystander COVID-19 COVID-19 infection Cytokine storm differentially expressed disease disease severity Effect effective epithelial cell epithelium evaluated expression facilitate Gene Expression gene signature immune response infected cell inhibit Innate immunity load lung epithelial cell maintain Medicine pathway patients with COVID-19 Pneumonia SARS-CoV-2 scRNA seq signature therapeutic drug Therapies therapy uninfected viral infection Viral load viral replication [DOI] 10.3389/fcell.2021.735307 PMC 바로가기 [Article Type] Cell and Developmental Biology
Bordetella Adenylate Cyclase Toxin Elicits Airway Mucin Secretion through Activation of the cAMP Response Element Binding Protein보르데텔라 아데닐레이트 사이클레이스 독소는 cAMP 반응 요소 결합 단백질의 활성화를 통해 기도 점액 분비를 유도한다.Article Published on 2021-08-232024-08-01 Journal: International Journal of Molecular Sciences [Category] 백일해, [키워드] adenylate cyclase toxin Bordetella CAMP CREB epithelium mucin Pertussis toxin [DOI] 10.3390/ijms22169064 PMC 바로가기 [Article Type] Article
Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8 + T cellsSARS-CoV-2에 의한 인간 소장 감염은 활성화된 CD8 + T 세포에 의한 점막 침윤이 특징입니다.Article Published on 2021-08-212022-09-10 Journal: Mucosal Immunology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] accumulation activated addition analyzed Apoptosis Applying biopsies biopsy caused CD8 change characterized claimed complex COVID-19 COVID-19 patients Cytometry demonstrated direct infection disease duodenal epithelial epithelial cells epithelium Evidence Gastrointestinal symptom gastrointestinal symptoms gastrointestinal tract Human immune activation immunohistochemistry infected individuals Infection infiltration intestinal intestinal cell intestinal cells intestinal epithelial cell intestinal epithelial cells lung modulation mucosa mucosal mucosal immune nucleocapsid protein proliferation qRT-PCR regenerative SARS-CoV-2 SARS-CoV-2 infected individuals SARS-CoV-2 pandemic SARS-CoV-2 RNA small intestine subsequent Symptom T cell T cells the SARS-CoV-2 upper airway upper airways Viral viral tropism with COVID-19 [DOI] 10.1038/s41385-021-00437-z PMC 바로가기 [Article Type] Article
Cytosolic replication in epithelial cells fuels intestinal expansion and chronic fecal shedding of Salmonella Typhimurium상피 세포에서의 세포질 복제는 장의 확장과 살모넬라 타이피무리움의 만성 대변 배출을 촉진한다.Article Published on 2021-07-142024-08-21 Journal: Cell Host & Microbe [Category] 살모넬라증, [키워드] autolytic conditional lethal epithelium extrusion intestinal epithelial cell intracytosolic replication Salmonella Typhimurium shedding
Replicative Fitness of a SARS-CoV-2 20I/501Y.V1 Variant from Lineage B.1.1.7 in Human Reconstituted Bronchial Epithelium인간 재구성 기관지 상피에서 혈통 B.1.1.7의 SARS-CoV-2 20I/501Y.V1 변이체의 복제 적합성Observation Published on 2021-07-062022-09-10 Journal: mBio [Category] MERS, SARS, 변종, [키워드] 20I/501Y.V1 B.1.1.7 both virus both viruses bronchial Bronchial epithelium cellular Characteristics circulating competition contribute coronavirus CoV D614G epithelium European Evidence Ex vivo experiment fitness genetic diversity Human in vitro Lineage Lineage B.1.1.7 New coronavirus no difference phenotypic Population regions replaced replicate Replication replication kinetics replicative fitness respiratory Result SARS-CoV-2 strain variant viruses [DOI] 10.1128/mBio.00850-21 PMC 바로가기 [Article Type] Observation