Exploring SARS-COV-2 structural proteins to design a multi-epitope vaccine using immunoinformatics approach: An in silico study면역정보학 접근법을 사용한 다중 에피토프 백신 설계를 위한 SARS-COV-2 구조 단백질 탐색: 실리코 연구Article Published on 2021-06-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료법, [키워드] adjuvant allergenicity analyzed Antigen antigenicity Bioinformatics analysis chimeric China cholera toxin conducted CTL CTL epitope CTL epitopes CTxB cytotoxic T lymphocyte cytotoxic T lymphocytes docked effective envelope epitope Epitope prediction Epitopes evaluate FIVE flexible fused HTL immune response immune responses Immune simulation immunoinformatics in silico In silico cloning in vitro in vivo Interaction linkers membrane molecular molecular dynamics Multi-epitope vaccine N-terminal new virus nucleocapsid physicochemical predicted Proteins receptor reported researchers reverse vaccinology SARS-CoV-2 SARS-CoV-2 vaccines selected spread to Stage structural protein structural proteins T lymphocyte the vaccine TLR4 Toll-like receptor toll-like receptor 4 Toxicity Vaccine vaccine construct was performed [DOI] 10.1016/j.compbiomed.2021.104390 PMC 바로가기 [Article Type] Article
Identification of 22 N-glycosites on spike glycoprotein of SARS-CoV-2 and accessible surface glycopeptide motifs: Implications for vaccination and antibody therapeuticsSARS-CoV-2의 스파이크 당단백질에 있는 22개의 N-글리코사이트 및 접근 가능한 표면 글리코펩타이드 모티프 식별: 백신 접종 및 항체 치료제에 대한 시사점Article Published on 2021-01-092022-09-12 Journal: Glycobiology [Category] 진단, [키워드] acute respiratory syndrome Analysis analyzed antibody Antibody therapeutics antigenic approved binding chymotrypsin coronavirus cryogenic electron microscopy structure crystal structures digestion domain drug electron enzyme epitope Epitope prediction food glycan glycopeptide/SARS-CoV-2. heptad repeat hidden high-mannose human cells identification include influenza vaccine insect cell insect cells majority mechanism Microscopy Modification N-glycans N-terminal domain Other peptide peptide epitope predicted produced recognize SARS-CoV-1 SARS-CoV-2 secreted spike glycoprotein spike glycoproteins Spike protein spike receptor-binding domain Structure sugar Tandem mass spectrometry trypsin vaccination [DOI] 10.1093/glycob/cwaa052 PMC 바로가기 [Article Type] Article
Design of an epitope-based peptide vaccine against the SARS-CoV-2: a vaccine-informatics approachArticle Published on 2020-12-082023-07-01 Journal: Briefings in Bioinformatics [Category] SARS, [키워드] allergenicity COVID-19 Epitope prediction immunogenicity molecular docking population coverage T- and B-cell vaccinomics [DOI] 10.1093/bib/bbaa340 PMC 바로가기
The combination of artificial intelligence and systems biology for intelligent vaccine designReview Published on 2020-11-012023-07-12 Journal: Expert opinion on drug discovery [Category] SARS, [키워드] agent-based models artificial intelligence COVID-19 Epitope prediction immune system modeling Systems biology Vaccine development [DOI] 10.1080/17460441.2020.1791076 [Article Type] Review
Computational design of a novel multi-epitope vaccine against Coxiella burnetiiArticle Published on 2020-10-012023-06-22 Journal: Human immunology [Category] 조류인플루엔자, [키워드] Computational biology Coxiella burnetii Epitope prediction Immunogenic protein Multi-epitope vaccine Q fever [DOI] 10.1016/j.humimm.2020.05.010
Contriving Multi-Epitope Subunit of Vaccine for COVID-19: Immunoinformatics ApproachesImmunology Published on 2020-07-282022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] adaptation all age group Amino acid B cell B cells beta coronavirus binding epitope C-terminal can be used caused codon complex COVID-19 CTL CTL epitope cytotoxic T lymphocyte determine domains EAAAK linker Efficacy ENhance epitope Epitope prediction evaluated experiment experimental validation expression Fatality rate Final functional fusing help histocompatibility complex HTL Immune receptor immunoinformatics immunoinformatics approach in silico In silico cloning Incubation period linkers MHC-I MHC-II molecular docking mRNA Multi-epitope vaccine N-terminal performed positive predicted Prevalence producing Protein public health reduce RNA SARS-CoV-2 SARS-CoV-2 infections secondary structure sequence single-stranded susceptible T lymphocyte TAT the vaccine tlr-3 Treatment Vaccine virus vital role β-defensin [DOI] 10.3389/fimmu.2020.01784 PMC 바로가기 [Article Type] Immunology
Identification and Analysis of Unstructured, Linear B-Cell Epitopes in SARS-CoV-2 Virion Proteins for Vaccine DevelopmentArticle Published on 2020-07-202022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] B-cell B-cell epitope B-cell epitopes bat coronavirus Consensus coronavirus COVID-19 cross-protection development Efficacy epitope Epitope prediction epitope switch event facilitate humans identification immune system immunoinformatics intermediate lack linear mutational processe N proteins nucleic acid-based vaccine overlap pandemic predictor previous study Protein reported SARS-CoV SARS-CoV-2 SARS-CoV-2 isolate secondary structure serum Stage Strains switching transfer translated unfolded protein response Vaccine Variability while zone [DOI] 10.3390/vaccines8030397 PMC 바로가기 [Article Type] Article
Immunoinformatics‐aided identification of T cell and B cell epitopes in the surface glycoprotein of 2019‐nCoVResearch Article Published on 2020-03-032022-11-01 Journal: Journal of medical virology [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus 2019‐nCoV approach Asia B cell epitope binding candidate caused China complexes confirmed case coronavirus COVID‐19 CTL CTL epitope CTL epitopes cytotoxic T lymphocyte death East eight epitope Epitope prediction FIVE glycoprotein histocompatibility complex Hydrogen bond identify immune responses immunoinformatics Interaction MHC MHC class I molecular Molecular dynamics simulation outbreak persistent prevalent Salt Bridge SARS‐CoV‐2 Surface glycoprotein T cell Vaccine development Vaccines viral surface [DOI] 10.1002/jmv.25698 PMC 바로가기 [Article Type] Research Article
Porcine parvovirus VP1/VP2 on a time series epitope mapping: exploring the effects of high hydrostatic pressure on the immune recognition of antigensResearch Published on 2019-06-032023-08-29 Journal: Virology Journal [Category] E형 간염, [키워드] epitope mapping Epitope prediction porcine parvovirus Spot synthesis [DOI] 10.1186/s12985-019-1165-1 PMC 바로가기 [Article Type] Research
Prediction and Validation of Immunogenic Domains of Pneumococcal Proteins Recognized by Human CD4 + T Cells폐렴구균 단백질의 인간 CD4 + T 세포에 의해 인식되는 면역원성 도메인의 예측 및 검증Article Published on 2019-03-252024-07-31 Journal: Infection and Immunity [Category] 폐렴구균 감염증, [키워드] Adaptive immunity CD4+ T cells Epitope prediction HLA-DR restriction MHC pneumococcal proteins pneumococcus Streptococcus pneumoniae [DOI] 10.1128/IAI.00098-19 PMC 바로가기