SARS-CoV-2 Infected Pediatric Cerebral Cortical Neurons: Transcriptomic Analysis and Potential Role of Toll-like Receptors in PathogenesisSARS-CoV-2에 감염된 소아 대뇌 피질 뉴런: 전사체 분석 및 병인에서 유료 유사 수용체의 잠재적 역할Article Published on 2021-07-282022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] ACE2 caspase caspase 8 cells cerebral changes in chemokine chemokines children cortical COVID-19 neurological symptom COVID-19 neurological symptoms deregulation downregulated downregulation downstream ERK expression genes encoding human neuronal cells IKKε increase in increased expression infect infected with SARS-CoV-2 IRF3 JNK mechanism medium nervous system Neurological involvement Neurological symptoms Neuron neuronal next generation sequencing NF-κB Nod-like receptors not express Pathogenesis Pattern recognition pattern recognition receptor pediatric Potential receptor receptors replicate responsible role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins scavenger receptors Sequencing Signaling TLR TLR1 TLR4 TLR6 TLRs TMPRSS2 Toll-like receptor Toll-like receptors TRAF3 transcriptomic analysis transcriptomic profile upregulated upregulation Viral Viral RNA western blot [DOI] 10.3390/ijms22158059 PMC 바로가기 [Article Type] Article
Viral fibrotic scoring and drug screen based on MAPK activity uncovers EGFR as a key regulator of COVID-19 fibrosisMAPK 활성을 기반으로 한 바이러스성 섬유증 스코어링 및 약물 스크리닝은 COVID-19 섬유증의 주요 조절자로서 EGFR을 밝혀냅니다Article Published on 2021-05-272022-09-10 Journal: Scientific Reports [Category] 신약개발, 치료제, [키워드] ACE2 activity Analysis Antiviral antiviral activity approach Cell cell line Cell signalling Cluster cluster of gene complication of COVID-19 correlation COVID-19 COVID-19 progression COVID-19 research COVID-19 treatment Data mining Data processing downregulate drug Drug discovery dual EGF EGFR entry receptor epidermal epidermal growth factor ErbB ERK fibrosis growth factor Host Idiopathic pulmonary fibrosis imaging in vitro infected cells inhibitor inhibitors involved lung cells machine learning MAPK molecular basis Patient phenotype predicted provide pulmonary fibrosis quantified responsible RNA-sequencing SARS-CoV-2 SARS-CoV-2-infected cell SARS-CoV-2-infected cells sequencing data Signaling the cells transcriptomic transcriptomic data Treatment understanding utility Virtual drug screening [DOI] 10.1038/s41598-021-90701-w PMC 바로가기 [Article Type] Article
Physical exercise effects on the brain during COVID-19 pandemic: links between mental and cardiovascular healthCOVID-19 전염병 동안 뇌에 미치는 신체 운동 효과: 정신 건강과 심혈관 건강 간의 연관성Review Published on 2021-04-012022-09-11 Journal: Neurological Sciences [Category] 유전자 메커니즘, [키워드] ACE2 ACE2 expression Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect affected Ang 1-7 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 antiinflammatory Anxiety BDNF binding Brain cardiovascular complications Cardiovascular health caused Chronic diseases Corona Corona virus coronavirus COVID-19 COVID-19 pandemic death Depression disorders Effect Elevation ENhance enzyme ERK exercise FNDC5 Health heart host cell host cells IGF-1 IMPROVE individual induce Infection Inflammation life lung Lungs maintenance Mental mental health Mobility molecular mechanism molecular mechanisms neurological neuronal other tissues outbreak oxygen oxygen supply pandemic pathological mechanism pathway physical physical activity Physical exercise physiological response PI3K Quality of life quarantine Quarantine period receptor reducing SARS-CoV-2 SARS-COV-2 infection Sedentary behavior severe acute respiratory syndrome Coronavirus survival Treatment Virus Disease [DOI] 10.1007/s10072-021-05082-9 PMC 바로가기 [Article Type] Review
Upregulation of DUSP6 impairs infectious bronchitis virus replication by negatively regulating ERK pathway and promoting apoptosisResearch Article Published on 2021-01-112022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] activated antiviral drugs Apoptosis bronchitis cause Cell cell death component contagious disease Coronavirus infection correlated dominant negative DUSP6 ERK ERK1/2 expression Extracellular facilitate facilitated form IBV IBV infection impair Infectious Bronchitis Virus inhibitor Interaction investigated mutant negative regulation Pathogenesis pathway phosphatase Phosphorylation promoted reduced regulate Regulation Replication restrict shown Signaling signaling pathway siRNA suppressed target therapeutic These data Undetermined viral infection viral infections Viral load viral replication virus virus replication [DOI] 10.1186/s13567-020-00866-x PMC 바로가기 [Article Type] Research Article
Computational analysis to repurpose drugs for COVID-19 based on transcriptional response of host cells to SARS-CoV-2SARS-CoV-2에 대한 숙주 세포의 전사 반응을 기반으로 COVID-19에 대한 약물 용도 변경을 위한 전산 분석Research Article Published on 2021-01-072022-09-10 Journal: BMC Medical Informatics and Decision Making [Category] 신약개발, 유전자 메커니즘, 치료제, [키워드] activated addition affected Analysis approach caused clinical trials coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 treatment Critical CXCR6 Data analysis death rate Dexamethasone drug drug-target effective effective drug effective drugs epithelial cell epithelial cells ERK evaluated facilitate Gene Expression high mortality rate host cell host cells human lung human lung epithelial cells identify immune Infection Integrative analysis involved IRF7 Jak-STAT JNK life cycle MAPK molecular MYD88 NFkB Ontology pandemic pathway Pathways receiving reduce reported Repurposed drug Repurposed drugs resources respiratory Respiratory Support Result SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling signaling pathway signaling pathways significantly STAT therapy transcriptional response Treatment treatments for COVID-19 Vaccine [DOI] 10.1186/s12911-020-01373-x PMC 바로가기 [Article Type] Research Article
Computational analysis to repurpose drugs for COVID-19 based on transcriptional response of host cells to SARS-CoV-2Research Article Published on 2021-01-072022-10-27 Journal: BMC Medical Informatics and Decision Making [Category] COVID-19, [키워드] activated addition affected Analysis approach caused clinical trials coronavirus 2 COVID-19 COVID-19 patient Critical Data analysis death rate Dexamethasone drug drug-target effective effective drug epithelial cell ERK evaluated facilitate Gene Expression high mortality rate host cell host cells human lung identify immune Infection Integrative analysis involved Jak-STAT JNK MAPK molecular Ontology pandemic pathway receiving reduce reported Repurposed drug resources respiratory Respiratory Support Result SARS-CoV-2 Signaling signaling pathway significantly STAT therapy transcriptional response Treatment treatments for COVID-19 Vaccine [DOI] 10.1186/s12911-020-01373-x PMC 바로가기 [Article Type] Research Article
Computational analysis to repurpose drugs for COVID-19 based on transcriptional response of host cells to SARS-CoV-2Research Article Published on 2021-01-072022-10-27 Journal: BMC Medical Informatics and Decision Making [Category] Coronavirus, COVID-19, [키워드] activated addition affected Analysis approach caused clinical trials coronavirus 2 COVID-19 COVID-19 patient Critical Data analysis death rate Dexamethasone drug drug-target effective effective drug epithelial cell ERK evaluated facilitate Gene Expression high mortality rate host cell host cells human lung identify immune Infection Integrative analysis involved Jak-STAT JNK MAPK molecular Ontology pandemic pathway receiving reduce reported Repurposed drug resources respiratory Respiratory Support Result SARS-CoV-2 Signaling signaling pathway significantly STAT therapy transcriptional response Treatment treatments for COVID-19 Vaccine [DOI] 10.1186/s12911-020-01373-x PMC 바로가기 [Article Type] Research Article
NMDA receptor antagonists attenuate intrathecal morphine-induced pruritus through ERK phosphorylationResearch Published on 2018-06-282024-09-02 Journal: Mol Brain [Category] 대상포진, [키워드] Analgesia ERK Intrathecal morphine NMDA receptor antagonist pruritus [DOI] 10.1186/s13041-018-0379-2 PMC 바로가기 [Article Type] Research
NS1-binding protein abrogates the elevation of cell viability by the influenza A virus NS1 protein in association with CRKLArticle Published on 2013-11-292023-06-24 Journal: Biochemical and Biophysical Research Communication [Category] 신종인플루엔자, [키워드] 3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cell proliferation CrkII CRKL ERK extracellular signal-regulated kinase glutathione S-transferase GST HEK human embryonic kidney MTT non-structural protein 1 NS1 NS1-binding protein NS1-BP SH Src-homology [DOI] 10.1016/j.bbrc.2013.11.011
In vivo, in vitro, and in silico studies suggest a conserved immune module that regulates malaria parasite transmission from mammals to mosquitoesarticle Published on 2013-10-312024-09-01 Journal: Case Reports in Obstetrics and Gynecology [Category] 말라리아, [키워드] Anopheles stephensi 60A Anopheles stephensi NOS As60A AsNOS ERK ERK kinase kinase extracellular signal-regulated kinase iNOS JNK Jun N-terminal kinase malaria mammalian inducible NOS MAPK MAPK of 38 kilo Dalton molecular weight mathematical model MEK mitogen-activated protein kinase nitric oxide nitric oxide synthase NO NOS ODE ordinary differential equation p38 MAPK PBS phosphate-buffered saline reactive nitric oxide species RNS TGF-β1 transforming growth factor-β1 [Article Type] article