Periodontitis promotes the expression of gingival transmembrane serine protease 2 (TMPRSS2), a priming protease for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)치주염은 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 프라이밍 프로테아제인 치은 막횡단 세린 프로테아제 2(TMPRSS2)의 발현을 촉진합니다Article Published on 2022-06-012022-09-11 Journal: Journal of oral biosciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome Analysis analyzed anti-TMPRSS2 antibody cell membrane ChIP coronavirus correlation COVID-19 dataset datasets ESR1 Estrogen estrogen receptor Express expressed expression Gene Expression Gene Expression Omnibus GEO GEO dataset Gingiva Human increase increased expression investigated keratinocytes Ligand oral cavity Periodontitis priming promote promoter promoter region protease Quantitative responsible reverse transcription SARS-CoV-2 SARS-CoV-2 spike protein screened Serine Spike protein the SARS-CoV-2 tissue tissues TMPRSS2 TMPRSS2 expression transcription factor transcription factors transmembrane serine protease transmembrane serine protease 2 was performed western blot Western blot analysis [DOI] 10.1016/j.job.2022.04.004 PMC 바로가기 [Article Type] Article
A phase 2 randomized, double-blinded, placebo-controlled, multicenter trial evaluating the efficacy and safety of raloxifene for patients with mild to moderate COVID-19Research article Published on 2022-05-122022-10-05 Journal: EClinicalMedicine [Category] 신약개발, 임상, [키워드] Action acute respiratory syndrome adaptive clinical testing consumer coronavirus disease-2019 Coronavirus-2 COVID COVID-19 COVID-19 disease current decrease doses double-blinded Effect Efficacy and safety Emergency Endpoint enrolled Estrogen European Commission evaluate Evidence finding FIVE funding hospitalized patients immunomodulator indications instrument Italian Italy lack mechanical ventilation Medicine Mild Ministry of Health mitigate moderate Moderate COVID-19 modulate multicenter Multicenter trial Nasopharyngeal swab Occurrence participant Patient pharmacological Phase 2 study Placebo placebo-controlled placebo-controlled trial Prevent Primary outcome progression proinflammatory cytokines proportion raloxifene Randomized receive Registered Replication reported Safety safety profile SARS-CoV-2 Selective estrogen receptor modulator (SERM) Serious Adverse Events Seven supplemental oxygen Supplemental oxygen therapy Support supported therapeutic option treat Treatment Trial undetectable viral shedding [DOI] 10.1016/j.eclinm.2022.101450 [Article Type] Research article
Sex Differences in Influenza: The Challenge Study ExperienceArticle Published on 2022-02-152023-06-14 Journal: The Journal of Infectious Diseases [Category] Fulltext, 신종인플루엔자, [키워드] Estrogen hemagglutinin Influenza neuraminidase sex differences Testosterone [DOI] 10.1093/infdis/jiab422 PMC 바로가기
SARS-CoV-2 infection negatively affects ovarian function in ART patientsSARS-CoV-2 감염은 ART 환자의 난소 기능에 부정적인 영향을 미칩니다Article Published on 2022-01-012022-09-11 Journal: Biochimica et biophysica acta. Molecular basis of [Category] MERS, SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Angiogenesis ART patient Cell cell cultures Cell migration cell type cell types changes in coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients decrease demonstrated Effect endothelial Endothelial cell endothelial cells ERα Estrogen expression Factors female female reproductive system follicular Follicular fluid granulosa granulosa cell growth factor H2Ax heart IgG IgG antibodies IgG antibody IL-10 IL-1β Infection intestine investigated microenvironment not differ oocytes organs ovarian Patient positive Protein protein expression Regulatory reported reproductive reproductive system respiratory retrieved Retrieved oocytes SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies SARS-COV-2 infection screened severe acute respiratory syndrome Coronavirus significantly significantly higher significantly lower STAR stimulated target tissue target tissues testes the SARS-CoV-2 Vascular vascular endothelial growth factor VEGF while [DOI] 10.1016/j.bbadis.2021.166295 PMC 바로가기 [Article Type] Article
Immuno-Endocrinology of COVID-19: The Key Role of Sex HormonesCOVID-19의 면역 내분비학: 성 호르몬의 주요 역할Review Published on 2021-12-022022-09-11 Journal: Frontiers in Endocrinology [Category] SARS, 유전자 메커니즘, [키워드] Adaptive immune response androgen Clinical studies clinical study coronavirus coronavirus 2019 disease COVID-19 COVID-19 pathogenesis COVID-19 severity Cytopathic effect disease severity element Estrogen Evidence Factor Factors fatality Gender Gene regulation hormone hyper-inflammatory response identify immune response immune responses immuno-endocrinology include Infection Injury involved mechanism optimization Pathogenesis personalised regulated Regulation role SARS-CoV2 severity Sex sex hormone Sex hormones susceptibility target targets therapeutic intervention tissue injury tissue specific Treatment outcome Trial [DOI] 10.3389/fendo.2021.726696 PMC 바로가기 [Article Type] Review
Women’s knowledge about the genitourinary syndrome of menopause: adherence to its treatments in the COVID-19 era in a sample of them: COMEM-GSM studyObservational Study Published on 2021-11-302022-10-04 Journal: BMC Women's Health [Category] MERS, SARS, 임상, [키워드] adherence age Analysis asked Care Comparative Compliance conducted confinement confinement period coronavirus COVID-19 Diagnosis Estrogen extension Genitourinary syndrome of menopause Health knowledge lack Local Lubricant menopausal status Menopause MOST objective pandemic Result Sexuality significantly Symptom syndrome Treatment Vaginal dryness vulvovaginal women [DOI] 10.1186/s12905-021-01548-2 PMC 바로가기 [Article Type] Observational Study
Golden Syrian Hamsters as a Model for Revisiting the Role of Biological Sex Differences in SARS-CoV-2 InfectionSARS-CoV-2 감염에서 생물학적 성별 차이의 역할을 재검토하기 위한 모델로서의 골든 시리아 햄스터Commentary Published on 2021-11-232022-09-12 Journal: mBio [Category] MERS, SARS, 진단, [키워드] Affect approach Biological body mass Chest computed tomography clinical feature Clinical features Computed tomography coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated difference disease pathology Estrogen Evidence females hamster Hypothesis immune response Inflammatory response lung Lung infection male mBio Model outcomes Pathogenesis primary determinant probe Quantitative role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis Sex Sex difference Support Syrian hamster viral infections viral replication [DOI] 10.1128/mBio.01848-21 PMC 바로가기 [Article Type] Commentary
Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers입원 성별 바이오 마커에 의해 SARS-COV-2에 의해 감염된 환자의 호흡기 부전 예측Research Published on 2021-11-222022-08-31 Journal: Biology of Sex Differences [Category] MERS, SARS, 바이오마커, [키워드] 17β-estradiol ACE2 acute respiratory distress acute respiratory distress syndrome Admission affecting analysed Angiotensin1-7 ARDS association Biomarker Biomarkers choice circulating COVID-19 COVID-19 patient COVID-19 severity Definition Deterioration discharged estradiol Estrogen female female patient Female patients females Gender hospital Hospitalization identify lymphocyte Lymphocytes male males neutrophil neutrophil count Occurrence outcome Patient plasma plasma biomarker Plasma level Plasma levels predict predicted Predictive progression respiratory respiratory distress Respiratory failure Result SARS-CoV-2 severe respiratory failure severity Sex Sex difference sex hormone Sex hormones specific biomarker syndrome Testosterone were measured worsening [DOI] 10.1186/s13293-021-00407-x PMC 바로가기 [Article Type] Research
Structural and Functional Analysis of Female Sex Hormones against SARS-CoV-2 Cell EntryArticle Published on 2021-10-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 receptor alveolar cells COVID-19 disrupt ENhance Estrogen estrogenes Evidence female females glycosylation hormone human ACE2 human ACE2 receptor Interaction male mechanism molecular basis Protein reduced SARS-CoV-2 Severe infection sex hormone Sex hormones Spike protein susceptible the SARS-CoV-2 the SARS-CoV-2 virus therapy underlie variety [DOI] 10.3390/ijms222111508 PMC 바로가기 [Article Type] Article
Possible Risk of Thrombotic Events following Oxford-AstraZeneca COVID-19 Vaccination in Women Receiving EstrogenReview Article Published on 2021-10-252022-10-27 Journal: BioMed Research International [Category] COVID-19, [키워드] addition birth control blood clot ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine COVID-19 develop drug Estrogen follicular help Oxford-AstraZeneca receive receiving reduce risk Side effect thrombosis Thrombus Vaccine women [DOI] 10.1155/2021/7702863 PMC 바로가기 [Article Type] Review Article