Developing evolution-resistant drugs for COVID-19COVID-19에 대한 진화 내성 약물 개발Editorial Published on 2022-07-262022-09-11 Journal: eLife [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료제, [키워드] Affect COVID-19 deep mutational scanning develop Developing drug effective Evolutionary biology help Infectious disease main protease Microbiology MPro Mutation protease researcher S. cerevisiae SARS-CoV-2 variant virus [DOI] 10.7554/eLife.81334 PMC 바로가기 [Article Type] Editorial
Comprehensive fitness landscape of SARS-CoV-2 M pro reveals insights into viral resistance mechanismsSARS-CoV-2 M pro의 종합적인 피트니스 환경은 바이러스 저항 메커니즘에 대한 통찰력을 보여줍니다Article Published on 2022-06-202022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition Amino acid amino acid changes amino acids analyzed Anti-viral drugs can be used cleave Complete Comprehensive conserved contribute Coronavirus-2 correlated Critical deep mutational scanning deep sequencing defined drug drug design drug resistance Effect effective elicit evade Evolution Evolutionary biology expression functional human population Infectious disease inhibitor inhibitors life cycle M pro main protease mechanism Microbiology MPro Mutation network new strain performed physically protease Protein reduced reveal S. cerevisiae SARS-CoV-2 SARS-CoV-2 main protease selection pressure Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Toxicity Vaccines variant viral life cycle Viral resistance virulent yeast [DOI] 10.7554/eLife.77433 PMC 바로가기 [Article Type] Article
Protocol to isolate and assess spike protein cleavage in SARS-CoV-2 variants obtained from clinical COVID-19 samplesArticle Published on 2022-06-132022-10-05 Journal: STAR protocols [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] cell entry cellular proteases cleavage cleaved Complete COVID-19 sample ENhance Evolutionary biology facilitate in viral include Isolation Microbiology Nasopharyngeal swab patients with COVID-19 protocol SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2-infected cells spike mutation Spike protein supernatant [DOI] 10.1016/j.xpro.2022.101502 [Article Type] Article
Selection for infectivity profiles in slow and fast epidemics, and the rise of SARS-CoV-2 variants느리고 빠른 전염병 및 SARS-CoV-2 변종의 증가에 대한 감염성 프로파일 선택Article Published on 2022-05-192022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, [키워드] adaptation Alpha alpha and delta variants assessment assessments Characteristics characterized Community Delta delta variant Delta variants develop England Epidemic Epidemics epidemiological Epidemiology estimate Europe Evaluating Evolutionary biology faster Frequency Generation time global health growth growth advantage help increase knowledge pandemic parameter profile risk Risk assessment SARS-CoV-2 SARS-CoV-2 variant Secondary infection secondary infections Selection statistical framework strain Strains the timing Transmission variant variants variants of concern viruses [DOI] 10.7554/eLife.75791 PMC 바로가기 [Article Type] Article
The evolution of powerful yet perilous immune systems강력하지만 위험한 면역 체계의 진화Review Published on 2022-02-012022-09-12 Journal: Trends in immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addition benefit complement coronavirus disease COVID-19 cytokine Cytokines Defense Evolution Evolutionary biology example explain Goldilocks help immune responses immune system immunopathological immunopathology individual Infection mammalian natural selection optimality. predict resource responses suffered susceptibility symbiont [DOI] 10.1016/j.it.2021.12.002 PMC 바로가기 [Article Type] Review
Spontaneous mutation rate estimates for the principal malaria vectors Anopheles coluzzii and Anopheles stephensi주요 말라리아 매개체인 Anopheles coluzzii와 Anopheles stephensi의 자발적 돌연변이율 추정치Article Published on 2022-01-072024-08-08 Journal: Burma Med J [Category] 말라리아, [키워드] Entomology Evolutionary biology Evolutionary genetics Mutation Sequencing [DOI] 10.1038/s41598-021-03943-z PMC 바로가기 [Article Type] Article
Mutational spectrum of SARS-CoV-2 during the global pandemic세계적 대유행 동안 SARS-CoV-2의 돌연변이 스펙트럼Article Published on 2021-08-272022-09-10 Journal: Experimental & Molecular Medicine [Category] MERS, SARS, 변종, [키워드] accumulate Analysis Asia base collected collection time coronavirus COVID-19 pandemic cytosine directional ENhance equilibrium Evidence evidence of Evolution Evolutionary biology exhibit extreme genetic material Genome Genome evolution genome sequence global pandemic guanine help human population information interactions monitoring much higher Mutation mutational processe mutational processes mutational spectrum natural selection nucleic acid predict reached replaced REPLACED BY researcher responsible SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 mutations SARS-CoV-2 viral infection SARS-CoV-2 virus Science sequence South Korea Spectrum substitutions technology the SARS-CoV-2 genome the SARS-CoV-2 virus Transmission uracil Viral viral genes viral genome sequence viral genome sequences viral infection Viral transmission virus viruses was performed [DOI] 10.1038/s12276-021-00658-z PMC 바로가기 [Article Type] Article
Inferring the ecological niche of bat viruses closely related to SARS-CoV-2 using phylogeographic analyses of Rhinolophus speciesRhinolophus 종의 phylogeographic 분석을 사용하여 SARS-COV-2와 밀접한 관련된 BAT 바이러스의 생태 학적 틈새를 추론Article Published on 2021-07-122022-09-10 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome coronavirus affected analysed Analysis Animal migration Asia bat bat virus bat viruses bat-CoV bats Biogeography China coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 pandemic Cytochrome C cytochrome c oxidase dispersal ecological Ecological modelling ecological niche ecological niches Evolutionary biology Evolutionary ecology genetic diversity genomic Haplotype haplotypes human population human populations humans include Infectious diseases less mainland Southeast Asia mitochondrial occur pandemic Pandemics Population Population genetics predicted Recombination Region reported reservoir reservoirs respiratory risk SARS-CoV SARS-CoV-2 SARS-CoV2 sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 subunit Surveillance transitional zone viral infection virus viruses zone [DOI] 10.1038/s41598-021-93738-z PMC 바로가기 [Article Type] Article
Single-nucleotide conservation state annotation of the SARS-CoV-2 genomeSARS-CoV-2 게놈의 단일 염기 보존 상태 주석Article Published on 2021-06-032022-09-10 Journal: Communications Biology [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] applied assist can be used Comparative genomics coronavirus Coronaviruses CoV Ernst Evolutionary biology functional consequence functional consequences Genes Genome Infectious diseases information Kwon mutations predict protein domains Region resource SARS-CoV-2 genome SARS-CoV-2 mutations sequence Sequence alignment sequence alignments Sequence annotation severity of COVID-19 the SARS-CoV-2 genome Variation [DOI] 10.1038/s42003-021-02231-w PMC 바로가기 [Article Type] Article
On the origin and evolution of SARS-CoV-2Review Article Published on 2021-04-162022-10-31 Journal: Experimental & Molecular Medicine [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Atlanta contributed coronavirus coronavirus disease COVID-19 Critical disease Effect effective effort Epidemics events Evidence Evolution Evolution of SARS-CoV-2 Evolutionary biology exhibit facilitated functional Genetic Genome global pandemic growth help Host host cells hosts human cell human population humans infecting Infectious diseases mammalian cells MERS molecular natural selection New Other outbreak Outbreaks pandemic Pandemics Phylogenetic Prevent Protein random Recombination recombination event Region regions responsible resulting S protein SARS-CoV-2 Spread technology the SARS-CoV-2 the SARS-CoV-2 genome the spike protein trajectory USA Variability variants of SARS-CoV-2 viral entry virus zoonotic origin [DOI] 10.1038/s12276-021-00604-z PMC 바로가기 [Article Type] Review Article