Understanding COVID-19: From Dysregulated Immunity to Vaccination Status QuoImmunology Published on 2021-11-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] 2019-nCoV acute respiratory syndrome animal models beta-coronavirus coronavirus coronavirus disease COVID-19 cross death dysregulated immune response etiological agent experimental model experimental models immune responses Infectious disease Novel viruses Personalized medicine public health SARS-CoV-2 status understanding Vaccine Vaccine development [DOI] 10.3389/fimmu.2021.765349 PMC 바로가기 [Article Type] Immunology
Viral and Bacterial Co-Infections in the Lungs: Dangerous LiaisonsReview Published on 2021-08-302022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Antibiotic resistance Antiviral Bacteria bacterial superinfection Co-infection Co-infections complex diagnostic effective Evolution experimental model functional host cell immunological in vitro in vivo Infection influenza infection Influenza virus influenza viruses Interaction knowledge mechanism Microbiome physiological public health respiratory respiratory infection respiratory infections respiratory syncytial virus respiratory tract respiratory virus respiratory viruses RSV SARS-CoV-2 severity Superinfections therapeutic therapeutic approaches [DOI] 10.3390/v13091725 PMC 바로가기 [Article Type] Review
The Immune System Throws Its Traps: Cells and Their Extracellular Traps in Disease and ProtectionReview Published on 2021-07-262022-10-31 Journal: Cells [Category] COVID-19, [키워드] adaptive immune responses Autoimmune B lymphocytes basophil ETs basophils CD4+ CD8+ T lymphocytes Cell collected COVID-19 death dendritic cell ETs different cell Diseases DNA eosinophil ETs eosinophils Evidence Evolution Ex vivo experimental model extracellular trap extracellular traps (ETs) human biological material in vitro in vivo information involved knowledge lymphocyte ETs macrophage ETs macrophages mast cell ETs Mast cells mechanism mechanisms neutrophil Neutrophils neutrophils ETs non-infectious occurred plasmacytoid dendritic cells Population protection System T lymphocytes thrombotic [DOI] 10.3390/cells10081891 PMC 바로가기 [Article Type] Review
SARS-CoV-2 antibodies seroprevalence in dogs from France using ELISA and an automated western blotting assayResearch Paper Published on 2021-07-182022-10-28 Journal: One Health [Category] COVID-19, [키워드] absence anti-SARS-CoV-2 antibodies assays automated canine Clinical signs Coronaviruses correlation COVID-19 cross-reactivity diagnosis of SARS-CoV-2 dog ELISA epidemiological surveillance Epidemiosurveillance experimental model France genomic data healthy Hypothesis incidence multiple mutation one health pandemic performed populations positive Region SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 seroprevalence sera serological test serology significant difference significantly higher Surveillance susceptibility susceptible variant Viral transmission [DOI] 10.1016/j.onehlt.2021.100293 PMC 바로가기 [Article Type] Research Paper
COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomesCOVID-19 가상 환자 코호트는 질병 결과를 주도하는 면역 메커니즘을 제안합니다Research Article Published on 2021-07-142022-09-10 Journal: PLoS Pathogens [Category] SARS, 바이오마커, [키워드] accelerated Analysis approach Biomarker Biomarkers calibrated CD8 clinically Cohort Concentration COVID-19 Critical diagnostic disease Diversity driver Drivers driving expand experimental model experimental models feature identifying IFN IL-6 immune mechanism immune response immune responses immunological immunopathology in silico individual infected cell Inflammation inflammatory disease Intervention lead Longitudinal data Macrophage mathematical mathematical model maximum concentration outcome pathogen Pathogens Patient patient cohort patients Phenotypes predicted production rates reduced reducing regulate responses robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe COVID-19 Support T cell T cell depletion therapeutic targets treatment approaches Type I IFN understanding [DOI] 10.1371/journal.ppat.1009753 PMC 바로가기 [Article Type] Research Article
Vagus Nerve Stimulation: A Potential Adjunct Therapy for COVID-19Medicine Published on 2021-05-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome adjunct Anti-inflammatory approach attenuate cause clinical trial clinical trials Complication coronavirus coronavirus disease Corticosteroids COVID-19 COVID-19 patient Cytokine storm death rate described effective effective drugs effort evaluated excessive inflammation experimental model help immunological Inflammation Inflammatory inflammatory disease inhibitor Intravenous immunoglobulin investigated management modulating nerve nerve stimulation neuromodulation non-drug therapy organ outcome pathophysiology pathway Patient Potential Preliminary data programmed cell death Protein reduce reducing Research SARS-CoV-2 Sepsis the cytokine storm therapeutic therapeutic strategy therapy Tocilizumab Topic Treatment Trial Vagus Vagus nerve stimulation [DOI] 10.3389/fmed.2021.625836 PMC 바로가기 [Article Type] Medicine
Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based StudyArticle Published on 2021-05-052022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] acute lung injury addition analyzed association benefit calcitriol chronic Chronic kidney disease controls COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 severity dose Effect experimental model individual Mortality multivariable outcome Patient reduced reduced risk renal function risk SARS-CoV2 infection severe COVID-19 shown treated patients Treatment variable Vitamin D [DOI] 10.3390/biomedicines9050509 PMC 바로가기 [Article Type] Article
SARS-CoV-2: Pathogenesis, Molecular Targets and Experimental ModelsPharmacology Published on 2021-04-222022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE-2 acute respiratory syndrome Antiviral blood vessel organoid Calu-3 cause cell line cells clinical sample coronavirus COVID-19 develop drug design Drug discovery epithelial cell epithelial cells experimental model experimental models expression H1299 HEK-293 human Angiotensin-converting enzyme human lung inefficient Infection intestinal epithelial cells Intestinal Organoids investigated Laboratory lung organoids Model molecular molecular target Molecular targets morbidity and mortality mouse model Novel coronavirus outbreak outcomes pandemic Pathogenesis potential molecular Protein recent receptor Research researcher SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection sequencing data spike target targets the SARS-CoV-2 therapeutic transgenic Treatment outcome Vero cells viral genome viral life cycle viral pathogen viral pathogenesis Viral protein viral titer X-ray [DOI] 10.3389/fphar.2021.638334 PMC 바로가기 [Article Type] Pharmacology
Cell-type-resolved quantitative proteomics map of interferon response against SARS-CoV-2Article Published on 2021-04-202022-10-30 Journal: iScience [Category] COVID-19, [키워드] absence Abstract antiviral assay Biology Caco-2 Caco2 Caco2 cells Calu-3 Cell Cell Biology cell line cellular pathways cellular response Characteristics Cytopathic effect dysregulated experimental model growth Huh7 HUH7 cells human cell lines interferon response interferon signaling Laboratory pathogenicity performed Protein proteomics Quantitative Regulation SARS-CoV-2 SARS-COV-2 infection susceptibility susceptible susceptible cell Swedish Variability Variation Virology virus virus production viruses [DOI] 10.1016/j.isci.2021.102420 PMC 바로가기 [Article Type] Article
Current Status of Putative Animal Sources of SARS-CoV-2 Infection in Humans: Wildlife, Domestic Animals and PetsReview Published on 2021-04-172022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] ACE2 angiotensin-converting enzyme 2 animal animal reservoirs biological property body temperature companion animals coronavirus COVID-19 COVID-19 infection COVID-19 pandemic current domestic animals experimental model expression Factors ferrets genetic background hamsters Host Human in vitro in vivo infections Interaction intervene modes of transmission Other pets predicted receptor risk rodent SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission Source Spike protein Spread status susceptibility susceptible the SARS-CoV-2 These data viral shedding virus wild animals wildlife zoonosis [DOI] 10.3390/microorganisms9040868 PMC 바로가기 [Article Type] Review