experimental model – Communicable Diseases Research

Comparative SARS-CoV-2 Omicron BA.5 variant and D614G-Wuhan strain infections in ferrets: insights into attenuation and disease progression during subclinical to mild COVID-19

Veterinary Science Original Research

Published on 2024-08-152024-09-05
Journal: Frontiers in Veterinary Science [Category] update2024,

[키워드] attenuation experimental model ferrets omicron Pathogenesis SARS-CoV-2
[DOI] 10.3389/fvets.2024.1435464 PMC 바로가기 [Article Type] Veterinary Science Original Research

Antiviral potential of diminazene aceturate against SARS-CoV-2 proteases using computational and in vitro approaches

Article

Published on 2022-11-012022-11-15
Journal: Chemico-biological interactions [Category] SARS, 치료제,

Choosing a cellular model to study SARS-CoV-2

Article

Published on 2022-10-212022-11-15
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 치료기술, 치료제,

Promotion of neutralizing antibody-independent immunity to wild-type and SARS-CoV-2 variants of concern using an RBD-Nucleocapsid fusion protein

RBD-뉴클레오캡시드 융합단백질을 이용한 관심대상 야생형 및 SARS-CoV-2 변이체에 대한 중화항체 비의존성 면역 촉진

Article

Published on 2022-08-172022-09-11
Journal: Nature Communications [Category] SARS, 변종, 임상, 진단, 치료기술, 치료법,

[키워드] ablated angiotensin antibody Antigen B cell B cells Blood CD4 CD8 chimeric circumvent Clinical outcome convertase COVID-19 convalescent donors COVID-19 vaccine COVID-19 vaccines Delta Depletion detectable effector T cell effector T cells elicit elicited experimental model experimental models fusion protein generate hamster IFN-γ Immune escape Immunity immunization IMPROVE inactivated indicated individual Infection infection with SARS-CoV-2 less lethality levels of antibody Lung inflammation mice NAbs Neutralizing Neutralizing antibodies neutralizing antibody nucleocapsid omicron promote promotion PROTECT Protein protocol protocols RBD RBD protein Receptor binding domain reduction robust SARS-CoV-2 SARS-CoV-2 isolates SARS-CoV-2 vaccine SARS-CoV-2 variant shown spike Spin T cell T cells transferred vaccination Vaccine variants variants of concern Viral Viral load virus wild type wild-type
[DOI] 10.1038/s41467-022-32547-y PMC 바로가기 [Article Type] Article

Cell and Animal Models for SARS-CoV-2 Research

SARS-CoV-2 연구를 위한 세포 및 동물 모델

Review

Published on 2022-07-092022-09-11
Journal: Viruses [Category] COVID19(2023년), SARS, 치료제,

Recapitulating infection, thermal sensitivity and antiviral treatment of seasonal coronaviruses in human airway organoids

인간 기도 오르가노이드에서 계절성 코로나바이러스의 감염, 열 민감도 및 항바이러스 치료 요약

Article

Published on 2022-07-012022-09-11
Journal: EBioMedicine [Category] 치료제,

[키워드] 229E Airway organoids Analysis antiviral activity antiviral therapy Antiviral treatment approved conditions Coronavirus infection Coronavirus infections COVID COVID19 development experimental model facilitate favor funding help host response Human human airway Infection infections Infectious virus inhibited interactions Kinetics medication medications Mild molnupiravir Netherland NL63 OC43 occur organization Organoid Pathogenesis phenotype populations Remdesivir replicate Replication Research research and development resulting RNA sequencing robust seasonal seasonal coronavirus seasonal coronaviruses severe complication severe complications Society Support supported temperature tested therapeutic thermal Thermal sensitivity Transcriptome transcriptomic Transmissibility upper respiratory tract viral replication virus replication Virus-host interaction Virus-host interactions was performed was tested
[DOI] 10.1016/j.ebiom.2022.104132 PMC 바로가기 [Article Type] Article

Possible kidney-lung cross-talk in COVID-19: in silico modeling of SARS-CoV-2 infection

COVID-19에서 가능한 신장 폐 크로스 토크 : SARS-COV-2 감염의 실리코 모델링에서

Research Article

Published on 2022-02-052022-09-10
Journal: BMC Nephrology [Category] COVID19(2023년), Fulltext, MERS, SARS, 유전자 메커니즘,

[키워드] ACE2 Acute kidney injury affected AKI angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach Candidates caused cell entry change changes in COVID receptors COVID-19 COVID-19 infection cross-talk dataset downregulated Effects enzyme evaluated experimental model experimental models expression fold Gene Expression Genes Genomics hypothese in silico in silico analysis in silico Approach Inhbb Injury Invasion involved kidney Kidney-lung cross-talk kidneys Lcn2 leads lung Lung injury Lungs Maff mechanical ventilation mechanism Microarray molecular mouse model Mouse models organs Pneumonia progression protease question Result reveal SARS-CoV-2 SARS-COV-2 infection Serine serine 2 SOCS3 target targets TMPRSS2 transmembrane transmembrane protease serine 2 upregulated while
[DOI] 10.1186/s12882-022-02682-1 PMC 바로가기 [Article Type] Research Article

ABO blood grouping and COVID-19: a hospital-based study in Eastern India

Research

Published on 2022-01-202022-11-01
Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19,

[키워드] 95% CI ABO ABO blood grouping ABO blood type ACE acute respiratory syndrome addition age analyzed antibody association Blood Blood Group Cell control group controls coronavirus coronavirus disease COVID COVID 19 COVID-19 Critical care disease disease severity enzyme experimental model groups Hepatitis higher risk highest Host ICU admission in viral India Infection inhibit Interaction involved Microsoft Excel outbreak Pathogenesis Patient polymerase chain positive positive patient Prevalence Previous studies qRT-PCR Quantitative Real-time PCR receptor recorded Result Retrospective study risk factor SARS-CoV2 severity shown statistical susceptibility viral disease Viral load virus
[DOI] 10.1186/s43042-022-00225-9 PMC 바로가기 [Article Type] Research

J2N-k hamster model simulates severe infection caused by severe acute respiratory syndrome coronavirus 2 in patients with cardiovascular diseases

J2N-k 햄스터 모델은 심혈관 질환 환자에서 중증 급성 호흡기 증후군 코로나바이러스 2로 인한 심각한 감염을 시뮬레이션합니다.

Article

Published on 2022-01-012022-09-11
Journal: Journal of virological methods [Category] SARS, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal model animal models Cardiomyopathy cardiovascular disease cardiovascular diseases caused clade condition coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 displaying dose experimental model feature golden Syrian hamster hamster hamsters higher risk Human imperative Infection J2N-k hamster lethal dose lung Lung injury Lungs median median lethal dose Mild morbidity morbidity and mortality pandemic pathological Patient plaque-forming unit reported researcher SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Severe infection Therapeutics Vaccine viral genome viral genomes viral titer
[DOI] 10.1016/j.jviromet.2021.114306 PMC 바로가기 [Article Type] Article

Neurological complications and infection mechanism of SARS-CoV-2

SARS-CoV-2의 신경학적 합병증 및 감염 기전

Review

Published on 2021-11-232022-09-12
Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 진단, 치료제,