Using Explainable Machine Learning to Improve Intensive Care Unit Alarm SystemsArticle Published on 2021-10-272022-10-29 Journal: Sensors (Basel, Switzerland) [Category] Coronavirus, MERS, SARS, [키워드] Additive age alarm alarms Analysis AUROC classifiers continuous monitoring COVID-19 pandemic Critical database evaluated explainable machine learning explanation feature generate group Health healthcare personnel highest ICU intensive care unit machine learning methodology MIMIC Mortality Patient patient monitoring patients predict Research sensors System These data threshold threshold value variable [DOI] 10.3390/s21217125 PMC 바로가기 [Article Type] Article
Detection of COVID-19 Patients from CT Scan and Chest X-ray Data Using Modified MobileNetV2 and LIMEArticle Published on 2021-08-252022-10-31 Journal: International journal for equity in health [Category] COVID-19, [키워드] Accuracy Analysis approach AUC caused chest X-ray CNN Contagion Containment strategy contribute coronavirus COVID-19 COVID-19 patient COVID-19 patients CT scan dataset deep deep learning detection diagnosing Diagnosis driven by effective explain Explainable AI explanation feature global pandemic healthcare high accuracy imbalanced data initial Isolation mixed-data network Neural Novel coronavirus PCR Perspective polymerase chain Radiograph remained researcher Respiratory disease SARS-CoV-2 small data Spread supported the disease Transmission Vaccine widespread X-ray [DOI] 10.3390/healthcare9091099 PMC 바로가기 [Article Type] Article
Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodiesSARS-COV-2 스파이크 단백질에서의 시그니처 중화 항체로의 탈출Research Article Published on 2021-08-052022-08-13 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 binding ACE2 receptor Affect Alter Amino acid amino acid substitution amino acids Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies antibody Antibody neutralization binding Cell changes in circulating Combination convalescent core COVID-19 Critical Determining develop diagnostics E484K elicited engage enzyme evade Evolution explanation grid Host host immunity hotspot identify Immune escape immune escape mutants immune evasion in silico increase Infection Interaction K417N lentivirus MONITOR Mutation mutations N501Y Neutralizing antibodies neutralizing antibody neutralizing capacity Neutralizing-antibody Pandemics Protein provide provided pseudotyped lentiviruses Recognition reduce responses SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus SARS-CoV2 sera shown signature specificity Spike protein target targets tested the spike protein Therapies understanding vaccination Vaccine variants variants of concern Viral Viral protein virion virus [DOI] 10.1371/journal.ppat.1009772 PMC 바로가기 [Article Type] Research Article
Sudden shift to remote genetic counseling during the COVID-19 pandemic: Experiences of genetics professionals in ItalyCOVID-19 전염병 동안 원격 유전 상담으로의 갑작스러운 전환: 이탈리아 유전 전문가의 경험Article Published on 2021-08-012022-09-11 Journal: Journal of genetic counseling [Category] 유전자 메커니즘, [키워드] 2020 COVID-19 pandemic approach assessments clinic coded complex conducted coronavirus disease Coronavirus disease 2019 counseling COVID-19 demographics effective effective communication effort ENhance experience explanation Factor favor Genetic Genetic counseling genetics greater IMPROVE Infrastructure Italian Italy outcome pandemic participant physical professional promoted reflexive thematic analysis remote genetic counseling reported sudden Support Telemedicine telephone telephone genetic counseling. thematic analysis Travel visual aid visual aids [DOI] 10.1002/jgc4.1441 PMC 바로가기 [Article Type] Article
The renin-angiotensin system and specifically angiotensin-converting enzyme 2 as a potential therapeutic target in SARS-CoV-2 infectionsSARS-CoV-2 감염의 잠재적인 치료 표적으로서 레닌-안지오텐신 시스템 및 특히 안지오텐신 전환 효소 2Article Published on 2021-07-012022-09-11 Journal: Naunyn-Schmiedeberg's Archives of Pharmacology [Category] SARS, 치료제, [키워드] ACE-2 angiotensin angiotensin-converting enzyme 2 Cardiovascular function caused complex mechanism complex mechanisms country COVID-19 COVID-19 infection COVID-19 pandemic deaths entry receptor explanation hypothese modulation occurred pharmacological potential therapeutic target prevented preventive measure preventive measures protective role Protein RAS Regulation Renin renin-angiotensin system respiratory tract SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection Spread therapeutic intervention Therapeutic strategies vaccination Variation variations viral infection virus Wuhan Wuhan, China [DOI] 10.1007/s00210-021-02108-z PMC 바로가기 [Article Type] Article
Correlation of Low Levels of α -1 Antitrypsin and Elevation of Neutrophil to Lymphocyte Ratio with Higher Mortality in Severe COVID-19 Patients중증 COVID-19 환자에서 낮은 수준의 α-1 항트립신과 호중구 대 림프구 비율 상승과 사망률의 상관관계Observational Study Published on 2021-04-282022-09-10 Journal: Mediators of Inflammation [Category] MERS, SARS, 유전자 메커니즘, 임상, [키워드] accounted Admission alterations antitrypsin arterial oxygen saturation blood count blood sugar C-reactive protein CBC Chain Reaction cohort study Comorbidities complete blood count COVID-19 COVID-19 illness COVID-19 patient CRP CRP level CRP values dysregulated immune response dysregulation Elevation erythrocyte sedimentation erythrocyte sedimentation rate ESR etiology explanation form Glutamate groups Hospitalization hospitalized patient hospitalized patients hyperinflammation immune dysregulation immune response immunomodulatory effect individual Individual differences inflammation response involved Level lymphocyte marker mechanism mortality rate MOST neutrophil NLR not significantly different O2sat Observational cohort study Oxaloacetate oxygen oxygen saturation patients PCR percentage percentages plasma protein polymerase chain polymerase chain reaction positive COVID-19 Prevalence pyruvate random Ratio RBC Result retrospective sedimentation rate serum Serum level severe COVID-19 severe COVID-19 illness severe COVID-19 patient severe COVID-19 patients severe forms of COVID-19 severe symptoms severity SGOT SGPT sugar the patient troponin troponin level troponin levels with COVID-19 [DOI] 10.1155/2021/5555619 PMC 바로가기 [Article Type] Observational Study
Machine Learning Applied to Clinical Laboratory Data in Spain for COVID-19 Outcome Prediction: Model Development and ValidationOriginal Paper Published on 2021-04-142022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, MERS, SARS, [키워드] 95% CI Accuracy addition Additive Algorithm Analysis bootstrap C-reactive protein Care Classifier clinical Complication COVID-19 COVID-19 pandemic develop development Diagnosis died effective Electronic health record explanation extreme f-score feature Health help higher risk identify initial Laboratory Laboratory parameters lactate dehydrogenase machine learning Model Mortality neutrophil counts numbers of patient objective parameter Patient patients with COVID-19 predict prediction Predictive Receiver operator characteristic resource resources Result resulting risk selected sensitivity severe disease Severity of infection Spain specificity the disease treatment for COVID-19 urea validation was selected was used worse prognosis [DOI] 10.2196/26211 PMC 바로가기 [Article Type] Original Paper
Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity특발성 폐섬유증과 COVID-19 중증도 사이의 유전적 병인 공유Article Published on 2021-03-012022-09-11 Journal: EBioMedicine [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] airway airways Analysis association carriers causal variant characterized combined effect complex controls correlation COVID-19 COVID-19 hospitalization COVID-19 Host Genetics Initiative COVID-19 severity determine Effect estimate Evidence excluded explanation fibrosis foundation Genetic genetic association genetic determinant genetic etiology genetic risk factors genetic variants Genome-wide association study GWAS GWAS meta-analysis idiopathic Idiopathic pulmonary fibrosis increased risk initiative instrumental variable instrumental variables IPF Linkage disequilibrium lung Lung disease mendelian randomization MUC5B mucin Oak Older Older adults other variants outlier Patient performed Pneumonitis positive protective effect Protective effects provided pulmonary fibrosis risk allele risk factor risk loci risk of COVID-19 SARS-COV-2 infection scarring selection bia Selection bias Self-isolation severe COVID-19 severity survival susceptibility the strongest variance variant were used with COVID-19 [DOI] 10.1016/j.ebiom.2021.103277 PMC 바로가기 [Article Type] Article
Protein structural heterogeneity: A hypothesis for the basis of proteolytic recognition by the main protease of SARS-CoV and SARS-CoV-2단백질 구조 이질성: SARS-CoV 및 SARS-CoV-2의 주요 단백질 분해효소에 의한 단백질 분해 인식 기반에 대한 가설Article Published on 2021-03-012022-09-11 Journal: Biochimie [Category] SARS, 신약개발, 치료제, [키워드] active site Analysis antiviral drugs antiviral therapeutics appear binding binding site catalytically cleavage cleavage sites competent conformational Conformational selection conformations Drug development enzyme expand explain explanation flexibility Glutamine heterogeneity Hypothesis in viral independent independent of initial insight Ligand ligands M pro methionine modulation N- and C-termini observation observations property protease Protein proteolytic recognize recognizing Replication residue residues reveal SARS-CoV SARS-CoV-2 sequence specificity structural evidence Structure structures substrate substrates Variation viral protease viral replication [DOI] 10.1016/j.biochi.2021.01.010 PMC 바로가기 [Article Type] Article
COVID-19 and Pediatric Asthma: Clinical and Management ChallengesReview Published on 2021-01-262022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, [키워드] ACE2 expression activity Adults affected age airway allergic Antiviral approach Asthma Asymptomatic atopic atopy challenge childhood children clinical clinical impact conditions cough COVID-19 eosinophil Epidemic Evidence explanation focus Hypothesis IFN-α immunomodulatory include independent Infection Inhaled management medication obesity pediatric phenotype protective factor protective role raise reported risk risk factor risk stratification SARS-CoV-2 SARS-COV-2 infection severe SARS-CoV-2 Shortness of breath Spread Steroids Support Symptom Th2 the disease the SARS-CoV-2 Topic Treatment Vaccines vector wheezing [DOI] 10.3390/ijerph18031093 PMC 바로가기 [Article Type] Review