Explanation of hand, foot, and mouth disease cases in Japan using Google Trends before and during the COVID-19: infodemiology studyarticle Published on 2022-10-292024-09-02 Journal: BMC Infectious Diseases [Category] 대상포진, [키워드] explanation Google Trends HFMD Infection infodemiology [DOI] 10.1186/s12879-022-07790-9 PMC 바로가기 [Article Type] article
Theoretical Explanation for the Rarity of Antibody-Dependent Enhancement of Infection (ADE) in COVID-19Article Published on 2022-09-262022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] ADE antibody Antibody-dependent enhancement cell cultures Complete computational modeling computational modeling. Concentration condition COVID-19 determine effective enhancement explain explanation Human Infection lack Macrophage mathematical Occurrence Probability proportion SARS-CoV SARS-CoV-2 SARS-COV-2 infection seroconversion time Spread the SARS-CoV-2 virus vaccination Viral load [DOI] 10.3390/ijms231911364 PMC 바로가기
Viral immunogenic footprints conferring T cell cross-protection to SARS-CoV-2 and its variantsSARS-CoV-2 및 그 변이체에 T 세포 교차 보호를 부여하는 바이러스 면역원성 발자국Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] 229E 3D structure 3D Structures approach Asymptomatic case Asymptomatic cases CD8+ T cell cellular cellular response concern conserved contributing to Coronaviruses COVID-19 cross-protection cross-reactivity death disease Endemic epitope Epitopes examination expected explain explanation Features Genetic Heterologous HLA-A HLA-A*02:01 human coronaviruses human coronaviruses 229E human infection Immunity immuno informatics immunogenic immunogenic feature immunogenicity include indicate individual individuals infected individuals Infection involved molecular OC43 other coronaviruses outcomes pathogen Pathogens peptide peptides physicochemical Population SARS-CoV SARS-CoV-2 SARS-CoV-2 peptides SARS-CoV-2 sequence sequence Sequence analysis severe disease Structural analysis Structure T cell T-cell T-cell epitopes target Trigger uninfected Vaccine development variant variants virus viruses Wuhan [DOI] 10.3389/fimmu.2022.931372 PMC 바로가기 [Article Type] Article
Potential Autoimmunity Resulting from Molecular Mimicry between SARS-CoV-2 Spike and Human ProteinsSARS-CoV-2 스파이크와 인간 단백질 간의 분자 모방으로 인한 잠재적 자가면역Article Published on 2022-06-282022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adverse reactions AlphaFold2 antibody Antibody binding Asymptomatic Autoimmune Autoimmunity calcium cardiac disease cause coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 complication COVID-19 complications COVID-19 pathogenesis COVID-19 patients cross-reacting antibodies disease disorder Epitopes example explanation highlight host protein host proteins hotspot Human human proteins implication induce investigated involved machine learning mimicry molecular molecular dynamics molecular mimicry motif omicron outcomes platelet activation Potential PRKG1 Protein protein structure protein structure comparison reduce Regulation resulting SARS-CoV-2 SARS-CoV-2 spike spike Symptom therapeutic intervention therapeutic interventions thrombocytopenia Thrombopoietin tropomyosin Vaccine Vaccine design variant Viral Viral antigen viral antigens [DOI] 10.3390/v14071415 PMC 바로가기 [Article Type] Article
Severe Acute Respiratory Syndrome Coronavirus 2 ORF8 Protein Inhibits Type I Interferon Production by Targeting HSP90B1 Signaling중증 급성 호흡기 증후군 코로나바이러스 2 ORF8 단백질은 HSP90B1 신호 전달을 표적으로 하여 I형 인터페론 생산을 억제합니다Article Published on 2022-05-232022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Amino acid Antiviral caused coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 exhibit explanation function Genotype genotypes global pandemic high mutation rate high mutation rates HSP90B1 IFN-I IFN-β immune evasion Immune suppression implication individual induce inhibit inhibitory effect interact interferon interferon response investigated IRF3 ISG15 leucine MDA5 mechanism Mutation no difference nuclear translocation ORF8 ORF8 protein pandemic pathogenic pathway poly(I:C) Production Protein provide reported respiratory RIG-I SARS-CoV-2 Serine severe acute respiratory syndrome Coronavirus signaling pathway strain suppress targeting the SARS-CoV-2 Treatment Type type I interferon variant [DOI] 10.3389/fcimb.2022.899546 PMC 바로가기 [Article Type] Article
Discovery and Use of Long dsRNA Mediated RNA Interference to Stimulate Antiviral Protection in Interferon Competent Mammalian Cells인터페론 유능한 포유동물 세포에서 항바이러스 보호를 자극하기 위한 긴 dsRNA 매개 RNA 간섭의 발견 및 사용Article Published on 2022-05-062022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] Antiviral Antiviral effect antiviral response antiviral responses cell line cells cellular cleaved comparable competent complementary Concentration cornerstone CoV dependent on Dicer dsRNA Evidence explanation expressing fluorescent functional gene targeting generate green fluorescent protein HCoV HCoV-229E human coronavirus human coronaviruses IFN immune defense induce inducer inhibit Interference interferons knockdown Lineage Long long dsRNA mammalian mammalian cell mammalian cells Mediated mRNA pathway platform preventing infection produced protection Protein provide required responsible retained RISC RNA RNA interference RNA-induced silencing complex RNAi RNAi pathway SARS-CoV-2 replication sequence shown significantly siRNA siRNAs stimulate stomatitis suppress therapeutic These cells threshold type I interferon vesicular stomatitis vesicular stomatitis virus viral inhibition virus VSV-GFP [DOI] 10.3389/fimmu.2022.859749 PMC 바로가기 [Article Type] Article
Clinical and Laboratory Approach to Diagnose COVID-19 Using Machine LearningOriginal Research Article Published on 2022-02-082022-10-30 Journal: Interdisciplinary sciences, computational life sci [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Abstract acute respiratory syndrome Additive approach artificial intelligence automated Blood blood test blood tests calculate chain Classifier clinical clinician coronavirus 2 cough COVID-19 COVID-19 infection Critical CT scans dataset diagnose diagnosed Diagnosis emergency situation eosinophils explanation false-negative Health help IMPROVE Laboratory leukocyte machine learning machine-learning Monocytes new strain outbreak outcomes pandemic parameter patients Platelet positive result predict reaction RT-PCR RT-PCR test SARS-CoV-2 sensitivity synthetic technique virus were used [DOI] 10.1007/s12539-021-00499-4 PMC 바로가기 [Article Type] Original Research Article
Picturing Mental Health on Instagram: Insights from a Quantitative Study Using Different Content FormatsArticle Published on 2022-01-302022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] age boost changed comics conducted content convenience sampling COVID-19 cross-sectional Data collection evaluated explanation format help incidence individual influencer insight Instagram mental health mental health problems National offered participated per day Quantitative reported Research scored selected social distancing Social support Stress [DOI] 10.3390/ijerph19031608 PMC 바로가기 [Article Type] Article
Explainable Machine Learning for COVID-19 Pneumonia Classification With Texture-Based Features Extraction in Chest RadiographyDigital Health Published on 2022-01-172022-10-31 Journal: Frontiers in Digital Health [Category] COVID-19, [키워드] Accuracy Additive applied approach Chest chest X-ray Chest X-ray image classification coronavirus COVID-19 defined Diagnosis explainable models explanation extraction feature Features forest lung machine learning Non-COVID-19 Pneumonia Radiographic Radiography radiological radiological findings Radiomics random recursive feature elimination reverse transcription-PCR RT-PCR sensitivity SHAP x-rays zone [DOI] 10.3389/fdgth.2021.662343 PMC 바로가기 [Article Type] Digital Health
Impact of Lung Segmentation on the Diagnosis and Explanation of COVID-19 in Chest X-ray ImagesArticle Published on 2021-10-272022-10-29 Journal: Sensors (Basel, Switzerland) [Category] COVID-19, MERS, SARS, [키워드] artificial chest X-ray CNN COVID-19 creating CXR database diagnosed Dice evaluate Explainable artificial intelligence explanation Factor Image Impact inception intelligence introduced less lung Pneumonia provoke Radiation ROC Curve Segmentation Semantic segmentation Support was performed widespread X-ray [DOI] 10.3390/s21217116 PMC 바로가기 [Article Type] Article