SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster modelSARS-CoV-2 VOC 유형 및 생물학적 성별은 중증 COVID-19 드워프 햄스터 모델에서 몰누피라비르 효능에 영향을 미칩니다Article Published on 2022-07-292022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 임상, 치료기술, 치료법, 치료제, [키워드] Affect Antiviral benefit Cell disease effect size Efficacy evaluate females ferret ferrets hamster highest Human airway epithelium IMPROVE in vivo Infection inhibited lung Lung injury magnitude males management molnupiravir omicron oral organoids pathogenicity potency prevented reduced reduction in SARS-CoV-2 SARS-CoV-2 variants severe COVID-19 Sex survived Transmission Treatment effect size Trial triggered variants of concern virus load VoC [DOI] 10.1038/s41467-022-32045-1 PMC 바로가기 [Article Type] Article
Mutation L319Q in the PB1 Polymerase Subunit Improves Attenuation of a Candidate Live-Attenuated Influenza A Virus VaccineArticle Published on 2022-06-292023-06-14 Journal: Microbiology Spectrum [Category] Fulltext, 신종인플루엔자, [키워드] Attenuated cold-adapted ferrets guinea pigs influenza A virus live-attenuated influenza vaccines master donor virus protection efficacy temperature sensitive Transmission Vaccines [DOI] 10.1128/spectrum.00078-22 PMC 바로가기
Potency of Fusion-Inhibitory Lipopeptides against SARS-CoV-2 Variants of Concern우려되는 SARS-CoV-2 변이체에 대한 융합 억제 리포펩티드의 효능Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] affected antibodies antiviral efficacy Beta causative agent concern conformational conserved convalescent COVID-19 cross-protective described dimeric doses effective Efficacy elicited evade expected ferret ferrets FIVE Frequency fusion inhibitor Immunity in vitro in vivo Infection Intervention less lipopeptide mechanism of action monoclonal antibody monoclonal antibody therapy monomeric neutralize Neutralizing activity Neutralizing antibodies neutralizing antibody peptide peptides postvaccination postvaccine sera potency Protein Receptor binding Receptor-binding domain reported resulting S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 transmission SARS-CoV-2 variant selective selective pressure selective pressures sera Seven shown spike Spike protein Spread strain the receptor-binding domain therapeutic therapy vaccination Vaccine variant Viral viral entry viral evolution viral infection virus virus neutralization assays VoC VOCs Waves [DOI] 10.1128/mbio.01249-22 PMC 바로가기 [Article Type] Article
SARS CoV-2 (Delta Variant) Infection Kinetics and Immunopathogenesis in Domestic CatsSARS CoV-2(Delta Variant) 감염 역학 및 국내 고양이의 면역 병인 발생Article Published on 2022-06-012022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2-expressing cell ACE2-expressing cells acute COVID-19 acute infection animal model animal models B.1.617.2 chemokine chemokine signaling circulating Clinical sign Cluster correlated correlation COVID-19 disease COVID-19 disease course Critical cytokine receptor Delta delta variant develop differentially expressed gene Differentially expressed genes disease Disease progression disease transmission Divergence domestic cats dose downstream dysregulated evaluate feline ferrets flexible genetic modification help highlight Host hub genes identify immunopathology include Infection Infectious virus Inflammatory inflammatory pathways inoculated Interaction interactions intranasally Kinetics lesion lesions limitation lung lung tissue Lungs Mild nasal network analysis non-human primates pathology pathway peribronchial Pneumocytes Post-infection Prevent progression pulmonary inflammation pulmonary lesion pulmonary lesions Respiratory disease RNA sequencing SARS CoV SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants secretion significantly Spread target therapeutic timepoints transgenic mice translational upregulation variant Vascular endothelium Vasculitis Viral antigen Viral protein virus WGCNA wild-type SARS-CoV-2 [DOI] 10.3390/v14061207 PMC 바로가기 [Article Type] Article
Review of selected animal models for respiratory coronavirus infection and its application in drug researchReview Published on 2022-03-242022-10-04 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Analysis animal animal model animal models Characteristics Clinical features Clinical signs coronavirus Coronavirus infection Disadvantages disease drug Efficacy evaluate ferrets function hamsters Histopathology include Infection information limitations management mechanism mice New Novel coronavirus Numerous pathogen Pathogenesis reported Research Respiratory Coronavirus review SARS‐CoV‐2 SARS‐CoV‐2 selected Strains susceptible therapeutic drug Transmission Vaccines Viral pneumonia viral replication virus virus replication Wuhan [DOI] 10.1002/jmv.27718 PMC 바로가기 [Article Type] Review
Transmissibility and pathogenicity of SARS-CoV-2 variants in animal models동물 모델에서 SARS-CoV-2 변이체의 전염성 및 병원성Review Published on 2022-03-012022-09-11 Journal: Journal of microbiology (Seoul, Korea) [Category] SARS, 변종, 유전자 메커니즘, [키워드] accumulation animal model animal models choice Clinical studies Efficacy etiology evade evaluate ferrets hamsters high mortality rate Host immune response Immunity Impact knowledge limitation mechanisms mice Mutation non-human primates outbreak pandemic Pathogenesis pathogenicity Population public health threat Research researcher SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants SARSCoV-2 selection of variant selection of variants Spread therapeutic Therapeutics Topic Transmissibility Transmission Vaccine vaccine candidate vaccine candidates variant variants [DOI] 10.1007/s12275-022-2033-z PMC 바로가기 [Article Type] Review
Age-Related Susceptibility of Ferrets to SARS-CoV-2 InfectionSARS-CoV-2 감염에 대한 흰 족제비의 연령 관련 감수성Article Published on 2022-02-092022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affected age animal Cell coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated described differential expression dose expressed expressing Factors ferret ferrets ferrets. health condition higher infectivity humans individual individuals infectious dose Infectious virus inoculated intranasally nasal observation observations Older outcome platform replicate Replication respiratory SARS-CoV-2 SARS-COV-2 infection secretion Seroconversion severe acute respiratory syndrome Coronavirus shedding susceptibility tissues TMPRSS2 Transcription upper respiratory tract Viral viral entry viral replication virus virus entry [DOI] 10.1128/JVI.01455-21 PMC 바로가기 [Article Type] Article
Coinfection of Chickens with H9N2 and H7N9 Avian Influenza Viruses Leads to Emergence of Reassortant H9N9 Virus with Increased Fitness for Poultry and a Zoonotic PotentialArticle Published on 2022-01-122023-05-31 Journal: Journal of Virology [Category] Fulltext, 조류인플루엔자, [키워드] Avian influenza viruses Coinfection ferrets genetic reassortment H7N9 H9N2 H9N9 poultry virus transmission zoonosis [DOI] 10.1128/jvi.01856-21 PMC 바로가기
Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets흰 족제비에서 SARS-CoV-2 감염의 연령 의존적 병원성 특성Article Published on 2022-01-102022-09-12 Journal: Nature Communications [Category] SARS, 진단, 치료기술, [키워드] activated T cells age Characteristics clinical symptom Clinical symptoms Contact COVID-19 COVID-19 mortality COVID-19 patient COVID-19 patients COVID-19 severity direct contact ferret ferrets gene expression profile group groups healthy Human individuals infected with SARS-CoV-2 Infection inflammatory cell inflammatory cell infiltration interferon lung Macrophage macrophage responses manifestation mimicking nasal not differ Older Pathogenesis pathogenesis of SARS-CoV-2 pathogenic Patient reveal SARS-CoV-2 SARS-COV-2 infection Seroprevalence severe COVID-19 patients severe symptom severe symptoms severely infected patients significantly T cells Transcriptome transcriptome analysis transcriptomic profile Transmission type I interferon Viral host response viral loads Viral transmission virus while [DOI] 10.1038/s41467-021-27717-3 PMC 바로가기 [Article Type] Article
COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal modelsSARS-CoV-2 RBD를 암호화하는 전기천공 DNA 백신 후보인 COVID-eVax는 동물 모델에서 보호 반응을 이끌어냅니다.Article Published on 2022-01-052022-09-11 Journal: Molecular therapy : the journal of the American So [Category] SARS, 변종, 진단, [키워드] animal model animal models anti-SARS-CoV-2 Antiviral antiviral immunity approved Brain caused cDNA clinical development COVID-19 COVID-19 pandemic COVID-19 vaccine Critical DNA DNA plasmid DNA vaccine domain effective vaccine Electroporation elicit European expressing ferret ferrets form hACE2 identify immunized K18-hACE2 transgenic mice lung Lungs monomeric Neutralizing antibody response neutralizing antibody responses profile protection protective response Protein Pulmonary function RBD reduced robust Safe SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike secreted Skeletal muscle T cell T cell response the SARS-CoV-2 Trial Vaccine vaccine platform variants of concern Viral Viral antigen viral replication weight loss [DOI] 10.1016/j.ymthe.2021.09.011 PMC 바로가기 [Article Type] Article