Combined administration of inhaled DNase, baricitinib and tocilizumab as rescue treatment in COVID-19 patients with severe respiratory failure중증 호흡부전이 있는 COVID-19 환자의 구조 치료로서 흡입형 DNase, 바리시티닙 및 토실리주맙의 병용 투여Article Published on 2022-05-012022-09-12 Journal: Clinical immunology (Orlando, Fla.) [Category] Coronavirus, COVID19(2023년), SARS, 바이오마커, 임상, 진단, 치료법, [키워드] Administered administration analysed Baricitinib clinical observations Combined COVID-19 COVID-19 patient dissolve DNase duration of hospitalization fibroblasts Follow-up group hyperinflammation IL-1-receptor Immunomodulatory agent immunothrombosis in-hospital mortality Inhaled inhibited inhibitor intubation rate lung median monotherapy Neutrophil extracellular traps paO2/fiO2 pathway plasma randomized trial reduce mortality severe respiratory failure significantly Standard-of-care Support survival tissue Tissue Factor Tocilizumab Treatment [DOI] 10.1016/j.clim.2022.109016 PMC 바로가기 [Article Type] Article
Potential of Ferritin-Based Platforms for Tumor Immunotherapy종양 면역 요법을 위한 페리틴 기반 플랫폼의 잠재력Review Published on 2022-04-222022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 변종, [키워드] addition animal models antioxidant cellular clinical trials coronavirus dendritic dendritic cells described draining lymph nodes drug drugs Efficacy encapsulate expected ferritin fibroblasts functions greater immune immunomodulator Immunotherapy iron iron homeostasis Lymph node M2 tumor-associated macrophages macrophages mechanism Modification On the Road overcome penetration Phase I platform Potential PROTECT Protein Research road subunits tissue transformation Tumor tumor cells Tumor vaccine tumor-associated fibroblasts. tumor-associated macrophages unique Vaccine variants of SARS-CoV-2 [DOI] 10.3390/molecules27092716 PMC 바로가기 [Article Type] Review
The therapeutic potential of regulatory T cells in reducing cardiovascular complications in patients with severe COVID-19Review article Published on 2022-04-012022-10-05 Journal: Life sciences [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 Affect cardiac damage cardiovascular cardiovascular complication cardiovascular complications Cardiovascular function cause Cell cells cellular chemokine Comorbidity contribute coronavirus COVID-19 COVID-19 pathogenesis COVID-19 patients Cytokine storm disorder evaluated expressed fibroblasts function immune Immune cell immunological mechanism IMPROVE infect Inflammation Inflammatory cytokine Inflammatory responses macrophages mechanism mechanisms molecular Monocytes Patient pericytes reducing regulate Regulatory T cell Research risk SARS Coronavirus SARS CoV-2 severe COVID-19 subset suppress T cell target cell therapeutic potential These cells Treatment Treg Tregs variety viral infection [DOI] 10.1016/j.lfs.2022.120392 [Article Type] Review article
Epigenetic Changes and Functions in PneumoconiosisReview Article Published on 2022-01-202022-10-29 Journal: Oxidative Medicine and Cellular Longevity [Category] Coronavirus, [키워드] accompanied alveolar epithelial cells Cell change changes characterized Clarifying coronavirus disease disease DNA methylation epidemiological Epigenetic Evidence Extracellular matrix Factor fibroblasts fibrosis function in vitro experiments in vivo inhibit Lung disease lung tissue macrophages noncoding RNA Occurrence Pathogenesis pneumoconiosis promote pulmonary pulmonary fibrosis specific treatment therapeutic target Treatment turn [DOI] 10.1155/2022/2523066 PMC 바로가기 [Article Type] Review Article
Overexpression of the SARS-CoV-2 receptor angiotensin converting enzyme 2 in cardiomyocytes of failing heartsArticle Published on 2022-01-192022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] ACE2 ACE2 expression ACE2 receptor Biochemistry Biomarkers Biotechnology Cardiology cardiovascular comorbidity Cell Biology dependent on disease Diseases Donor Endothelial cell endothelial cells enzyme expressed expression fibroblast fibroblasts healthy donor heart heart failure hearts immunohistochemistry immunology in both groups infect cells Medical research Molecular biology Molecular medicine myocarditis organ outcome Patient Physiology proteomics Quantitative receptor risk RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus subpopulation the SARS-CoV-2 tissue ventricular was measured was used [DOI] 10.1038/s41598-022-04956-y PMC 바로가기 [Article Type] Article
Hydroxychloroquine treatment on SARS-CoV-2 receptor ACE2, TMPRSS2 and NRP1 expression in human primary pterygium and conjunctival cells인간의 일차 익상편 및 결막 세포에서 SARS-CoV-2 수용체 ACE2, TMPRSS2 및 NRP1 발현에 대한 히드록시클로로퀸 치료Multicenter Study Published on 2022-01-012022-09-11 Journal: Experimental eye research [Category] SARS, 바이오마커, [키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 applied binding Cell cell viability cells Combination concentration of hydroxychloroquine Conjunctiva conjunctival coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment decrease elevated enzyme epithelial evaluate expression fibroblasts host cell host cell receptor Hydroxychloroquine hydroxychloroquine treatment increase in Infection influences neuropilin Neuropilin-1 NRP1 oxidative stress pandemic pathogen Protein protein expression Pterygium reduced reduction respiratory ROS production SARS-CoV-2 SARS-CoV-2 receptor Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Side effect significantly SOD2 Spike protein tissue TMPRSS2 TMPRSS2 expression TMPRSS2 inhibitor TMPRSS2 protein transmembrane serine protease Treatment Treatment strategies type II transmembrane serine protease viability [DOI] 10.1016/j.exer.2021.108864 PMC 바로가기 [Article Type] Multicenter Study
Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells Research Published on 2021-12-302022-10-05 Journal: Nature cell biology [Category] 바이오마커, 유전자 메커니즘, [키워드] accumulate alveolar Analysis Basal cell Cell co-culture described driven by ectopic fibroblast fibroblasts growth histologic Human human lung in vitro in vivo indicate indicated Injury IPF Lineage Loss lung metaplastic morphogenic murine Organoid pathologic promoted Protein pulmonary fibrosis severe lung injury single-cell analysis trajectory Transforming [DOI] 10.1038/s41556-021-00809-4 [Article Type] Research
Skin Aging, Cellular Senescence and Natural PolyphenolsReview Published on 2021-11-232022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] accumulate affecting age anti-senescence carried Cell cellular senescence change contribute COVID-19 pandemic Effect fibroblasts Health in vitro study knowledge mechanism Melanocyte molecular morphology natural natural polyphenols organ Pathologies pathology pathway polyphenol Prevent senescence skin aging [DOI] 10.3390/ijms222312641 PMC 바로가기 [Article Type] Review
Calcineurin-nuclear factor for activated T cells (NFAT) signaling in pathophysiology of wound healingReview Published on 2021-08-182022-10-30 Journal: Inflammation and Regeneration [Category] COVID-19, [키워드] activated T cell activation pathway Angiogenesis Calcium signaling cells Coagulation Critical disease Diseases dysregulated dysregulation endothelial cells fibroblasts fibrosis Final form future therapeutic homeostasis Immune cell immune cells Inflammation microenvironment multiple organ NFAT occurred pathophysiology physical regulate Signaling wound wound healing [DOI] 10.1186/s41232-021-00176-5 PMC 바로가기 [Article Type] Review
Unfolded Protein Response Inhibition Reduces Middle East Respiratory Syndrome Coronavirus-Induced Acute Lung InjuryResearch Article Published on 2021-08-102022-10-29 Journal: mBio [Category] COVID-19, MERS, [키워드] acute lung injury alleviate Analysis Apoptosis approved Cell culture contribute coronavirus Critical Cytopathic effect data set demonstrated disease Endothelial cell expression pattern fibroblast fibroblasts functional enrichment HAE Host host response human airway epithelial human lung individuals inhibition Interaction Intervention kinetic lung lung cell Lung disease male mechanism MERS-CoV MERS-CoV infection mice microvascular endothelial cells Middle East Outbreaks outcomes pathway patients Pharmacologic primary human lung cells progression Protein proteomes provide reduced reductions in regulated replicate replication kinetics respiratory Respiratory function respiratory syndrome coronavirus response Stress Symptom System tissue transcript transcriptomes unfolded protein response UPR validation study viability viral titer virus infection weight loss were infected [DOI] 10.1128/mBio.01572-21 PMC 바로가기 [Article Type] Research Article