A transferable deep learning approach to fast screen potential antiviral drugs against SARS-CoV-2SARS-COV-2에 대한 빠른 스크린 잠재적 항 바이러스 약물에 대한 양도 가능한 딥 러닝 접근Article Published on 2021-11-052022-08-31 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 신약개발, 치료제, [키워드] accelerate anti-SARS-CoV-2 antiviral drug applied approach approach binding build can be used cause Compound coronavirus COVID-19 COVID-19 pandemic database deep learning demonstrated disease Docking studies docking study drug candidate drug candidates Drug discovery Drug repurposing effective enzyme FDA-approved drug FDA-approved drugs fine-tune inhibit list proof protease reported SARS-CoV-2 Seven tested transfer Treatment Virtual screening virtual screening. [DOI] 10.1093/bib/bbab211 PMC 바로가기 [Article Type] Article
Induction of trained immunity by influenza vaccination – impact on COVID-19인플루엔자 예방접종을 통한 훈련된 면역 유도 - 코로나19에 미치는 영향Observational Study Published on 2021-10-252022-09-10 Journal: PLoS Pathogens [Category] MERS, 유전자 메커니즘, 임상, [키워드] affected anti-SARS-CoV-2 assays caused claimed COVID-19 COVID-19 incidence COVID-19 vaccine cross-protection decrease distribution Effects epidemiological Epidemiological study fine-tune flu healthcare worker help hospital identify Immune cell immune cells immune responses Immunity immunological inactivated induction Influenza influenza vaccination influenza vaccine innate immune response innate immune responses Innate immunity investigated less lower risk mechanism mind monocyte Monocytes observation pandemic potential benefit potential benefits protective effect proteomics randomized trial reduced Relative risk reported reveal risk reduction Safe SARS-CoV-2 SARS-COV-2 infection Seasonal influenza Single-cell RNA sequencing suggested systemic inflammation transcriptional vaccination vaccination against COVID-19 Vaccine variant Viral virus [DOI] 10.1371/journal.ppat.1009928 PMC 바로가기 [Article Type] Observational Study
Evaluating Deep Neural Network Architectures with Transfer Learning for Pneumonitis DiagnosisResearch Article Published on 2021-09-122022-10-31 Journal: Computational and Mathematical Methods in Medicine [Category] Coronavirus, MERS, SARS, [키워드] Activation alleviate Analysis architecture AUROC cause chest X-ray Chest X-ray images dataset deep deep learning Deep Learning Method detection Diagnosis Early detection evaluate Evaluating fine-tune help Infectious disease Inflammation Kaggle knowledge learning life-threatening network Neural outperform Pneumonitis Predictive recall recent significantly transfer was used X-ray [DOI] 10.1155/2021/8036304 PMC 바로가기 [Article Type] Research Article
Ivermectin for Prophylaxis and Treatment of COVID-19: A Systematic Review and Meta-AnalysisSystematic Review Published on 2021-09-082022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] 95% CIs 95% confidence interval Admission adverse event Analysis baseline benefit CIs Clinical efficacy clinical trial registry Control control group COVID-19 decreased mortality Disease progression Evidence fine-tune Guidance include indicated indication intensive care Ivermectin likelihood mechanical ventilation Meta-analysis methodology Mild moderate disease Mortality negative RT-PCR no difference outcome Participants Patient patients Potential treatment Prophylaxis RCT recipient reported Repository review risk Risk of bias SARS-CoV-2 searched severe disease severe pneumonia significantly subjects Support systematic review Treatment treatment for COVID-19 Treatment protocol was used [DOI] 10.3390/diagnostics11091645 PMC 바로가기 [Article Type] Systematic Review
Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection차등 혈장 세포질 수지상 세포 표현형 및 무증상 및 심한 COVID-19 감염에서 I 형 인터페론 반응Research Article Published on 2021-09-022022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, SARS, 유전자 메커니즘, [키워드] absence accompanied adaptive immune responses Anti-viral anti-viral IFN anti-viral response antiviral responses Asymptomatic asymptomatic SARS-CoV-2 infected subjects Cell cells cellular characterized chemokine chemokines circulating contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient Critically ill Critically ill patient critically ill patients cytokine Cytokine storm Cytokines death Defense dendritic cell dendritic cells disease severity early phase elevated ENhance epithelial cells event Evidence Ex vivo expression fine-tune Frequency hospitalized patient hospitalized patients Host host defense Host-directed therapies host-directed therapy human peripheral blood mononuclear cell IFN IFN-stimulated gene Immune cell immune cells immune responses Immunity IMPROVE in vitro induce Infection Inflammatory cytokine Inflammatory cytokines inflammatory phenotype inhibiting viral replication Innate innate immune response Innate immunity Interaction interferon interferons investigated low frequency Lung epithelial cells mechanism mononuclear cell multi-organ failure neuropilin observation Pathogenesis PBMC PD-L1 marker pDC/type I IFN axis Peripheral blood pharmacological strategy phenotype plasmacytoid dendritic cell plasmacytoid dendritic cells pro-inflammatory cytokine pro-inflammatory cytokines producing productive viral replication progression protective role regulate Regulation released responsible resulting SARS-CoV-2 SARS-CoV-2 infected subject SARS-COV-2 infection SARS-CoV-2 pandemic secreted secretion serum severe COVID-19 Severe COVID-19 Infection severe COVID-19 patients stratified the cytokine storm the interferon tissue damage TLR7/8 type I type I and III IFNs type I and III interferons Type I IFN type I IFN producing cells Viral viral replication Viral resistance virus viruses [DOI] 10.1371/journal.ppat.1009878 PMC 바로가기 [Article Type] Research Article
Learning-to-augment strategy using noisy and denoised data: Improving generalizability of deep CNN for the detection of COVID-19 in X-ray images노이즈 및 노이즈 제거 데이터를 사용한 학습-증강 전략: X선 이미지에서 COVID-19 감지를 위한 심층 CNN의 일반화 개선Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 변종, 치료기술, [키워드] approach Bayesian chest X-ray Chest X-ray images classification CNN COVID-19 data augmentation database deep deep learning develop distance fine-tune Generalizability generalization generate healthy IMPROVE Improving Learning-to-augment Noise parameters pneumonia cases positive robustness sensitivity source code specificity variant X-ray X-ray images. [DOI] 10.1016/j.compbiomed.2021.104704 PMC 바로가기 [Article Type] Article
Implementation of an open-source robotic platform for SARS-CoV-2 testing by real-time RT-PCRResearch Article Published on 2021-07-142022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] automated bioinformatics Care changes clinical care complex dependent on diagnostics European evaluated experimental protocols fine-tune global pandemic Health health system hospital include increase in International Laboratory limit network platform protocol protocols Quality real time real-time RT-PCR RT-PCR SARS-CoV-2 PCR testing SARS-CoV-2 testing Supply chain the SARS-CoV-2 [DOI] 10.1371/journal.pone.0252509 PMC 바로가기 [Article Type] Research Article
Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble MediatorsReview Published on 2021-06-292022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] absence Adaptive immune response cause chemokine COVID-19 COVID-19 disease severity COVID-19 pandemic COVID-19 patients Cytokines described disease severity excessive inflammatory response fine-tune host antiviral response immune response immunological Immunopathogenesis indicate individual Infection Innate Innate immune cells innate immune response Innate immunity mediator naïve outcome phenotype pre-existing immunity Protective provide researcher response SARS-CoV-2 SARS-COV-2 infection soluble and cellular mediators subject tissue tropism Transmissibility unique vaccinees virus [DOI] 10.3390/ijms22137017 PMC 바로가기 [Article Type] Review
CORONA-Net: Diagnosing COVID-19 from X-ray Images Using Re-Initialization and Classification NetworksArticle Published on 2021-04-282022-10-30 Journal: ISA transactions [Category] COVID-19, [키워드] Accuracy automated backbone Chest X-ray image Chest X-ray images classification CNNs combating CORONA-Net COVID-19 COVID-19 pandemic COVIDx dataset deep learning detect distribution experiment Extensive fine-tune Health help Image network Neural outbreak outperform pandemic performed radiologist significantly the disease X-ray [DOI] 10.3390/jimaging7050081 PMC 바로가기 [Article Type] Article
Deep Transfer Learning Approach for Automatic Recognition of Drug Toxicity and Inhibition of SARS-CoV-2Article Published on 2021-04-022022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] accelerate acute respiratory syndrome Antiviral antiviral drug approach Automatic cause cell death Chloroquine Concentration Coronavirus-2 COVID-19 CPE Cytopathic effect deep deep learning Deep transfer learning drug Drug screening drugs DTL Emetine fine-tune Hydroxychloroquine Image implementation in vitro experiments include inhibition inhibitory effect learning Microscopy monolayer pandemic provided quantification Recognition Remdesivir responsible SARS-CoV-2 Screening TOX Toxicity transfer virus titer viruses [DOI] 10.3390/v13040610 PMC 바로가기 [Article Type] Article