Disinfection of otorhinolaryngological endoscopes with electrolyzed acid water: A cross-sectional and multicenter studyArticle Published on 2022-10-032022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome Bacteria Bacterial bacterial specy clinically Contact Contamination contributing to coronavirus coronavirus disease Corynebacterium cross-sectional Culture Detection limit determine Disinfection Efficacy examined flexible germicide glutaraldehyde humans hygiene in vitro in vitro study inactivation infection control initial investigated less multicenter pandemic reduced safety profile SARS-CoV-2 Staphylococcus strain tested treated viral titer virus Volume [DOI] 10.1371/journal.pone.0275488 PMC 바로가기
A highly powerful nonspecific strategy to reduce COVID-19 deathsCOVID-19 사망자를 줄이기 위한 매우 강력한 비특이적 전략Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antiviral antiviral therapy Case fatality rate caused Co-infection coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case death deaths disease Diseases Disinfection fatality Fatality rate feasible flexible function Good Health Health Behavior IMPROVE Infectious diseases Isolation less maintain maintenance Mild nonspecific pandemic Pandemics pathogenic reduce SARS-CoV-2 severe acute respiratory syndrome Coronavirus Strategy supported Symptom to some degree Treatment Vaccines [DOI] 10.1002/jmv.27949 PMC 바로가기 [Article Type] Article
Are the Current Processes and Regulations Fit for Purpose to Deliver Novel Therapies During Pandemics? A Perspective on COVID-19 from the UKArticle Published on 2022-10-012022-11-16 Journal: Pharmaceutical medicine [Category] 신약개발, [키워드] activities adaptive approval arise contribute country COVID-19 COVID-19 pandemic current develop Dexamethasone ENhance flexible Health involved lesson Medicines multi-arm novel Pandemics question rare diseases RECOVERY trial reduce Regulation Regulatory regulatory pathways shown Stress therapy Trial trials UK Medicine United Kingdom urgency [DOI] 10.1007/s40290-022-00439-7 PMC 바로가기
Global impact of the COVID-19 pandemic on mental health services: A systematic reviewReview article Published on 2022-10-012022-10-05 Journal: Journal of psychiatric research [Category] 진단, [키워드] Admission change changes in Community Community psychiatry conducted coronavirus country COVID-19 COVID-19 pandemic COVID-19 patients database diagnostic Effect finding FIVE flexible groups hospital Impact infection control lack measure Measures medication mental health mental health service mental health services National nine offered pandemic Patient populations Psychiatric Quantitative reduced staff Support systematic review telepsychiatry therapeutic while [DOI] 10.1016/j.jpsychires.2022.08.013 [Article Type] Review article
Suppression of SARS-CoV-2 Replication with Stabilized and Click-Chemistry Modified siRNAsArticle Published on 2022-09-192022-11-15 Journal: Angewandte Chemie (International ed. in English) [Category] SARS, 변종, 치료제, [키워드] Antiviral antiviral activity Antiviral compounds antiviral medication Apoptosis cell line Corona Corona pandemic cytotoxicity facilitate FIVE flexible Ligand lung magnitude mutations peptide peptide RNA conjugates receptor reduce RNA SARS-CoV-2 sequence siRNA suppression variants of concern variants of SARS-CoV-2 viral escape Viral load virus replication [DOI] 10.1002/anie.202204556 PMC 바로가기
Screening and Characterization of Shark-Derived VNARs against SARS-CoV-2 Spike RBD ProteinArticle Published on 2022-09-182022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] ACE2 addition affinity angiotensin-converting enzyme 2 antibodies antibody fragment Antibody therapeutics Antigen bi-paratopic VNAR binding binding affinities characterization classical complexes COVID-19 Delta domain epitope exhibited FIVE flexible fusing fusion gel filtration immunized inaccessible motif omicron Protein RBD RBD binding receptor recognize reported SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD Screening shark spike Spike protein the RBD the SARS-CoV-2 variants VNAR wildtype [DOI] 10.3390/ijms231810904 PMC 바로가기
Policy-driven mathematical modeling for COVID-19 pandemic response in the PhilippinesResearch article Published on 2022-09-012022-10-05 Journal: Epidemics [Category] 치료기술, [키워드] Analysis applied approach Community compartmental model contributed correlated COVID-19 COVID-19 pandemic data-driven disease Disease surveillance effort epidemiological flexible Government Healthcare system implementation improvement mathematical Model National outcome pandemic Philippines platform Policy predict public health quarantine question response spread of COVID-19 Stage subsequent toolkit trajectory [DOI] 10.1016/j.epidem.2022.100599 [Article Type] Research article
Development of a simple genotyping method based on indel mutations to rapidly screen SARS-CoV-2 circulating variants: Delta, Omicron BA.1 and BA.2SARS-CoV-2 순환 변이체: Delta, Omicron BA.1 및 BA.2를 신속하게 스크리닝하기 위한 indel 돌연변이에 기반한 간단한 유전형 분석법 개발Article Published on 2022-09-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Analytical specificity circulating circulating SARS-CoV-2 variants concern Concordance COVID-19 case Delta Delta VOC develop development facilitate flexible genotyping identify implementation melting curve analysis Mutation mutations omicron Partial partial sequencing performed primer public health qPCR assay qPCR assays S gene SARS-CoV-2 Screening screening method Sequencing verification VOCs [DOI] 10.1016/j.jviromet.2022.114570 PMC 바로가기 [Article Type] Article
Design and Analysis of Studies Based on Hierarchical Composite Endpoints: Insights from the DARE-19 Trial계층적 복합 종점을 기반으로 한 연구의 설계 및 분석: DARE-19 시험의 통찰력Article Published on 2022-09-012022-09-11 Journal: Therapeutic innovation & regulatory science [Category] 임상, [키워드] accompanied Analysis analyzed cardiometabolic Cardiometabolic risk factors clinical endpoint Clinical endpoints Clinical outcome clinical outcomes clinically component components Composite composite endpoint COVID-19 COVID-19 pneumonia Dapagliflozin described detectable disease Effect Endpoint example flexible handling Hierarchical composite endpoints hospitalized patient hospitalized patients ICH include inhibitor insight Interpretation mechanism mechanism of action Missing data offered Pneumonia power primary endpoints randomized trial ranking Sample size SGLT2 inhibitors statistical suggested the primary endpoint therapeutic to define Treatment Trial Win odds. with COVID-19 [DOI] 10.1007/s43441-022-00420-1 PMC 바로가기 [Article Type] Article
Exploring the risk factors of COVID-19 Delta variant in the United States based on Bayesian spatio-temporal analysisArticle Published on 2022-09-012022-11-16 Journal: Transboundary and emerging diseases [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis Bayesian Bayesian analysis Cluster coefficient collected contagious contribute coronavirus covariate COVID-19 COVID-19 variant cases delta variant develop Effect Epidemic Factor flexible genetic mutation Government group help heterogeneity Hierarchical identify independent variables measure Region risk factor Risk factors SARS-CoV-2 selected space-time model spatial clusters Spread statistical the United State Transmission variable selection variant worsened [DOI] 10.1111/tbed.14623 PMC 바로가기