Utility of Newborn Dried Blood Spots to Ascertain Seroprevalence of SARS-CoV-2 Antibodies Among Individuals Giving Birth in New York State, November 2019 to November 20212019년 11월부터 2021년 11월까지 뉴욕주에서 출생한 개인들 사이에서 SARS-CoV-2 항체의 혈청유병성을 확인하기 위한 신생아 건조 혈액 반점의 유용성Article Published on 2022-08-012022-09-11 Journal: JAMA Network Open [Category] SARS, 진단, 치료기술, [키워드] 95% CI age analyzed association Birth Birth weight Blood can be used Characteristics collected conducted correlated COVID-19 COVID-19 case COVID-19 vaccination cross-sectional cross-sectional study cumulative DBS sample detect Dried blood spots exposure to female fluctuation gestational age Giving identify IgG antibodies IgG antibody immunoassay individual individuals Infant Infants Low birth weight Lower male maternal age median microsphere MONITOR Multiple birth New York Newborn Odds ratio Older outcome pregnant Prevalence Program reflected repeated reported S antigen SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 N SARS-CoV-2 nucleocapsid SARS-CoV-2 seroprevalence Screening screening program Seroprevalence Serosurvey Serosurveys significantly lower spot state stratified study period submitted utility vaccination Vaccinations was measured women [DOI] 10.1001/jamanetworkopen.2022.27995 PMC 바로가기 [Article Type] Article
Global slowness and increased intra-individual variability are key features of attentional deficits and cognitive fluctuations in post COVID-19 patients Research Published on 2022-07-302022-10-05 Journal: Scientific Reports [Category] 임상, 치료기술, 치료법, [키워드] Analysis ANOVA assessment assessments Attention cognitive collected components Control controls cortical COVID-19 COVID-19 neurological symptoms COVID-19 patient disorder distribution enrolled executive explain fatigue feature fluctuation hallmark healthy volunteer impairment intra-individual measure mechanism Montreal motor Neurological involvement Patient patients reaction resting RTS significant interaction significantly higher sustained Symptom syndrome time to define Variability [DOI] 10.1038/s41598-022-17463-x [Article Type] Research
Integrating Conformational Dynamics and Perturbation-Based Network Modeling for Mutational Profiling of Binding and Allostery in the SARS-CoV-2 Spike Variant Complexes with Antibodies: Balancing Local and Global Determinants of Mutational Escape Mechanisms항체가 있는 SARS-CoV-2 스파이크 변이체 복합체에서 결합 및 알로스테리의 돌연변이 프로파일링을 위한 형태 역학 및 섭동 기반 네트워크 모델링 통합: 돌연변이 탈출 메커니즘의 로컬 및 글로벌 결정인자 균형 조정Article Published on 2022-07-102022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Affect allosteric communication Analysis antibodies antibody Antibody binding antibody combination antibody escape approach balancing binding binding affinity binding energy binding hotspots binding interaction change complexes conformational conformational dynamics conserved cross-reactive determinant determined by dominant dynamic network modeling Dynamics Effect Efficiency energetics escape escape mutant escape mutants Factors flexibility fluctuation host receptor identify Interaction interactions Local MD simulations mechanism modeling modulate Mutation mutational profiling mutations network neutralization neutralize omicron pattern predict Profiling Protein protein folding protein stability residue SARS-CoV-2 spike SARS-CoV-2 spike protein single antibody spike spike plasticity Spike protein stability suggested the antibody the SARS-CoV-2 ultrapotent antibodies. variant [DOI] 10.3390/biom12070964 PMC 바로가기 [Article Type] Article
Anti-IFN-α/-ω neutralizing antibodies from COVID-19 patients correlate with downregulation of IFN response and laboratory biomarkers of disease severityCOVID-19 환자의 항-IFN-α/-ω 중화 항체는 IFN 반응의 하향조절 및 질병 중증도의 실험실 바이오마커와 상관관계가 있습니다Article Published on 2022-07-012022-09-11 Journal: European Journal of Immunology [Category] MERS, 바이오마커, 진단, 치료기술, [키워드] Antiviral association autoantibodies autoantibodies, SARS-CoV-2 binding binding antibodies binding antibody biochemical characterized COVID-19 COVID-19 patient cross-reactivity CRP D-dimer dimer disease severity downregulation fluctuation Gene Expression hematological parameters ICU IFN IFN response IFN-stimulated gene IFN-stimulated genes IFN-α interferon ISG ISGs laboratory biomarker laboratory biomarkers LDH male Neutralizing antibodies neutralizing antibody outcome Patient patients positive positive patient proportion quantified reduced respiratory Respiratory samples screened sera serum severe COVID-19 shown specificity subset tested transcript levels [DOI] 10.1002/eji.202249824 PMC 바로가기 [Article Type] Article
Spatial and temporal fluctuations in COVID-19 fatality rates in Brazilian hospitals브라질 병원의 COVID-19 사망률의 공간적 및 시간적 변동Article Published on 2022-07-012022-09-11 Journal: Nature Medicine [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Bayesian Brazil caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical death died Fatality rate fluctuation Gamma healthcare hospital Hospitalization hospitalized patient hospitalized patients In-hospital Infection morbidity Mortality Older pandemic pathogen Pathogens Patient resources SARS-CoV-2 severe acute respiratory syndrome Coronavirus Shock Spread variant [DOI] 10.1038/s41591-022-01807-1 PMC 바로가기 [Article Type] Article
Omicron variant receptor-binding domain phylogenetics and molecular dynamics오미크론 변이체 수용체 결합 도메인 계통발생학 및 분자 역학Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] addition Alpha alpha and delta variants Amino acid analyses angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 receptor anticipated antigenic antigenic epitope antigenic epitopes antigenic site arithmetic mean Beta binding changes in Clustering conformation conserved COVID-19 Delta deviation domain epitope Epitopes evolutionary relationships expected FIVE fluctuation Gamma greater immune reactions investigated MD simulations molecular molecular dynamics Mutation mutations omicron Omicron variant other variants Phylogenetic Phylogenetic relationship phylogenetics predicted RBD RBD binding RBD mutation RBD of SARS-CoV-2 receptor Receptor-binding domain residue residues Root-mean-square deviation SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant SARS-CoV-2 variants sequence significantly suggested surface area tested the receptor-binding domain the SARS-CoV-2 variant variants [DOI] 10.1016/j.compbiomed.2022.105633 PMC 바로가기 [Article Type] Article
Sars-Cov-2 Spike Protein-Induced Damage of hiPSC-Derived CardiomyocytesSars-Cov-2 스파이크 단백질에 의한 hiPSC 유래 심근세포 손상Article Published on 2022-07-012022-09-12 Journal: Advanced Biology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 alteration Ang II angiotensin-converting enzyme 2 Cardiomyocytes chromatin cleavage complex connexin Culture damage downregulated Effect endocytic expression fluctuation functional hiPSC host cells incubated investigated margination molecular pluripotent stem cell Protein Proteins receptor SARS-CoV-2 spike Spike protein Spike proteins Structure subunit the spike protein undergo virus while [DOI] 10.1002/adbi.202101327 PMC 바로가기 [Article Type] Article
Peptide Binder with High-Affinity for the SARS-CoV-2 Spike Receptor-Binding DomainSARS-CoV-2 스파이크 수용체 결합 도메인에 대한 고친화성을 갖는 펩티드 결합제Article Published on 2022-06-292022-09-11 Journal: ACS applied materials & interfaces [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity peptide albumin antigen detection assembly binder binding binding affinity Biomarker Biomarkers bovine bovine serum albumin Characteristics coronavirus Delta diagnostics dissociation Dissociation constant early diagnosis exhibited fluctuation Gamma gold Gold nanoparticle high affinity Human serum albumin identify independent Interaction interface Lambda mutant omicron Omicron variants peptide phage Rapid rapid detection method RBD Receptor-binding domain recombinants respiratory SARS-CoV-2 SARS-CoV-2 spike protein selectivity sensor sequence serum albumin severe acute respiratory syndrome Coronavirus spike Spike protein the binding affinity the RBD the receptor-binding domain the SARS-CoV-2 variants [DOI] 10.1021/acsami.2c03707 PMC 바로가기 [Article Type] Article
A one-year follow-up study on dynamic changes of leukocyte subsets and virus-specific antibodies of patients with COVID-19 in Sichuan, China중국 쓰촨성 코로나19 환자의 백혈구 하위 집합 및 바이러스 특이 항체의 동적 변화에 대한 1년 추적 연구Article Published on 2022-06-272022-09-12 Journal: International Journal of Medical Sciences [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] antibodies antibody cause CD4+ CD8+ change changed China circulating conducted discharge discharged Factor fluctuation Follow-up follow-up study gradually increased healthy hospital IgG and IgM IgG antibody IgM immune response inactivated leukocyte Leukocyte subsets Neutrophil-to-lymphocyte ratio NK cell observé participant Patient patients with COVID-19 protective antibodies recovered patient remained SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination subset Vaccine Virus-specific antibody. Virus-specific IgG [DOI] 10.7150/ijms.71286 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 RNA throughout wastewater treatment plants and a modeling approach to understand COVID-19 infection dynamics in Winnipeg, Canada폐수 처리장 전체에서 SARS-CoV-2 RNA 검출 및 캐나다 위니펙의 COVID-19 감염 역학을 이해하기 위한 모델링 접근 방식Article Published on 2022-06-152022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] applied approach Back-trajectory modeling Canada Concentration Consensus correlation correlations COVID-19 infection Data analysis detection discharge Final fluctuation fluctuations fraction indicated infected individual Infection initial plant plants positive control processing reached reduction RNA RNA concentrations sample collection SARS-CoV-2 SARS-CoV-2 RNA sensitivity Sludge suggested supernatant Surveillance Treatment virus virus concentration wastewater Wastewater solids wastewater surveillance water water cycle Winnipeg [DOI] 10.1016/j.scitotenv.2022.153906 PMC 바로가기 [Article Type] Article