Genetic Diversity, Antimicrobial Resistance Pattern, and Biofilm Formation in Klebsiella pneumoniae Isolated from Patients with Coronavirus Disease 2019 (COVID-19) and Ventilator-Associated PneumoniaResearch Article Published on 2021-12-242022-10-27 Journal: BioMed Research International [Category] COVID-19, 치료기술, [키워드] acute respiratory distress Analysis analyzed antimicrobial antimicrobial resistance antimicrobial susceptibility Belgium biofilm caused Cluster Clusters Consensus coronavirus disease COVID-19 COVID-19 pandemic cross-sectional diffusion method Diversity finding Formation Genetic genetic diversity Genotype hospital Hospitalized ICU Infection infections intensive care Iran isolate Isolated Klebsiella pneumoniae MDR multidrug resistant no significant difference Pathogens patients with COVID-19 pattern pneumoniae polymerase chain Prevalence resistance resistance to antibiotics risk significant difference significantly higher similarity syndrome VAP Ventilator-associated pneumonia was done was used [DOI] 10.1155/2021/2347872 PMC 바로가기 [Article Type] Research Article
Rapid determination of infectious SARS-CoV-2 in PCR-positive samples by SDS-PMA assisted RT-qPCRSDS-PMA 지원 RT-qPCR을 통한 PCR 양성 샘플의 감염성 SARS-CoV-2의 신속한 측정Article Published on 2021-11-252022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] assistance circumvent comparable conditions conjugate COVID-19 COVID-19 pandemic Ct value Culture Cutoff dead detect experiment facilitate Formation gold gold standard groups Health Health crisis heat heat-inactivated inactivated inactivation infectious particles less Live virus management MONITOR nucleic acid Patient PCR amplification PCR-positive Plaque assay PMA Prevent Rapid reduce released RT-qPCR SARS-CoV-2 SARS-CoV-2 nucleic acid SARS-CoV-2 transmission SARS-CoV-2 virion SDS storage Viral particles Viral RNA virion virions [DOI] 10.1016/j.scitotenv.2021.149085 PMC 바로가기 [Article Type] Article
The PERK/PKR-eIF2α Pathway Negatively Regulates Porcine Hemagglutinating Encephalomyelitis Virus Replication by Attenuating Global Protein Translation and Facilitating Stress Granule FormationCellular Response to Infection Published on 2021-10-132022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] activate activated activating Activation acute respiratory syndrome addition antiviral drugs antiviral role Betacoronavirus cause caused Cell Characteristics coronavirus Coronavirus replication coronavirus-infected cell coronavirus-infected cells Coronaviruses decrease disease Diseases double-stranded eIF2α eIF2α Encephalomyelitis Endoplasmic reticulum endoplasmic reticulum stress ER stress facilitate Facilitating Formation Granule high mortality rate Host Human in vitro in vivo infected cells Infection inhibited innate response Interaction interferon invading pathogen mechanism MERS-CoV Middle East modulate nerve cell neurotropic new treatment strategy Occurrence outcome pathogenic pathway Phosphorylation PKR porcine hemagglutinating encephalomyelitis virus promoted Protein protein translation regulate regulated Replication repressed respiratory syndrome coronavirus reveal SARS-CoV SARS-CoV-2 signaling pathway specific treatment stress granule suppressed target translation attenuation triggered turn unfolded protein response UPR viral proliferation viral replication virus [DOI] 10.1128/JVI.01695-21 PMC 바로가기 [Article Type] Cellular Response to Infection
Betacoronavirus Assembly: Clues and Perspectives for Elucidating SARS-CoV-2 Particle Formation and EgressMinireview Published on 2021-09-282022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Betacoronavirus caused characterized coronavirus coronavirus disease COVID-19 death described disease egress envelope protein Formation glycoprotein humans in viral involved knowledge membrane membrane curvature molecular mechanism New coronavirus nucleocapsid protein pandemic virus Particle Pneumonia produced Protein question raised Replication responsible SARS-CoV-2 spike glycoprotein structural protein structural proteins viral assembly viral entry viral particle Wuhan, China [DOI] 10.1128/mBio.02371-21 PMC 바로가기 [Article Type] Minireview
The Se–S Bond Formation in the Covalent Inhibition Mechanism of SARS-CoV-2 Main Protease by Ebselen-like Inhibitors: A Computational Study엡셀렌 유사 억제제에 의한 SARS-CoV-2 주요 프로테아제의 공유 결합 억제 메커니즘에서 Se-S 결합 형성: 전산 연구Article Published on 2021-09-102022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 치료제, [키워드] antiviral therapies apo form bond canonical catalytic dyad Combination complex covalent bond DFT Donor drug Ebselen Formation functional H-bond His41 hydrogen hydroxyl hydroxyl group inhibition inhibition mechanism knowledge less M pro mechanism member molecular dynamics Molecular dynamics simulation performed position potential energy potential energy surface protease Protease inhibitor SARS-CoV-2 SARS-CoV-2 main protease Se–S covalent bond selective Selenium sulfur theory [DOI] 10.3390/ijms22189792 PMC 바로가기 [Article Type] Article
D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Virus Titer via Enhanced Furin-Mediated Spike CleavageSARS-CoV-2 스파이크 단백질의 D614G 대체는 강화된 푸린 매개 스파이크 절단을 통해 융합체 형성 및 바이러스 역가를 증가시킵니다Research Article Published on 2021-07-272022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed Cell cleavage coronavirus D614G D614G substitution enhanced enhancement expressing S protein Formation furin furin cleavage site furin inhibitor increase isolates mechanism Mutation Plaque assay promote Protein rapid expansion respiratory S protein S proteins SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus significantly higher spike Substitution syncytium syncytium formation the S protein titer Transmissibility Treatment variant Viral viral isolate virus titer [DOI] 10.1128/mBio.00587-21 PMC 바로가기 [Article Type] Research Article
Virus-Negative Necrotizing Coronary Vasculitis with Aneurysm Formation in Human SARS-CoV-2 InfectionBrief Report Published on 2021-06-242022-10-30 Journal: Infectious Disease Reports [Category] COVID-19, [키워드] Anti-viral Arrhythmias business Coronary dose electrical Formation Human Immune-mediated IMPROVE Inflammation inflammatory disease Ireland Myocardial Myopericarditis necrotizing coronary vasculitis outcome polymerase chain Prednisone SARS-CoV-2 SARS-COV-2 infection subject suggested therapy tissue Vasculitis ventricular vessels virus [DOI] 10.3390/idr13030055 PMC 바로가기 [Article Type] Brief Report
Deletion of ER-retention motif on SARS-CoV-2 spike protein reduces cell hybrid during cell–cell fusionResearch Published on 2021-06-232022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] 293T A549 ACE2 administration Affect angiotensin-converting enzyme 2 assays binding Cell Cell fusion Cell hybrid cell line cell membrane co-culture Combination combinations COVID-19 Deletion downstream Ebola Effect event expressed expressing expressing S protein expression vectors Formation global pandemic hACE2-expressing cell HIV host cell host cell receptor human ACE2 human cell line implication in vitro assays infecting Interaction investigated mechanism motif mRNA mRNA vaccine mutated nuclear occur parameters Protein reduce reported Result S protein SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 spike protein SARS-CoV-2 vaccine Spike protein Structure supplementary material Syncytia syncytia formation the S protein the SARS-CoV-2 virus tissue tissue damage transduced Vaccine variant virus wild-type [DOI] 10.1186/s13578-021-00626-0 PMC 바로가기 [Article Type] Research
Two conserved oligomer interfaces of NSP7 and NSP8 underpin the dynamic assembly of SARS-CoV-2 RdRPNSP7 및 NSP8의 2개의 보존된 올리고머 인터페이스는 SARS-CoV-2 RdRP의 동적 조립을 뒷받침합니다.AcademicSubjects/SCI00010 Published on 2021-06-042022-09-10 Journal: Nucleic Acids Research [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] (RdRp Affect antiviral drug assays assembly biochemical complex complexes conserved coronavirus Critical crystal structure Formation Genome heterodimeric identify impairment implication Interaction interface mechanism Mutagenesis Mutation non-structural protein non-structural proteins Nsp12 Nsp7 NSP8 Protein provide RdRP Replication responsible reveal RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 genome selective solution stability the SARS-CoV-2 genome [DOI] 10.1093/nar/gkab370 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Molecular Simulation-Based Investigation of Highly Potent Natural Products to Abrogate Formation of the nsp10–nsp16 Complex of SARS-CoV-2SARS-CoV-2의 nsp10–nsp16 복합체 형성을 폐지하기 위한 매우 강력한 천연물에 대한 분자 시뮬레이션 기반 조사Article Published on 2021-04-142022-09-10 Journal: Biomolecules [Category] SARS, 치료기술, 치료제, [키워드] addition African antiviral drugs best binding affinity binding energy calculated complex Compound compounds conformational database demonstrated disrupt drug interaction Drug interactions feature Formation functional genkwanin inhibit innate immune system Interaction Interface residues investigation life cycle molecular molecular dynamic simulation molecular dynamics Molecular mechanics molecules mRNA natural natural product non-structural protein North nsp10 nsp10–nsp16 complex path potent product risk SARS-CoV-2 SARS-CoV-2 life cycle screened selected Side effects stability stable complex surface area Viral [DOI] 10.3390/biom11040573 PMC 바로가기 [Article Type] Article