Formation of a traditional Chinese medicine self-assembly nanostrategy and its application in cancer: a promising treatmentarticle Published on 2023-06-062024-09-05 Journal: Chinese Medicine [Category] update2024, [키워드] application Cancer Combined chemotherapy Formation Self-assembly nanostrategy Traditional Chinese medicine [DOI] 10.1186/s13020-023-00764-2 PMC 바로가기 [Article Type] article
The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia FormationArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome appear assays catalytic caused Cell cell-cell fusion cell-cell fusion assay cells cellular cellular component cellular membrane contribute coronavirus coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 pandemic dead defend Defense Efficiency ENhance entry of SARS-CoV-2 examined Formation genetic knockout global public health host cell membranes IFITM IFITMs in viral include Infection inhibiting inhibitory activity innate immune innate immune response Integral interact Interaction interfere intrinsic knockdown lentivirus maturation mechanism membrane membrane protein MHV mouse hepatitis virus nuclear overexpression pandemic Plaque assay precursor prelamin A Prevent protease Proteases PROTECT Protective protective role Protein proteolytic proteolytic activity reduce required restriction factor restriction factor. SARS-CoV-2 SARS-CoV-2 pseudovirus infection shown spike Therapeutic benefit transmembrane protein viral infection viral infections virus virus entry viruses wild-type ZMPSTE24 [DOI] 10.1128/mbio.02543-22 PMC 바로가기
Peculiarities of Humoral Immunity Formation in Medical Institution Employees Recovered from or Vaccinated against COVID-19 in Irkutsk이르쿠츠크에서 COVID-19에서 회복되거나 예방 접종을 받은 의료 기관 직원의 체액 면역 형성 특성Article Published on 2022-05-012022-09-12 Journal: Bulletin of experimental biology and medicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] antibody Asymptomatic case COVID-19 COVID-19 pandemic diagnosed with COVID-19 ELISA employee examined Formation humoral Humoral immunity institution Measures organized Patient performed population immunity recovered SARS-CoV-2 seropositive Seroprevalence specific antibodies the epidemic vaccinated against COVID-19 vaccination was measured [DOI] 10.1007/s10517-022-05492-5 PMC 바로가기 [Article Type] Article
Homologous and Heterologous Anti-COVID-19 Vaccination Does Not Induce New-Onset Formation of Autoantibodies Typically Accompanying Lupus Erythematodes, Rheumatoid Arthritis, Celiac Disease and Antiphospholipid SyndromeArticle Published on 2022-02-182022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Accompanying analyzed anti-SARS-CoV-2 antibody Antiphospholipid syndrome approved autoantibody Autoimmune diseases Autoimmunity booster vaccination caused CCP celiac disease collagenosis COVID-19 COVID-19 vaccination COVID-19 vaccine death effective Formation Germany IgA responses IgM immune response Immunity increases in Lupus mRNA vaccine Pandemics participant regimen reported respond Rheumatoid rheumatoid arthritis SARS-CoV-2 significantly subsequent sustained vaccination Vaccine vaccinee [DOI] 10.3390/vaccines10020333 PMC 바로가기 [Article Type] Article
Formation and Expansion of Memory B Cells against Coronavirus in Acutely Infected COVID-19 IndividualsArticle Published on 2022-01-292022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Activation analyzed antibodies antibody production Antibody Response avidity B cell B cells breadth circulating antibodies conserved coronavirus Coronaviruses COVID-19 cross-reactive Endemic expansion feature Formation generate IgG IgG antibody IgG response individual Infection investigated MBC memory memory B cell Mild naïve nucleocapsid plasmablasts Population Protein Proteins reactive reactivity Receptor binding domain Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein Severe infection subject the antibody response the N protein the S protein viral spike α-coronavirus β-coronavirus β-Coronaviruses [DOI] 10.3390/pathogens11020186 PMC 바로가기 [Article Type] Article
Acyl-Coenzyme A Synthetase Long-Chain Family Member 4 Is Involved in Viral Replication Organelle Formation and Facilitates Virus Replication via FerroptosisResearch Article Published on 2022-01-182022-10-29 Journal: mBio [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] ACSL4 coronavirus Coronaviruses death Encephalitis enterovirus family FDA-approved drugs Ferroptosis Formation genome-wide CRISPR screen genome-wide CRISPR screens Host in viral indicated induce Infection inhibitor inhibitors involved mechanism member Meningitis MOST myocarditis neurological organelle pathway poliomyelitis programmed cell death Pulmonary edema Replication severe complications Synthetase viral infection Viral load [DOI] 10.1128/mbio.02717-21 PMC 바로가기 [Article Type] Research Article
Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interactionSARS-COV-2 스파이크 수용체 결합 도메인의 돌연변이 조경 및 실리코 구조 모델에서 바이러스-호스트 상호 작용에 대한 주요 분자 결정 인자를 나타냅니다.Research Published on 2022-01-072022-09-10 Journal: BMC Molecular and Cell Biology [Category] 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 binding alteration Amino acid amino acid residues amino acid substitution Analysis analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 bat-CoV binding binding affinities binding affinity Binding interface causative agent changes in Clusters conserved Contact COVID-19 pandemic Deleterious mutations determinant enzyme focus Formation functional Future G496 G502 globe Host in silico in-silico independent infections Interaction interface mechanism molecular molecular rearrangement mutants mutate Mutation mutations N487 Non-synonymous mutation pandemic pangolin pangolin-CoV Phylogenetic analysis Protein Randomly RBD RBD mutation RBD mutations RBD residue RBD residues RBD-ACE2 RBDs Receptor binding domain reference strain remained residue Result RNA virus sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 RBD SARS-CoV-2 spike shown spike Spike protein stability suggested supplementary material sustained T500 the SARS-CoV-2 therapeutically target transmission rate variants of concern Viral viral entry virus virus infectivity Wuhan Y449 [DOI] 10.1186/s12860-021-00403-4 PMC 바로가기 [Article Type] Research
Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interactionResearch Published on 2022-01-072022-10-27 Journal: BMC Molecular and Cell Biology [Category] COVID-19, [키워드] ACE2 ACE2 binding alteration amino acid residues amino acid substitution Analysis analyzed bat-CoV binding binding affinity Binding interface changes in Clusters conserved Contact COVID-19 pandemic Deleterious mutations determinant Formation functional Future G496 G502 globe Host in silico in-silico independent infections Interaction mechanism molecular molecular rearrangement mutants mutate Mutation mutations N487 Non-synonymous mutation pandemic pangolin-CoV Phylogenetic analysis Protein Randomly RBD RBD mutation RBD residue RBD-ACE2 Receptor binding domain remained residue Result RNA virus sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RBD SARS-CoV-2 spike shown spike Spike protein stability suggested supplementary material sustained T500 the SARS-CoV-2 therapeutically target transmission rate variants of concern viral entry virus virus infectivity Wuhan Y449 [DOI] 10.1186/s12860-021-00403-4 PMC 바로가기 [Article Type] Research
Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interactionResearch Published on 2022-01-072022-10-27 Journal: BMC Molecular and Cell Biology [Category] Coronavirus, COVID-19, SARS, [키워드] ACE2 ACE2 binding alteration amino acid residues amino acid substitution Analysis analyzed bat-CoV binding binding affinity Binding interface changes in Clusters conserved Contact COVID-19 pandemic Deleterious mutations determinant Formation functional Future G496 G502 globe Host in silico in-silico independent infections Interaction mechanism molecular molecular rearrangement mutants mutate Mutation mutations N487 Non-synonymous mutation pandemic pangolin-CoV Phylogenetic analysis Protein Randomly RBD RBD mutation RBD residue RBD-ACE2 Receptor binding domain remained residue Result RNA virus sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RBD SARS-CoV-2 spike shown spike Spike protein stability suggested supplementary material sustained T500 the SARS-CoV-2 therapeutically target transmission rate variants of concern viral entry virus virus infectivity Wuhan Y449 [DOI] 10.1186/s12860-021-00403-4 PMC 바로가기 [Article Type] Research
A Brief Coaching Pilot Enhances Professional Identity Formation and Clinical Skills Acquisition During Emergency Medicine Clerkships Shortened by COVID-19Brief Educational Advances Published on 2022-01-012022-10-28 Journal: Western Journal of Emergency Medicine [Category] Coronavirus, SARS, [키워드] accelerate acquisition average clinical Coaching COVID-19 Emergency feasible Formation identity Intervention Medicine pandemic professional skill took place [DOI] 10.5811/westjem.2021.12.53917 PMC 바로가기 [Article Type] Brief Educational Advances