gene expression profile – Page 2 – Communicable Diseases Research

Extracellular vesicles in kidney disease

Reviews

Published on 2022-05-312022-10-05
Journal: Nature reviews. Nephrology
[Category] 바이오마커,

Identification of Diagnostic Gene Markers and Immune Infiltration in Systemic Lupus

전신성 루푸스에서 진단 유전자 마커 및 면역 침윤의 식별

Article

Published on 2022-05-102022-09-11
Journal: Computational and Mathematical Methods in Medicine
[Category] MERS, 바이오마커, 치료기술,

[키워드] Activation advancement Analysis analysis analyzed Atypical autoantibodies autoantibody Autoantigens Autoimmune disease B cells bioinformatics Biomarker Central nervous system characteristic clinical manifestation clinical manifestations Clinical practice coexpressed coexpression network complexes control group coronavirus coronavirus disease correlation COVID-19 current DEGs determine Diagnosis diagnostic differentially expressed gene Differentially expressed genes disease downloaded downregulated Endocrine endocrine system enrichment analysis etiology evaluate expression data Factors fraction functional gene expression profile Genes Genetic GEO database healthy control healthy controls help heterogeneous highest hub genes human body identification identify Immune cell immune cells Immune complexes immune function Infection Interaction joints KEGG kidney leukemia Lupus lupus erythematosus miRNA multiple organs Participation Pathogenesis pathway Pathways Patient patients performed Population Potential biomarker potential biomarkers PPI PPI network protein-protein interaction receiver operating characteristic recognize regulatory network Research resulting ribosome ROC ROC Curve RPL19 RPS17 RPS19 RPS7 selected skin SLE SLE patient SLE patients Symptom systemic systemic lupus erythematosus T cell T cells the disease the healthy transcription factor Treatment turquoise module upregulated variety virus was selected was used weighted gene coexpression network analysis WGCNA whole blood sample
[DOI] 10.1155/2022/3386999 PMC 바로가기 [Article Type] Article

Recognition of Immune Cell Markers of COVID-19 Severity with Machine Learning Methods

기계 학습 방법을 통한 COVID-19 심각도의 면역 세포 마커 인식

Article

Published on 2022-04-282022-09-11
Journal: BioMed Research International
[Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술,

[키워드] Algorithms analyzed B cell best Biomarker Biomarkers CD4 CD8 Cell cell type classifiers COVID-19 COVID-19 disease COVID-19 disease severity CX3CR1 Decision tree determine disease Disease progression disease severity feature filtered Gene expression analysis gene expression profile Host IL1B Immune cell immune cells immune response Immunological response immunological responses Inflammatory involved ITK KEGG pathway machine learning molecular mechanism molecular mechanisms monocyte Mortality NK cell Numerous PRDM1 random Random forest Recognition Regulation resulting SARS-COV-2 infection single-cell these cell These cells TLR2
[DOI] 10.1155/2022/6089242 PMC 바로가기 [Article Type] Article

Characterization of Altered Gene Expression and Histone Methylation in Peripheral Blood Mononuclear Cells Regulating Inflammation in COVID-19 Patients

COVID-19 환자의 염증을 조절하는 말초 혈액 단핵 세포에서 변경된 유전자 발현 및 히스톤 메틸화의 특성화

Article

Published on 2022-04-152022-09-11
Journal: Journal of immunology (Baltimore, Md. : 1950)
[Category] 유전자 메커니즘,

[키워드] alteration Altered Analysis approved arginase Bone marrow cause caused characterization chromosome correlated COVID-19 COVID-19 disease COVID-19 patients COVID-19 treatment Cytokines death Dexamethasone dysregulated Epigenetic expression expression pattern expression patterns expressions gene expression profile Gene expression profiles Genes healthy control healthy controls histone histone methylation hospitalized COVID-19 patient hospitalized COVID-19 patients IL-1 IL-17 IL-1B IL-6 indicated Inflammation information inhibitor investigated kinase kinases long noncoding RNA majority mechanisms member Methylation miRNA pandemic of COVID-19 pathway Pathway analysis Pathways PBMC PBMCs peripheral Potential biomarker potential biomarkers proinflammatory cytokines protein S provide receptor Regulating Regulation significantly target targets TEC TGF-β therapeutic target therapeutic targets treat Treatment upregulated variations von Willebrand factor was increased
[DOI] 10.4049/jimmunol.2101099 PMC 바로가기 [Article Type] Article

Tracing the SARS-CoV-2 infection on the ocular surface: Overview and preliminary corneoscleral transcriptome sequencing

안구 표면의 SARS-CoV-2 감염 추적: 개요 및 예비 각막 공막 전사체 시퀀싱

Article

Published on 2022-04-012022-09-11
Journal: Experimental eye research
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술,

[키워드] absence ADAMTS4 Analysis AQP5 associable caused Cluster Clusters component Cornea Corneal Corneoscleral ring COVID-19 CTRL Cytokines DEGs differentially expressed gene Differentially expressed genes Donor down-regulated gene down-regulated genes enrichment analysis Eye bank gene expression profile Gene ontology Genes genomic genomic RNA GO analysis GO term IL6 Illumina inactive indicated infected individual infected individuals Infection interferon interferon pathway ISG ISG15 ISGs Local Manifestations MMP1 modulation molecular mechanism molecular mechanisms ocular Ocular surface pathway PCA PCA analysis performed Perturbation positive Post-mortem principal Principal component principal component analysis proinflammatory cytokines Protective qRT-PCR RNA RNA-sequencing RSAD2 SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2. several gene several genes Support tears the interferon the SARS-CoV-2 tissue tracing transcriptional Transcriptome transcriptome analysis transcriptome sequencing virus was performed
[DOI] 10.1016/j.exer.2022.108975 PMC 바로가기 [Article Type] Article

Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations

노화된 전혈 전사체는 SARS-CoV-2 관련 혈관 및 면역 변화에 대한 후보 유전자를 나타냅니다

Article

Published on 2022-02-012022-09-11
Journal: Journal of Molecular Medicine (Berlin, Germany)
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adhesion affected age aging alteration anti-apoptotic BAG3 Blood Blood clots blood component blood components candidate candidate gene cascade cathepsin Cathepsins CCL4L2 CD14 CD4 CD8 Cell changes in clinical manifestation coronavirus COVID-19 CTSE CTSW database DEGs differentially expressed gene Differentially expressed genes DUSP4 expressed expression expression levels expression profile FASL FASLG female genders gene expression profile high viral load highest HLA-DRA Hyperinflammatory identify IFN IFN signaling immune immune response increase increase in increased expression individual Inflammation interact Interaction interferon investigated involved LAG3 Monocytes naïve T cells natural killer cell Natural killer cells Older older patient older patients overexpress overexpression PDCD1 Peripheral blood Platelet prediction Protein reveal RGS2 risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patient SARS-CoV-2-infected patients sequencing data severe acute respiratory syndrome Coronavirus severe COVID-19 Signaling Single-cell RNA-sequencing T cell T cell exhaustion T cells T lymphocytes target targets therapeutic TIGIT TOX Transcriptome translated type I interferon Vascular VCAM1 Viral load Viral protein Viral proteins Whole blood whole blood transcriptome whole blood.
[DOI] 10.1007/s00109-021-02161-4 PMC 바로가기 [Article Type] Article

Identification of potentially anti-COVID-19 active drugs using the connectivity MAP

연결 맵을 사용하여 잠재적으로 항 -CovID-19 활성 약물의 확인

Research Article

Published on 2022-01-272022-09-10
Journal: PLoS ONE
[Category] SARS, 신약개발, 유전자 메커니즘, 치료제,

[키워드] activating AMPK Analysis Anti-inflammatory applied Cancer cells catabolic Cell characterization Compound connectivity coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Cyclooxygenase database deleterious effect deleterious effects Dexamethasone drug Drug repurposing emergency response favor fluorometholone gene expression profile Gene expression profiles generate glucocorticoid Glucocorticoid receptor growth identification identify infected cells interfere involved lipid metabolism Map MDM2 metabolism modulate nitric oxide nitric oxide synthase organism Other other compounds Oxide p53 pandemic pathway proliferative reaction receptor resource respiratory Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Signaling tissue Transmission treat virus
[DOI] 10.1371/journal.pone.0262751 PMC 바로가기 [Article Type] Research Article

SC-MEB: spatial clustering with hidden Markov random field using empirical Bayes

SC-MEB: 경험적 Bayes를 사용한 숨겨진 Markov 랜덤 필드를 사용한 공간 클러스터링

Article

Published on 2022-01-172022-09-12
Journal: Briefings in Bioinformatics
[Category] 진단,

[키워드] Algorithm Analysis applied approach Cell cell cluster cell phenotype cell type Cluster Clustering Clustering analysis Clusters Colon Colorectal cancer complex COVID-19 dataset differential expression empirical Bayes expand expectation-maximization algorithm expression feasible fixed gene expression profile greater heatmap hidden hidden Markov random field identify immune iterative large sample Markov Markov random field microenvironment multicellular non-immune organization parameter Pathway analysis Patient performed provide question random Region regulated resolved Sample size Simulation study spatial information spatial transcriptomics. the mean tissue Transcriptome transcriptomic data transcriptomics
[DOI] 10.1093/bib/bbab466 PMC 바로가기 [Article Type] Article

Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets

흰 족제비에서 SARS-CoV-2 감염의 연령 의존적 병원성 특성

Article

Published on 2022-01-102022-09-12
Journal: Nature Communications
[Category] SARS, 진단, 치료기술,

[키워드] activated T cells age Characteristics clinical symptom Clinical symptoms Contact COVID-19 COVID-19 mortality COVID-19 patient COVID-19 patients COVID-19 severity direct contact ferret ferrets gene expression profile group groups healthy Human individuals infected with SARS-CoV-2 Infection inflammatory cell inflammatory cell infiltration interferon lung Macrophage macrophage responses manifestation mimicking nasal not differ Older Pathogenesis pathogenesis of SARS-CoV-2 pathogenic Patient reveal SARS-CoV-2 SARS-COV-2 infection Seroprevalence severe COVID-19 patients severe symptom severe symptoms severely infected patients significantly T cells Transcriptome transcriptome analysis transcriptomic profile Transmission type I interferon Viral host response viral loads Viral transmission virus while
[DOI] 10.1038/s41467-021-27717-3 PMC 바로가기 [Article Type] Article

The reactome pathway knowledgebase 2022

AcademicSubjects/SCI00010

Published on 2022-01-072022-10-31
Journal: Nucleic Acids Research
[Category] COVID-19,

[키워드] acquired disease Analysis analyzed annotation biological processe caused coronavirus curated dataset disease-associated drug ELIXIR function functional gene expression profile host response humans Infection molecular Mutation New pathway Pathways physiological Protein provide recent resource SARS-CoV-1 SARS-CoV-2 Signaling Support tumor cells
[DOI] 10.1093/nar/gkab1028 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010