genetic study – Page 2 – Communicable Diseases Research

SARS-CoV-2 infection susceptibility influenced by ACE2 genetic polymorphisms: insights from Tehran Cardio-Metabolic Genetic Study

ACE2 유전적 다형성의 영향을 받는 SARS-CoV-2 감염 감수성: 테헤란 심장 대사 유전 연구의 통찰력

Article

Published on 2021-01-152022-09-01
Journal: Scientific Reports [Category] 변종, 유전자 메커니즘, 진단, 치료기술,

The RNA Architecture of the SARS-CoV-2 3′-Untranslated Region

SARS-CoV-2 3'-미번역 영역의 RNA 아키텍처

Article

Published on 2020-12-212022-09-10
Journal: Viruses [Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] 3′ UTR 3′ untranslated region 3′ UTR absence acute respiratory syndrome acute respiratory syndrome coronavirus Analysis architecture binding BSL can not Cell coronavirus covariation COVID-19 COVID-19 pandemic dimethyl sulfate DMS DMS-MaPseq DREEM element equilibrium functional genetic study include minigene molecular Nsps Phylogenetic Plasmid polymerase pseudoknot Region Replication respiratory responsible RNA SARS-CoV-2 Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 ShapeKnots Structure sulfate supported the SARS-CoV-2 three-helix junction Transcription transfected cells untranslated region UTR Viral viral genome viral nonstructural protein viral nonstructural proteins Viral RNA virion β-CoV
[DOI] 10.3390/v12121473 PMC 바로가기 [Article Type] Article

Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility

Article

Published on 2020-11-102022-10-04
Journal: Cell Discovery [Category] 변종, 유전자 메커니즘, 임상, 치료기술,

[키워드] accounted Affect allele allele frequency Analysis association Asymptomatic Asymptomatic disease bioinformatics Chinese Chinese patient complex diseases conducted confounding factors COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 severity Critical Critically ill death disease severity DPP7 effort FIVE General population Genetic genetic architecture genetic study genetic variants Genome-wide association studies genomic GOLGA3 group help Host IL-1 ill patient Infection initial Interaction International involved Laboratory limitation locus loss of function manifestation Mechanisms of disease Mild missense variant moderate outbreak outcome Patient patients phenotypic provide Sequencing Severe patient severity Shenzhen signaling pathway significantly stability suggested susceptibility TMPRSS2 protein Variability variant whole-genome sequencing
[DOI] 10.1038/s41421-020-00231-4 PMC 바로가기 [Article Type] Article

The role of host genetics in susceptibility to severe viral infections in humans and insights into host genetics of severe COVID-19: A systematic review

Review

Published on 2020-09-092022-10-04
Journal: Virus research [Category] SARS, 유전자 메커니즘,

[키워드] accompanied addition C-lectin pathways candidate gene Case report caused CCR1 CCR9 coronavirus coronavirus endoribonuclease COVID-19 COVID-19 case COVID-19 GWAS COVID-19 pathogenesis Cytokine storm DC-SIGN DC-SIGN, Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin DC-SIGNDendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin deficiency Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin disease double-strand RNA dsRNA, double-strand RNA dsRNAdouble-strand RNA dysregulated endoU, coronavirus endoribonuclease endoUcoronavirus endoribonuclease Evidence explain expression genetic study Genetic variant genome wide association studies GWAS GWAS, genome wide association studies GWASgenome wide association studies Herpes Simplex Virus 1 herpses simplex encephalitis Host host genetics Host immune defenses HSE, herpses simplex encephalitis HSEherpses simplex encephalitis HSV-1, Herpes Simplex Virus 1 HSV-1Herpes Simplex Virus 1 Human hypothese IL-18 IL-18 binding protein IL-18BP, IL-18 binding protein IL-18BPIL-18 binding protein immune immune response gene immune system implicated inborn errors of immunity Inclusion Inflammasome inflammasome activation Interaction interferon Interleukins International Union of Immunological Societies IUIS, International Union of Immunological Societies IUISInternational Union of Immunological Societies lactate dehydrogenase latency LDH, lactate dehydrogenase LDHlactate dehydrogenase lectin manifestation medical subject heading MeSH, medical subject heading MeSHmedical subject heading Meta-analysis minor allele frequency NLRP1 objective OMIM, Online Mendelian Inheritance in Man (OMIM) OMIMOnline Mendelian Inheritance in Man (OMIM) Online Mendelian Inheritance in Man (OMIM) Pathogenesis pathway Pathways PBMCs, peripheral blood mononuclear cells PBMCsperipheral blood mononuclear cells Peripheral blood mononuclear cells Protein reported Result SARS Coronavirus SARS coronavirus 2 SARS-coronavirus 2 SARS-CoV SARS-CoV-2 SARS-CoV-2, SARS Coronavirus 2 SARS-CoV-2SARS Coronavirus 2 SARS-CoV, SARS Coronavirus SARS-CoVSARS Coronavirus severe COVID-19 Study design susceptibility systematic review therapeutic targets TLR pathway TLR pathways treatment for COVID-19 variant viral disease viral infection Viral susceptibility
[DOI] 10.1016/j.virusres.2020.198163 PMC 바로가기 [Article Type] Review

Low level of genetic diversity and high occurrence of vector-borne protozoa in water buffaloes in Thailand based on 18S ribosomal RNA and mitochondrial cytochrome b genes

article

Published on 2020-08-312024-09-01
Journal: Infection, Genetics and Evolution [Category] 말라리아,

[키워드] genetic study Plasmodium bubalis Prevalence Theileria orientalis water buffalo
[Article Type] article

Coronavirus disease (COVID-19): a scoping review

Review

Published on 2020-04-162022-10-31
Journal: Eurosurveillance [Category] COVID-19,

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

정밀 의학(TOPMed)을 위한 100,000개 이상의 NHLBI Trans-Omics 컨소시엄 전체 게놈 서열의 사용은 아프리카 및 히스패닉/라틴계 혼합 인구 집단에서 전가 품질 및 희귀 변이 연관성 검출 개선

Research Article

Published on 2019-12-232022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 1000 Genomes Project addition African allele Analysis Anemia approach association average blood cell complex complex diseases conducted demonstrated European Frequency genetic architecture Genetic studies genetic study genome coverage genome-wide association genome-wide genotyping genome-wide significant Genotype genotype data genotype imputation genotypes Haplotype Reference Consortium HBB HBB gene HCT hematocrit hematological hemoglobin highlight homozygous impair IMPROVE imputation increase in independent individual information Linkage disequilibrium low frequency MAF mapping Medicine minor allele frequency MOST NHLBI phase Population populations power Quantitative rare variant Rare variants reference panel replicated rescued sequence Sequencing sequencing data subsequent traits utility variant variants WBC White blood cell white blood cell count whole genome whole genome sequence Whole genome sequencing
[DOI] 10.1371/journal.pgen.1008500 PMC 바로가기 [Article Type] Research Article

Identity-by-descent analyses for measuring population dynamics and selection in recombining pathogens

재결합 병원체에서 개체군 역학 및 선택을 측정하기 위한 혈통별 식별 분석

Research Article

Published on 2018-05-232022-09-06
Journal: PLoS Genetics [Category] Communicable Disease, 말라리아,

[키워드] added addition Analysis antimalarial antimalarial drug Artemisinin Asia can be used clonal expansion comparison Comparisons country Critical critical regions dataset descent determine disease disease control disease transmission Diseases distributions drug resistance Efficacy effort evaluate events Exploratory analysis gene flow genetic diversity genetic study Genome genomes genomic genomic data genomic region Haplotype IBD identification identify independent infections Infectious disease Infectious diseases isolate isolates lack loci malaria methodology microorganism microorganisms multiple infections natural selection Organisms overlap pathogen Pathogens Plasmodium Plasmodium falciparum population bottleneck population bottlenecks populations Positive selection reduced regions selected selection pressure sequencing data Spread statistical methodologies statistical methodology statistical model Transmission Treatment whole genome Whole genome sequencing
[DOI] 10.1371/journal.pgen.1007279 PMC 바로가기 [Article Type] Research Article

Pheromone independent unisexual development in Cryptococcus neoformans

Cryptococcus neoformans의 페로몬 독립 성 발달

Research Article

Published on 2017-05-032022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activator allele Analysis Bifurcation bisexual reproduction calcineurin cellular cellular differentiation Complete completion component condition conditions contributed Cryptococcus Cryptococcus neoforman Cryptococcus neoformans differentiation processe distribution dominant door ENhance eukaryotic expression favor fungus generate genetic control genetic study higher eukaryotes hyphal inactivation independent independent of inefficient inhibitory insertional mutagenesis isolate Laboratory Like mating type mating types meiosis microbe mode opens pathway pheromone Population predicted Prevalence progeny promote Protein repressor required robust sexual development sexual reproduction skewed skewed distribution specific proteins suppresse tested transcription factor Transcriptome undergo Znf2
[DOI] 10.1371/journal.pgen.1006772 PMC 바로가기 [Article Type] Research Article

Beyond the MHC: A canine model of dermatomyositis shows a complex pattern of genetic risk involving novel loci

MHC 너머: 피부근염의 송곳니 모델은 새로운 유전자좌와 관련된 유전적 위험의 복잡한 패턴을 보여줍니다

Research Article

Published on 2017-02-032022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] affected age of onset alleles allelic combination animal model artificial selection association Autoimmune disease biological samples canine chromosome chromosomes Combination complex complex disease complex diseases components conducted conserved conserved regions contribute correlated dermatomyositis disease disease pathogenesis Disease progression disease risk driven by dysfunction encoding Evidence explain exploration Frequency gene-gene interaction Genetic genetic interactions genetic risk genetic risk factor genetic study Genome Genome-wide association studies Genome-wide association study Genotype genotype-phenotype correlation genotypic genotyping Haplotype haplotypes healthy heterogeneity high risk highlight homozygosity human populations identify immunological impacted incidence independent independent of indicated Inflammatory inflammatory disease influences Interaction inverse correlation investigated involved Isolation juvenile dermatomyositis loci major histocompatibility complex MAP3K7CL mapping MHC moderate muscle Myopathy nine PAN2 pattern Phenotypes polymorphism Probability provided Region risk risk allele skin subjects susceptibility susceptibility loci target targets the major histocompatibility thought unique utility Vasculopathy whole genome
[DOI] 10.1371/journal.pgen.1006604 PMC 바로가기 [Article Type] Research Article