Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: A systematic review and meta-analysisCOVID-19 질병 및 중증도에 대한 감수성과 관련된 유전적 다형성: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-07-062022-09-11 Journal: PLoS ONE [Category] 변종, [키워드] 95% CI ACE1 advanced age allele alleles analyzed ApoE article association C allele calculated candidate gene CCR5 clinical symptom Clinical symptoms Comorbidities contribute COVID-19 COVID-19 disease COVID-19 infection COVID-19 pathogenesis COVID-19 severity disease eligible fixed form forms Genetic polymorphism genetic polymorphisms Genetic variant genetic variants GWAS HLA HLA-A HLA-B HLA-C identify investigated involved loci Meta-analysis polymorphism Polymorphisms presence of comorbidity random Repository risk searched severe forms of COVID-19 severity of COVID-19 significantly Stata software suggested susceptibility systematic review the disease TMPRSS2 Variation [DOI] 10.1371/journal.pone.0270627 PMC 바로가기 [Article Type] Meta-Analysis
Mendelian randomization study on the causal effects of COVID-19 on childhood intelligenceCOVID-19가 아동기 지능에 미치는 인과적 영향에 대한 멘델식 무작위 배정 연구Article Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] Fulltext, MERS, 변종, [키워드] 95% confidence interval Affect analyses Analysis anaplastic causal link change childhood childhood intelligence condition Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Decline declines demonstrated Effect European evaluate the effect Genetic genetic susceptibility genetic variants Genome-wide association study genome-wide association study. GWAS Hospitalized identify increased risk individual lung Lungs mendelian randomization metaplastic Odds ratio organ systems other organ other organs pathogenic resulting risk factor simple mode variant was used weighted median weighted mode [DOI] 10.1002/jmv.27736 PMC 바로가기 [Article Type] Article
Receptor binding domain of SARS-CoV-2 from Wuhan strain to Omicron B.1.1.529 attributes increased affinity to variable structures of human ACE2우한 균주에서 Omicron B.1.1.529까지의 SARS-CoV-2 수용체 결합 도메인은 인간 ACE2의 가변 구조에 대한 증가된 친화성을 특성으로 합니다.Article Published on 2022-07-012022-09-11 Journal: Journal of infection and public health [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] ACE2 ACE2 receptor ACE2 receptors ACE2 variant ACE2 variants ACE2-RBD affinity analysed analysis angiotensin Angiotensin-converting enzyme attribute B.1.1.529 binding binding domain binding efficiency binding energy Care caused changes in coding region Complexes complexes contributing to COVID-19 detect determine docking dynamic Dynamic simulation enzyme Genetic variant genetic variants global pandemic help highlight homology model Homology models Human human ACE2 human host Infectious disease Interaction isolates lead management molecular molecular dynamics nucleotide omicron pathogenic polymorphism Protein docking RBD RBD complex RBDs receptor Receptor binding domain Repository retrieved risk RMSD RMSF Safe SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 virus SARS‐CoV‐2 SARS‐CoV‐2. selected severity single nucleotide stability Structural variant structural variants Structure the RBD Total variant Variation was performed wildtype Wuhan Wuhan strain [DOI] 10.1016/j.jiph.2022.06.004 PMC 바로가기 [Article Type] Article
High-affinity FcγRIIIa genetic variants and potent NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) responses contributing to severe COVID-19고친화성 FcγRIIIa 유전적 변이체와 강력한 NK 세포 매개 항체 의존성 세포독성(ADCC) 반응이 심각한 COVID-19에 기여Article Published on 2022-07-012022-09-11 Journal: Genetics in medicine : official journal of the Ame [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] activating Activation ADCC ADCC assay antibody antibody-dependent cellular cytotoxicity approach association cell receptor cell receptors cellular cytotoxicity contribute contributing to COVID-19 COVID-19 severity Deceased disease severity Evidence experiments expressing expression FCGR3A FcγRIIIa functional Genetic genetic association Genetic variant genetic variants hallmark Hospitalized hospitalized patient hospitalized patients Immunopathogenesis in vitro investigated limit Mild natural killer NK cell NK cells occur Patient patients with COVID-19 proinflammatory provide receptor response resulting SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 infections Sequence variant. severe COVID-19 severity of COVID-19 significantly significantly higher subsequent variant with COVID-19 [DOI] 10.1016/j.gim.2022.04.005 PMC 바로가기 [Article Type] Article
Presence of rare potential pathogenic variants in subjects under 65 years old with very severe or fatal COVID-19매우 심각하거나 치명적인 COVID-19가 있는 65세 미만의 피험자에서 드문 잠재적 병원성 변이의 존재Article Published on 2022-06-202022-09-11 Journal: Scientific Reports [Category] 바이오마커, 변종, 유전자 메커니즘, [키워드] affecting Analysis Blood coagulation carbohydrate cohort of patients components composed COVID-19 COVID-19 patient COVID-19 severity death Defense described DNA Exome explain fatal COVID-19 Genes Genetic variant genetic variants help Host host defense immune response immunodeficiency interconnected gene intubation involved mechanism metabolism network analysis outcome pathogen pathogenic pathogenic variant Pathogens Patient patients Presence Rare variants required resulting selected Sequencing subject variant variants variants of interest [DOI] 10.1038/s41598-022-14035-x PMC 바로가기 [Article Type] Article
Beyond GWAS-Could Genetic Differentiation within the Allograft Rejection Pathway Shape Natural Immunity to COVID-19?GWAS를 넘어 동종이식 거부 경로 내 유전적 분화가 COVID-19에 대한 자연 면역을 형성할 수 있습니까?Article Published on 2022-06-032022-09-11 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Allograft allograft rejection Analysis annotation antiviral immunity applied Biomarker Biomarkers chromosome chromosome 6 chromosomes clinical presentation component components COVID-19 COVID-19 infection COVID-19 infections cumulative demonstrated differentiation disease Factor Genetic genetic variants genetics Genome-wide association study genomic GWAS Health help hospitalisation Host identify immune response immune responses immune system immunisation Infection investigated KEGG KEGG pathways Linear model majority mapped metabolic pathway metabolic pathways natural nucleotide outcome pathway Pathways Patient rejection resistance risk Risk assessment self Sequencing severe COVID-19 Severe COVID-19 Infection shape single nucleotide Single nucleotide polymorphism single variant SNP SNPs susceptibility Treatment variant whole genome Whole genome sequencing whole genome sequencing. [DOI] 10.3390/ijms23116272 PMC 바로가기 [Article Type] Article
Enabling Artificial Intelligence for Genome Sequence Analysis of COVID-19 and Alike VirusesCOVID-19 및 유사 바이러스의 게놈 서열 분석을 위한 인공 지능 지원Article Published on 2022-06-012022-09-11 Journal: Interdisciplinary sciences, computational life sci [Category] COVID19(2023년), SARS, 변종, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alignment amino acids Analysis antiviral drugs artificial artificial intelligence Behavior caused Classifier coronavirus 2 count COVID-19 Data analysis Data center data set DNA Ebola Enabling Frequency Genetic variant genetic variants genome sequence Genome sequence analysis Genome sequences Health help information intelligence machine machine learning MERS Middle East respiratory syndrome nucleotide nucleotides pandemic of COVID-19 recent Repository researcher SARS-CoV-2 sequence Sequence analysis Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus similarity Support SVM SVM. syndrome Vaccines virus virus virus genome viruses [DOI] 10.1007/s12539-021-00465-0 PMC 바로가기 [Article Type] Article
Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infectionSARS-CoV-2 감염과 관련된 유전자의 유전적 변이 및 임상 표현형과의 연관성에 대한 자연 선택의 영향Article Published on 2022-05-242022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, [키워드] 1000 Genomes Project ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive African African diversity Amino acid amino acid change analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Antigen association caused clinical phenotype clinical phenotypes complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dipeptidyl peptidase Dipeptidyl peptidase 4 DPP4 Electronic health record Electronic health records enzyme European Genetic genetic diversity genetic variants Genetic variation Genome genomic Haplotype haplotypes Health host gene host genes Human identify Impact in some individual investigated involved Lineage locus LY6E lymphocyte minor allele frequency natural selection nonsynonymous variant pandemic patients with COVID-19 phenotype phenotype association. populations Positive selection protease Protein provide regulatory region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2/COVID-19 Serine serine 2 severe acute respiratory syndrome Coronavirus target targets TMPRSS2 transmembrane transmembrane protease serine 2 variant Variation viral infections viruses [DOI] 10.1073/pnas.2123000119 PMC 바로가기 [Article Type] Article
Genetic and Clinical Characteristics of Patients in the Middle East With Multisystem Inflammatory Syndrome in Children중동의 소아 다기관 염증 증후군 환자의 유전적 및 임상적 특성Multicenter Study Published on 2022-05-022022-09-11 Journal: JAMA Network Open [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI age Asian association attributes children clinical Clinical characteristics Clinical course Clinical outcome clinical outcomes cohort study complications conducted contribute Control control group controls Deleterious disease disease entity disease onset dose dysregulated Exome Fisher exact test Genetic genetic finding genetic findings Genetic variant genetic variants healthy children heterozygous variant identify IFNA6 IFNB1 IL22RA2 immune-related genes Immunoglobulin Inflammatory Inflammatory marker inflammatory markers Intravenous immunoglobulin Jordan laboratory biomarkers laboratory characteristics male manifestation Mann-Whitney U test matched control middle Middle East MIS-C multicenter cohort study neurologic organ organ system outcome participant participated Patient Population recruited reported SARS-CoV-2 SARS-COV-2 infection Sequencing significantly syndrome TLR3 TLR6 Treatment United Arab Emirate United Arab Emirates variant variants was performed was used were measured [DOI] 10.1001/jamanetworkopen.2022.14985 PMC 바로가기 [Article Type] Multicenter Study
Epidemiological Features of COVID-19 in Northwest Russia in 20212021년 러시아 북서부 COVID-19의 역학적 특징Article Published on 2022-04-292022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] age Alpha Analysis assessment AT.1 variant base Beta carried changes in characteristic characterized China circulating Coronavirus infection COVID-19 COVID-19 incidence COVID-19 pandemic decrease Delta delta variant epidemiological epidemiological situation epidemiological surveillance Europe feature Federal District fluctuation fluctuations Genetic Genetic variant genetic variants global health globe Health highlight increase International Lineage lineages megacity morbidity mortality rate mortality rates Northwest Russia Novel coronavirus Novel coronavirus infection occurred omicron pandemic Pasteur Institute Phylogenetic Phylogenetic tree population density progression provided reached replaced Russia Saint Petersburg SARS-CoV-2 SARS-CoV-2 strains severe COVID-19 severity shown Spread strain Surveillance Transport vaccination variant variants variants of concern variants of concern. VoC Wuhan [DOI] 10.3390/v14050931 PMC 바로가기 [Article Type] Article