GIANA allows computationally-efficient TCR clustering and multi-disease repertoire classification by isometric transformationArticle Published on 2021-08-042022-10-04 Journal: Nature Communications [Category] MERS, SARS, 바이오마커, [키워드] Accuracy Adaptive immunity Antigen Autoimmune disease Autoimmune diseases Cancer Cluster Clustering Cohort dataset diagnostic Genome informatics grouping immune immunological inefficient isometric transformation Non-invasive Patient platform provide receptors sequence sequence similarity similarity specificity T-cell receptor TCR TCR sequences TCRs therapeutic targets [DOI] 10.1038/s41467-021-25006-7 PMC 바로가기 [Article Type] Article
Deep learning identifies antigenic determinants of severe SARS-CoV-2 infection within T-cell repertoiresArticle Published on 2021-07-122022-10-04 Journal: Scientific Reports [Category] SARS, 진단, [키워드] Analysis antigenic asymptomatic infection Biomarkers characterized Classifier Clinical course Clinical outcome clinical presentation Cohort Computational biology and bioinformatics Computational models Critical care database deep deep learning determinant Diseases epitope Evidence Factor Genome informatics identify ImmuneCODE immunology individual Infection machine learning management Medical research Patient physician predict responses SARS-CoV-2 epitope SARS-COV-2 infection Sequencing Severe infection severe SARS-CoV-2 severity Support T-cell T-cell receptor T-cell Response Variation [DOI] 10.1038/s41598-021-93608-8 PMC 바로가기 [Article Type] Article
SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions브라질의 SARS-COV-2 돌연변이 : 유전체학에서 추정 임상 조건까지Article Published on 2021-06-072022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료제, [키워드] Analysis Brazil clinical condition COVID-19 outbreak Drug discovery evaluate Genes Genetic association study Genome Genome informatics genomes genomic host cells Interaction involved life cycle mutate Mutation ORF3a ORF6 prevalent Protein protein structures Region SARS-CoV-2 SARS-CoV-2 mutation selective spreads Stage Structural analysis structures Transmissibility Vaccine development Viral viral life cycle [DOI] 10.1038/s41598-021-91585-6 PMC 바로가기 [Article Type] Article
Coagulation factors and the incidence of COVID-19 severity: Mendelian randomization analyses and supporting evidenceLetter Published on 2021-06-072022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 유전자 메커니즘, [키워드] coagulation factor Evidence Genetics research Genome informatics incidence of COVID-19 Mendelian randomization analysis Predictive markers [DOI] 10.1038/s41392-021-00640-1 PMC 바로가기 [Article Type] Letter
A global resource for genomic predictions of antimicrobial resistance and surveillance of Salmonella Typhi at pathogenwatch항생제 내성의 유전체 예측 및 병원체 감시를 위한 글로벌 자원, 살모넬라 장티푸스(Pathogenwatch)Article Published on 2021-05-172024-07-29 Journal: Nature Communications [Category] 살모넬라증, [키워드] Computational platforms and environments Epidemiology Genome informatics Policy and public health in microbiology [DOI] 10.1038/s41467-021-23091-2 PMC 바로가기 [Article Type] Article
Analysis of SARS-CoV-2 mutations in the United States suggests presence of four substrains and novel variants미국에서 SARS-CoV-2 돌연변이를 분석한 결과 4개의 하위 균주와 새로운 변이가 있음을 시사합니다.Article Published on 2021-02-152022-09-10 Journal: Communications Biology [Category] MERS, 변종, 치료법, [키워드] Analysis Cluster Complete comprehensive analysis female Gender Genome informatics group groups immune system male Mutation mutations ORF8 Patient SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 genomes SARS-CoV-2 infections SARS-CoV-2 mutation sequence sequenced single mutations Spike protein the spike protein the United State The United States United States variant Viral viral control viral infection [DOI] 10.1038/s42003-021-01754-6 PMC 바로가기 [Article Type] Article
Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19세로 전사체 분석은 COVID-19에서 회복하는 동안 강력한 T 세포 면역을 보여줍니다Article Published on 2020-12-242022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Analysis AP-1 Clinical features Clinical stages convalescence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 creation differentially expressed differentiation disease downregulated driven by event Genome informatics Humoral immunity immune protection immune regulation immune response immune responses Immunity indicated Infectious diseases long non-coding RNA longitudinal Messenger RNA messenger RNAs microRNA MicroRNAs miRNAs mononuclear cell mRNAs occurred Patient PBMC performed Peripheral blood regulatory network rehabilitation respiratory RNA sequencing robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus signaling pathway significantly T cell T-cell activation Transcriptome Treatment type I interferon type I interferon response understanding [DOI] 10.1038/s41392-020-00457-4 PMC 바로가기 [Article Type] Article
Stepwise evolution of Salmonella Typhimurium ST313 causing bloodstream infection in Africa아프리카에서 혈류 감염을 일으키는 살모넬라 타이피무리움 ST313의 단계적 진화Article Published on 2020-12-212024-08-19 Journal: Nature Microbiology [Category] 살모넬라증, [키워드] Computational biology and bioinformatics Genome informatics molecular evolution phylogenetics Phylogeny [DOI] 10.1038/s41564-020-00836-1 PMC 바로가기 [Article Type] Article
No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2SARS-CoV-2의 재발성 돌연변이로 인한 전염성 증가에 대한 증거 없음Article Published on 2020-11-252022-09-10 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, [키워드] adaptation allele animal reservoir association caused circulation clade coronavirus coronavirus SARS-CoV-2 COVID-19 curated dataset descendant descendants develop Evidence Genome informatics homoplasies homoplasy human host Human immune system human population humans identify Lineage Mutation mutations natural selection Neutral patients worldwide Phylogenetic phylogenetics recurrent mutation RNA SARS-CoV-2 SARS-CoV-2 genome significantly significantly more Transmissibility Viral Viral genetics Viral transmission [DOI] 10.1038/s41467-020-19818-2 PMC 바로가기 [Article Type] Article
The global population of SARS-CoV-2 is composed of six major subtypesArticle Published on 2020-10-262022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] accumulate amino acid replacement approach candidate vaccine characterized Clustering compose composed Computational biology and bioinformatics confounding effect COVID-19 drugs early stage Effectiveness Evolution Genes Genetic Genetic variation Genome informatics Genotype Implications Mutation nucleocapsid ORF8 pandemic phenotypic polymorphism Polymorphisms Population Population genetics populations Protein provide Randomly reduce responsible robust SARS-CoV-2 sequence subtype Subtypes the SARS-CoV-2 the Spike Trial virus World Health Organization [DOI] 10.1038/s41598-020-74050-8 PMC 바로가기 [Article Type] Article