Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure Research Published on 2020-10-052022-10-05 Journal: Nature Genetics [Category] 변종, [키워드] accumulate Analysis Cancer Chromatin structure dataset distribution domains Factor generate Genome genome organization human cancers inactive Mutation mutational processe mutational processes Replication somatic mutation Therapeutic strategies understanding Variation whole-genome [DOI] 10.1038/s41588-020-0708-0 [Article Type] Research
Understanding genomic diversity, pan-genome, and evolution of SARS-CoV-2Bioinformatics Published on 2020-07-172022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] Analysis analyzed ancestor bat bioinformatics contributed coronavirus CoV COVID-19 Diagnosis disease Epidemiology Evolution Evolution of SARS-CoV-2 Genome genome organization genomic Genomics genus Betacoronavirus help homology hosts indicate Infection isolate isolates majority medium mutational hotspot mutations novel virus pandemic pangolin pathogenicity Phylogeny predicted Probability respiratory SARS SARS-CoV SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains sequenced the SARS-CoV-2 genome Treatment understanding unique viral disease Wuhan, China [DOI] 10.7717/peerj.9576 PMC 바로가기 [Article Type] Bioinformatics
Comparative genomics of whole-cell pertussis vaccine strains from India인도에서의 전체 세포 백일해 백신 균주의 비교 유전체학Research Article Published on 2020-05-072024-07-28 Journal: BMC Genomics [Category] 백일해, [키워드] antigenic variation Bordetella pertussis genome organization resurgence Vaccine-mediated selection virulence genes Whooping cough [DOI] 10.1186/s12864-020-6724-8 PMC 바로가기 [Article Type] Research Article
Long transposon-rich centromeres in an oomycete reveal divergence of centromere features in Stramenopila-Alveolata-Rhizaria lineages난균류의 긴 트랜스포존이 풍부한 중심체는 Stramenopila-Alveolata-Rhizaria 계통에서 중심체 기능의 발산을 나타냅니다.Research Article Published on 2020-03-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Aneuploidy assembly binding Cell cell division centromere ChIP-seq chromatin chromatin immunoprecipitation chromosomal chromosomal region chromosome segregation Cluster CoLT criterion diatoms Divergence DNA sequence DNA sequences element eukaryotes Evolution facilitated feature focus followed by Frequency functional fungal Genome genome assembly genome organization genomes help heterochromatin identification identify knowledge lack life life stage Lineage Long microorganism microorganisms Modification MOST nuclear organism Plasmodium Plasmodium falciparum platform provide reference strain Region regions reveal SAR Sequencing subset transcribed transposon turn [DOI] 10.1371/journal.pgen.1008646 PMC 바로가기 [Article Type] Research Article
Insights into the Recent 2019 Novel Coronavirus (SARS-CoV-2) in Light of Past Human Coronavirus OutbreaksReview Published on 2020-03-042022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] 2019-nCoV addition China contagious coronavirus CoV COVID-19 CoVs death develop Evolution Fatality rate genome organization human coronavirus human CoV insight LIGHT MERS MERS-CoV Middle East novel number of infected outbreak Outbreaks public health recent reported respiratory Respiratory illness RNA virus SARS SARS-CoV SARS-CoV-2 severe viral pneumonia target cells treatment strategy virus Wuhan, China [DOI] 10.3390/pathogens9030186 PMC 바로가기 [Article Type] Review
Comparative 3D genome organization in apicomplexan parasitesArticle Published on 2019-02-192024-08-28 Journal: Microbial Cell Factories [Category] 말라리아, [키워드] epigenomics genome organization Hi-C malaria virulence
Detection and full genome characterization of two beta CoV viruses related to Middle East respiratory syndrome from bats in ItalyResearch Published on 2017-12-192022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] aa deletion absence Analysis bat bats binding affinity cause cell lines China clade coronavirus CoV detection domain full genome sequencing Genome genome organization Host Human human DPP4 humans infect Ion Isolation Italian Italy macromolecular MERS MERS-CoV MERS-like Beta-CoV viruses Middle East Multiple PDB performed Phylogenetic Phylogenetic and molecular analyses Phylogenetic tree Pipistrellus platform pool positive predicted Protein RBD RBDs receptor Receptor binding domain recorded reported respiratory syndrome coronavirus Result RT-PCR sequence severe disease specificity Surveillance syndrome tested the RBD the S protein Transmission virus was performed [DOI] 10.1186/s12985-017-0907-1 PMC 바로가기 [Article Type] Research
Genomic organization and recombination analysis of a porcine sapovirus identified from a piglet with diarrhea in ChinaResearch Published on 2017-03-162023-08-29 Journal: Virology Journal [Category] E형 간염, [키워드] genome organization Porcine sapovirus Recombination [DOI] 10.1186/s12985-017-0729-1 PMC 바로가기 [Article Type] Research
Human coronavirus 229E encodes a single ORF4 protein between the spike and the envelope genesResearch Published on 2006-12-282022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] 229E Accessory genes Amino acid amino acids Analysis analyzed CCU Cell culture Cold collected common conserved coronavirus coronavirus 229E determine ENCODE envelope gene FIVE Genes Genome genome organization HCoV-229E HCoV-NL63 homologue Human in vivo isolate Laboratory Netherland nucleotide ORF ORF3 protein ORF4b PEDV Protein Proteins prototype virus related Result sequence unit [DOI] 10.1186/1743-422X-3-106 PMC 바로가기 [Article Type] Research