Achieving global mortality reduction targets and universal health coverage: The impact of COVID-19Collection Review Published on 2021-06-242022-10-29 Journal: PLoS Medicine [Category] COVID-19, MERS, [키워드] COVID-19 COVID-19 pandemic global mortality Health implication reduction target [DOI] 10.1371/journal.pmed.1003675 PMC 바로가기 [Article Type] Collection Review
Risk factors, symptom reporting, healthcare-seeking behaviour and adherence to public health guidance: protocol for Virus Watch, a prospective community cohort studyPublic Health Published on 2021-06-232022-10-28 Journal: BMJ Open [Category] COVID-19, Fulltext, MERS, [키워드] Acute respiratory infection Analysis Antibody testing approach approval approved Blood caused Cohort cohort study Community coronavirus COVID-19 dissemination effective England Epidemiology Ethics ethics committee Evidence Factors global mortality Government Health Research Authority impacted incidence individuals methodology nasal swab National Health Service NHS pandemic participant PCR assay PCR testing preliminary finding profile protocol public health Public Health England recruit reducing SARS-CoV-2 serology Symptom Symptoms Transmission virus working through [DOI] 10.1136/bmjopen-2020-048042 PMC 바로가기 [Article Type] Public Health
Piece of the puzzle: Remdesivir disassembles the multimeric SARS-CoV-2 RNA-dependent RNA polymerase complex퍼즐 조각: Remdesivir는 다량체 SARS-CoV-2 RNA 의존성 RNA 중합효소 복합체를 분해합니다Article Published on 2021-06-012022-09-11 Journal: Cell biochemistry and biophysics [Category] SARS, 치료제, [키워드] Accelerated molecular dynamics simulation adenosine ATP binding complex computational simulations contribute Detachment disrupt domain domains finding flexible followed by global mortality higher affinity hosts Human mechanism molecular molecular dynamics Molecular dynamics simulation non-structural proteins Nsp7 NSP8 nucleotide PALM Perturbation piece RdRP Remdesivir Replication replicative reported RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-like coronavirus significantly Spread structure-based design subunit the SARS-CoV-2 underlie Viral RNA virus [DOI] 10.1007/s12013-021-00977-y PMC 바로가기 [Article Type] Article
Clinical characteristics of and outcomes for patients with COVID-19 and comorbid lung diseases primarily hospitalized in a conventional pulmonology unit: A retrospective study기존 폐병동에 주로 입원한 코로나19 및 동반이환 폐질환 환자의 임상적 특징과 결과: 후향적 연구Article Published on 2021-05-012022-09-11 Journal: Respiratory medicine and research [Category] 진단, 치료제, [키워드] age Asthma Characteristics chronic lung disease chronic lung diseases chronic obstructive chronic obstructive pulmonary disease CLD clinical Clinical characteristics Cohort confirmed case COPD coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients determine enrolled France global mortality Hospitalization Hospitalized ICU Infection intensive care intensive care unit lack Lung disease male management median age obstructive pulmonary disease outcome Patient patients patients died patients with COVID-19 Predictive pulmonary disease Pulmonology radiological representing respiratory respiratory diseases retrospective Retrospective study risk risk factor risk of COVID-19 SARS-CoV-2 severity significantly higher single-center study Symptoms tendency the median total mortality transferred university [DOI] 10.1016/j.resmer.2020.100801 PMC 바로가기 [Article Type] Article
Successful Management of COVID-19 Infection in 2 Early Post-Liver Transplant Recipients간 이식 후 조기 수혜자 2명의 성공적인 COVID-19 감염 관리Case Reports Published on 2021-05-012022-09-11 Journal: Transplantation proceedings [Category] SARS, 진단, 치료제, [키워드] administration affected Clinical course clinical feature Clinical features Comorbidities convalescent plasma coronavirus disease Coronavirus disease 2019 Corticosteroids Course COVID-19 COVID-19 infection COVID-19 patients COVID-19 pneumonia Critical current described description dose reduction Future global mortality help hospital Hospitalization Hydroxychloroquine Immunosuppression include increased risk Infection life liver liver transplant Liver transplantation low-dose management Methylprednisolone monoclonal antibodies morbidity morbidity and mortality mortality rate MOST organ Organ transplant organ transplantation organ transplants Patient patients patients with comorbidities patients with COVID-19 Preliminary data Prognosis recipient recipients Remdesivir Research Respiratory care Severe COVID-19 pneumonia suggested table Tocilizumab Transplant treated Treatment treatment of COVID-19 Two patient two patients vaccination vulnerability [DOI] 10.1016/j.transproceed.2021.03.010 PMC 바로가기 [Article Type] Case Reports
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactionsArticle Published on 2021-04-292022-10-31 Journal: Cell [Category] COVID-19, MERS, SARS, [키워드] Abstract anti-SARS-CoV-2 Antiviral antiviral activity antiviral immunity antiviral response approach ChIRP-MS Comparative analysis complexes connection CRISPR CRISPR screen CRISPR Screens defined demonstrated Factors functional global mortality highlight highlighting Host host protein host-pathogen interactions identify Immunity Infection integration Interaction majority Mitochondria organelle pandemic pathway physical platform PROTECT Protein protein interaction protein interactions rhinovirus RNA RNA virus RNA-binding proteins RNA-protein complex SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA Seven specificity the SARS-CoV-2 Therapeutic benefit These data virus virus-induced cell death [DOI] 10.1016/j.cell.2021.03.012 PMC 바로가기 [Article Type] Article
COVID-19 lockdown may increase cardiovascular disease risk factorsCommentary Published on 2021-01-052022-10-31 Journal: The Egyptian Heart Journal [Category] COVID-19, [키워드] acute respiratory syndrome alcohol cardiovascular disease caused chronic disease Compliance coronavirus Coronavirus disease 2019 country COVID-19 COVID-19 pandemic CVDs detrimental disease Factor global mortality increase in increased risk lockdown morbidity and mortality mortality rate Non-communicable disease pandemic physical activity preventive measure risk factor risk of death SARS CoV-2 self-quarantine Tobacco virus WHO World Health Organization worldwide pandemic [DOI] 10.1186/s43044-020-00127-4 PMC 바로가기 [Article Type] Commentary
COVID-19 in people living with HIV: A multicenter case-series studyObservational Study Published on 2021-01-012022-10-05 Journal: International Journal of Infectious Diseases [Category] 임상, [키워드] Affect age analyzed Antiretroviral therapy Arterial hypertension ARV association Comorbidities conducted cough COVID-19 COVID-19 patients determinant Diabetes Mellitus Dyspnea Factor Fever global mortality HIV HIV infection HIV patient HIV-negative hospital Hospitalization ICU admission infected patients Infection lower mortality median median age men mortality rate multicenter outcome Patient patients patients with HIV PLHIV Prognostic factor prospective cohort Public Hospital SARS-CoV-2 severe disease severity severity of COVID-19 Symptom Treatment with COVID-19 with HIV [DOI] 10.1016/j.ijid.2020.10.060 PMC 바로가기 [Article Type] Observational Study
The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteinsSARS-CoV-2 스파이크 단백질은 포유류 ACE2 단백질에 대해 광범위한 친화성을 가지고 있습니다.Research Article Published on 2020-12-212022-08-13 Journal: PLoS Biology [Category] Biology and Life Sciences, COVID-19, Fulltext, SARS, 조류인플루엔자, [키워드] absence ACE2 ACE2 protein ACE2 proteins ACE2 receptor ACE2 receptors addition aligned Amino acid amino acid residue amino acid residues amino acids angiotensin bat bat ACE2 bats bioinformatics cattle Cell changed China circulating Combination coronavirus coronavirus disease Coronavirus disease 2019 coronaviruses SARS-CoV COVID-19 Divergence examined global mortality glycoprotein Host host tropism Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human populations humans indicate infect Infection intermediate host investigated Live virus livestock mammalian Mutagenesis pandemic potential risk Protein Proteins RaTG13 receptor binding site receptors reservoirs SARS Coronavirus SARS coronavirus 2 SARS-CoV SARS-CoV-2 SARS-CoV-2 receptor sequence sequence similarity spike spike glycoprotein Spike protein the Spike thought tropism of SARS-CoV-2 Viral viral entry virus virus spread viruses wildlife zoonotic zoonotic transmission [DOI] 10.1371/journal.pbio.3001016 PMC 바로가기 [Article Type] Research Article
The transcriptomic profiling of SARS-CoV-2 compared to SARS, MERS, EBOV, and H1N1SARS, MERS, EBOV 및 H1N1과 비교한 SARS-CoV-2의 전사체 프로파일링Comparative Study Published on 2020-12-102022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 신종인플루엔자, 유전자 메커니즘, [키워드] Analysis anti-SARS-CoV-2 Arthritis association cellular claimed Comparative analysis COVID-19 Cytokines demonstrated determine FGF1 FIVE FOXO1 gene signature Genes Genetic global mortality GO term GO terms H1N1 heparin hepatitis B highly pathogenic host antiviral responses IL-6 IL-8 immune regulation Infection Inflammatory responses Influenza influenza A inhibitor Interaction involved life malaria MERS MERS-CoV miRNA modulation molecular NRCAM other respiratory virus Other respiratory viruses pandemic pathway potential therapy PPI protein-protein interaction provide RAGE respiratory respiratory viruses rheumatoid arthritis SAA2 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SERPINB1 Signaling significantly target the SARS-CoV-2 therapeutic Transcriptome transcriptomic understanding unique Viral viral infection viral infections virus viruses [DOI] 10.1371/journal.pone.0243270 PMC 바로가기 [Article Type] Comparative Study