Low BALF CD4 T cells count is associated with extubation failure and mortality in critically ill covid-19 pneumonia낮은 BALF CD4 T 세포 수는 중환자의 covid-19 폐렴에서 발관 실패 및 사망률과 관련이 있습니다Article Published on 2022-12-012022-09-11 Journal: Annals of Medicine [Category] 바이오마커, 진단, [키워드] affected alveolar alveolar macrophage analysed average BALF BALF CD4 T-cells count baseline Biomarker bivariate analysis Bronchoalveolar lavage fluid caspase caspase-3 cause CD4 CD4 T cell CD4 T-cell Characteristics clinical Clinical characteristics conducted COVID-19 COVID-19 patients COVID-19 pneumonia COVID-19 pneumonia patient COVID-19 pneumonia patients Critically ill critically ill COVID-19 patients Critically ill COVID-19 pneumonia D-dimer D-dimer level eight enrolled extubation failure. groups help IL-17 IL-6 immunopathology IMPROVE Indonesia intubation Invasive mechanical ventilation Laboratory lung Macrophage material Mortality no significant difference no significant differences outcome Patient performed Pneumonia profile Referral reported right lung severe pneumonia severity significant differences significantly survived T-cells Tertiary Tregs understanding was performed were measured [DOI] 10.1080/07853890.2022.2095012 PMC 바로가기 [Article Type] Article
Association of trace element status in COVID-19 patients with disease severityResearch article Published on 2022-12-012022-10-05 Journal: Journal of trace elements in medicine and biology [Category] COVID19(2023년), SARS, 변종, [키워드] Anti-inflammatory antioxidant clinical condition clinical symptom conditions coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 severity Critical Cu death died disease severity evaluated Fe four group groups I immune response immune system Infection Mg Mild symptom new SARS-CoV-2 no difference Patient reduce risk SARS-COV-2 infection Se Serum level severity severity of symptoms shown significant difference the patient Trace element trace elements Zn [DOI] 10.1016/j.jtemb.2022.127055 [Article Type] Research article
Efficacy of heterologous boosting against SARS-CoV-2 using a recombinant interferon-armed fusion protein vaccine (V-01): a randomized, double-blind and placebo-controlled phase III trial재조합 인터페론 무장 융합 단백질 백신(V-01)을 사용한 SARS-CoV-2에 대한 이종 부스팅의 효능: 무작위, 이중 맹검 및 위약 대조 3상 시험Clinical Trial Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] adverse event antibody assigned booster clinical trial common adverse event conducted COVID-19 vaccine COVID-19 vaccines dose double-blind dramatic increase Efficacy elicit eligible fatigue Fever fusion protein groups headache healthy Heterologous heterologous boosting Humoral immunity Identifier Immunity inactivated Inactivated vaccine Inactivated Vaccines Inc injection injection site intention-to-treat principle Malaysia Mild-to-moderate Neutralizing Neutralizing antibodies occurred Older omicron Omicron variant over Pain participant Participants Placebo placebo-controlled primary endpoint Randomized Randomly receive regimen robust Safe SARS-CoV-2 SARS-COV-2 infection second dose Serious Adverse Events subunit Subunit vaccine Subunit vaccine. Surveillance symptomatic SARS-CoV-2 infection the epidemic titre Trial Trial registration V-01 Vaccine vaccine efficacy variant virus-neutralizing antibodies was measured were assessed [DOI] 10.1080/22221751.2022.2088406 PMC 바로가기 [Article Type] Clinical Trial
Short-term exposure of the mayfly larvae (Cloeon dipterum, Ephemeroptera: Baetidae) to SARS-CoV-2-derived peptides and other emerging pollutants: A new threat for the aquatic environmentsArticle Published on 2022-11-252022-11-15 Journal: The Science of the total environment [Category] SARS, 바이오마커, [키워드] acetylcholinesterase addition ambient aquatic environment aquatic environments Biomarker Biomarkers Cloeon Combination concentrations coronavirus dismutase DPPH ecosystem Effect evaluate evidenced Freshwater ecosystems groups hospital Impact Insects Mortality New coronavirus nitrite Non-target organisms novel novel coronavirus. organism Organisms PCA peptide peptides principal component analysis raised reduced response risk SARS-CoV-2 scavenging significantly lower similarity Spread Stress Topic Treatment viral peptide [DOI] 10.1016/j.scitotenv.2022.157813 PMC 바로가기
Anxiety and depression in the post-pandemic era: concerns about viral mutation and re-outbreakArticle Published on 2022-11-032022-11-16 Journal: BMC Psychiatry [Category] SARS, 변종, [키워드] Anxiety changes in China city clinically Complete conducted convenience sampling coronavirus COVID-19 critically ill patients Depression depression. difference East effective Factor female GAD-7 groups Health healthy help illness IMPROVE infected patient infected patients likelihood logistic regression model males mental health no significant difference outbreak pandemic Patient Perception PHQ-9 Population Psychological psychological reaction public health system question questionnaire Questionnaires reduced reported required risk factor severity significant level Support the patient variant viral mutation [DOI] 10.1186/s12888-022-04307-1 PMC 바로가기
Modelling optimal vaccination strategies against COVID-19 in a context of Gamma variant predominance in BrazilArticle Published on 2022-11-022022-11-16 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, [키워드] accompanied age AZD1222 Brazil circulating variant Coverage COVID-19 death deaths dose driven by Effectiveness Epidemic estimates evaluate evaluated Evidence Gamma group groups Guidance health system immunization immunization strategy implementation increase in inefficient initial International interval Local modelling Older age outcome populations reached reducing required subsequent Support vaccination Vaccination strategy Vaccine vaccine availability Vaccines. variant variants of concern VoC [DOI] 10.1016/j.vaccine.2022.09.082 PMC 바로가기
Efficacy of antiseptic mouthrinses against SARS-CoV-2: A prospective randomized placebo-controlled pilot studyArticle Published on 2022-11-012022-11-15 Journal: American journal of otolaryngology [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Adult patients Affect analyzed baseline chlorhexidine clinical collected COVID-19 detectable Disinfection effective Effectiveness groups Hospitalized hydrogen peroxide individual initial mouth negativity oral oral cavity Oral diseases Oral medicine Oral rinses Patient pilot study Placebo placebo-controlled Povidone‑iodine Public public health Randomized recruited reduced reducing Replication Research Saliva. SARS-CoV-2 SARS-CoV-2 viral load swab specimens the placebo group viral copy number were measured [DOI] 10.1016/j.amjoto.2022.103549 PMC 바로가기
Prevalence of peripheral neuropathy and myopathy in patients post-COVID-19 infectionArticle Published on 2022-11-012022-11-16 Journal: International journal of rheumatic diseases [Category] SARS, 치료기술, [키워드] acute respiratory syndrome addition affecting All participant asymptomatic patient both group caused clinical examination Clinical signs Complete complications control group controls COVID-19 COVID-19 infection Department Electrophysiology Epidemic evaluate feature Gender groups healthy volunteer history Hospitalization Infection involved laboratory measure life-threatening long-lasting multiple organs Myopathy nervous system Patient patients performed Peripheral Neuropathy post-COVID-19 patient Prevalence problem recent respiratory symptom risk factor Risk factors Risk factors. SARS-CoV-2 serum creatine phosphokinase significant difference symptomatic without symptom [DOI] 10.1111/1756-185X.14409 PMC 바로가기
Distinct Immune Phenotypes and Cytokine Profiles in Children with Differing Severity of COVID-19Article Published on 2022-11-012022-11-15 Journal: The Pediatric Infectious Disease Journal [Category] SARS, 진단, 치료기술, [키워드] Absolute lymphocyte count activated acute phase acute respiratory syndrome Anti-inflammatory Antibody Response CD3 CD4 CD8 Cell children children with COVID-19 Clinical outcome clinical presentation coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine profile decrease dependent on disease severity distress effector memory exhibited groups help HLADR IL-1ra IL-1β immune mechanism Immune phenotype Immune profile increase in Infection Inflammatory Laboratory parameters Mild MIS-C no difference not significantly different Patient pediatric profile prospective cohort study RANTES SARS-CoV-2 IgG SARS-CoV2 sera severe disease severity syndrome T cell T cells tumor necrosis factor-α was performed with COVID-19 [DOI] 10.1097/INF.0000000000003669 PMC 바로가기
[Vaccination against coronavirus disease 2019 (COVID-19)]Article Published on 2022-11-012022-11-15 Journal: Zeitschrift Fur Gerontologie Und Geriatrie [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome adenoviral vector vaccine Adults age antibodies, neutralizing approval booster vaccination Clinical efficacy Concentration coronavirus coronavirus disease Course declined English Europe groups heterogeneous Hospitalization immunogenicity immunogenicity, vaccine increase Infection mRNA vaccines National neutralizing antibody New Older omicron original virus strain Patient recommendation recommendations reduced risk Risk factors SARS-CoV‑2 SARS-CoV‑2 variants severe disease tested Trial Vaccination recommendations. Vaccinations Vaccine vaccine dose Vaccines variant viral evolution virus variant virus variants [DOI] 10.1007/s00391-022-02102-x PMC 바로가기